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Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade

This paper aims to update the molecular status of porcine circovirus 2 (PCV2) in Malaysia. Firstly, the molecular detection rate of PCV2 in farm and sampled pig population were reported to be 83.78% (31/37 farms) and 83.54% (66/79 pigs) positive for PCV2, respectively. PCV2 was detected across all a...

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Main Authors: Tan, Chew Yee, Thanawongnuwech, Roongroje, Arshad, Siti Suri, Hassan, Latiffah, Wai, Michelle Cheng Fong, Ooi, Peck Toung
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2022
Online Access:http://psasir.upm.edu.my/id/eprint/101621/
https://www.mdpi.com/2076-2615/12/14/1849
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spelling my.upm.eprints.1016212023-08-11T08:40:17Z http://psasir.upm.edu.my/id/eprint/101621/ Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade Tan, Chew Yee Thanawongnuwech, Roongroje Arshad, Siti Suri Hassan, Latiffah Wai, Michelle Cheng Fong Ooi, Peck Toung This paper aims to update the molecular status of porcine circovirus 2 (PCV2) in Malaysia. Firstly, the molecular detection rate of PCV2 in farm and sampled pig population were reported to be 83.78% (31/37 farms) and 83.54% (66/79 pigs) positive for PCV2, respectively. PCV2 was detected across all age groups, from fetuses, porkers to sows. Co-detection of PCV2 and PCV3 antigens was also reported at a rate of 28.77% (21/73). Secondly, PCV2 antigen was also detected in Malaysian abattoir lung samples: 18 out of 19 (94.74%) samples originating from clinically healthy finishers were tested positive. Further, this is the first study to confirm the circulation of PCV2 in the wild boar population roaming Peninsular Malaysia, where 28 out of 28 (100%) wild boar lung samples were found positive. One decade earlier, only genotype PCV2b was reported in Malaysia. This most recent update revealed that genotypes PCV2a, PCV2b and PCV2d were present, with PCV2d being the predominant circulating genotype. PCV2 cap gene nucleotide sequences in this study were found to be under negative selection pressure, with an estimated substitution rate of 1.102 × 10−3 substitutions/site/year (ssy). Multidisciplinary Digital Publishing Institute 2022-07-21 Article PeerReviewed Tan, Chew Yee and Thanawongnuwech, Roongroje and Arshad, Siti Suri and Hassan, Latiffah and Wai, Michelle Cheng Fong and Ooi, Peck Toung (2022) Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade. Animals, 12 (14). art. no. 1849. pp. 1-21. ISSN 2076-2615 https://www.mdpi.com/2076-2615/12/14/1849 10.3390/ani12141849
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description This paper aims to update the molecular status of porcine circovirus 2 (PCV2) in Malaysia. Firstly, the molecular detection rate of PCV2 in farm and sampled pig population were reported to be 83.78% (31/37 farms) and 83.54% (66/79 pigs) positive for PCV2, respectively. PCV2 was detected across all age groups, from fetuses, porkers to sows. Co-detection of PCV2 and PCV3 antigens was also reported at a rate of 28.77% (21/73). Secondly, PCV2 antigen was also detected in Malaysian abattoir lung samples: 18 out of 19 (94.74%) samples originating from clinically healthy finishers were tested positive. Further, this is the first study to confirm the circulation of PCV2 in the wild boar population roaming Peninsular Malaysia, where 28 out of 28 (100%) wild boar lung samples were found positive. One decade earlier, only genotype PCV2b was reported in Malaysia. This most recent update revealed that genotypes PCV2a, PCV2b and PCV2d were present, with PCV2d being the predominant circulating genotype. PCV2 cap gene nucleotide sequences in this study were found to be under negative selection pressure, with an estimated substitution rate of 1.102 × 10−3 substitutions/site/year (ssy).
format Article
author Tan, Chew Yee
Thanawongnuwech, Roongroje
Arshad, Siti Suri
Hassan, Latiffah
Wai, Michelle Cheng Fong
Ooi, Peck Toung
spellingShingle Tan, Chew Yee
Thanawongnuwech, Roongroje
Arshad, Siti Suri
Hassan, Latiffah
Wai, Michelle Cheng Fong
Ooi, Peck Toung
Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade
author_facet Tan, Chew Yee
Thanawongnuwech, Roongroje
Arshad, Siti Suri
Hassan, Latiffah
Wai, Michelle Cheng Fong
Ooi, Peck Toung
author_sort Tan, Chew Yee
title Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade
title_short Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade
title_full Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade
title_fullStr Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade
title_full_unstemmed Genotype shift of Malaysian porcine circovirus 2 (PCV2) from PCV2b to PCV2d within a decade
title_sort genotype shift of malaysian porcine circovirus 2 (pcv2) from pcv2b to pcv2d within a decade
publisher Multidisciplinary Digital Publishing Institute
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/101621/
https://www.mdpi.com/2076-2615/12/14/1849
_version_ 1775624496921706496
score 13.211869

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