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Endolysins against Streptococci as an antibiotic alternative

Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis. Endolysins have been extensively research...

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Main Authors: Wong, Kuan Yee, Megat Mazhar Khair, Megat Hamzah, Song, Adelene Ai Lian, Masarudin, Mas Jaffri, Chong, Chou Min, Lian, Lionel Aun In, Yee, Michelle Mun Teo
Format: Article
Published: Frontiers Research Foundation 2022
Online Access:http://psasir.upm.edu.my/id/eprint/101248/
https://www.frontiersin.org/articles/10.3389/fmicb.2022.935145/full
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spelling my.upm.eprints.1012482023-06-19T08:16:08Z http://psasir.upm.edu.my/id/eprint/101248/ Endolysins against Streptococci as an antibiotic alternative Wong, Kuan Yee Megat Mazhar Khair, Megat Hamzah Song, Adelene Ai Lian Masarudin, Mas Jaffri Chong, Chou Min Lian, Lionel Aun In Yee, Michelle Mun Teo Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis. Endolysins have been extensively researched in different fields, including medicine, food, and agricultural applications. While the target specificity of various endolysins varies greatly between species, this current review focuses specifically on streptococcal endolysins. Streptococcus spp. causes numerous infections, from the common strep throat to much more serious life-threatening infections such as pneumonia and meningitis. It is reported as a major crisis in various industries, causing systemic infections associated with high mortality and morbidity, as well as economic losses, especially in the agricultural industry. This review highlights the types of catalytic and cell wall-binding domains found in streptococcal endolysins and gives a comprehensive account of the lytic ability of both native and engineered streptococcal endolysins studied thus far, as well as its potential application across different industries. Finally, it gives an overview of the advantages and limitations of these enzyme-based antibiotics, which has caused the term enzybiotics to be conferred to it. Frontiers Research Foundation 2022-08-02 Article PeerReviewed Wong, Kuan Yee and Megat Mazhar Khair, Megat Hamzah and Song, Adelene Ai Lian and Masarudin, Mas Jaffri and Chong, Chou Min and Lian, Lionel Aun In and Yee, Michelle Mun Teo (2022) Endolysins against Streptococci as an antibiotic alternative. Frontiers in Microbiology, 13. pp. 1-14. ISSN 1664-302X https://www.frontiersin.org/articles/10.3389/fmicb.2022.935145/full 10.3389/fmicb.2022.935145
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis. Endolysins have been extensively researched in different fields, including medicine, food, and agricultural applications. While the target specificity of various endolysins varies greatly between species, this current review focuses specifically on streptococcal endolysins. Streptococcus spp. causes numerous infections, from the common strep throat to much more serious life-threatening infections such as pneumonia and meningitis. It is reported as a major crisis in various industries, causing systemic infections associated with high mortality and morbidity, as well as economic losses, especially in the agricultural industry. This review highlights the types of catalytic and cell wall-binding domains found in streptococcal endolysins and gives a comprehensive account of the lytic ability of both native and engineered streptococcal endolysins studied thus far, as well as its potential application across different industries. Finally, it gives an overview of the advantages and limitations of these enzyme-based antibiotics, which has caused the term enzybiotics to be conferred to it.
format Article
author Wong, Kuan Yee
Megat Mazhar Khair, Megat Hamzah
Song, Adelene Ai Lian
Masarudin, Mas Jaffri
Chong, Chou Min
Lian, Lionel Aun In
Yee, Michelle Mun Teo
spellingShingle Wong, Kuan Yee
Megat Mazhar Khair, Megat Hamzah
Song, Adelene Ai Lian
Masarudin, Mas Jaffri
Chong, Chou Min
Lian, Lionel Aun In
Yee, Michelle Mun Teo
Endolysins against Streptococci as an antibiotic alternative
author_facet Wong, Kuan Yee
Megat Mazhar Khair, Megat Hamzah
Song, Adelene Ai Lian
Masarudin, Mas Jaffri
Chong, Chou Min
Lian, Lionel Aun In
Yee, Michelle Mun Teo
author_sort Wong, Kuan Yee
title Endolysins against Streptococci as an antibiotic alternative
title_short Endolysins against Streptococci as an antibiotic alternative
title_full Endolysins against Streptococci as an antibiotic alternative
title_fullStr Endolysins against Streptococci as an antibiotic alternative
title_full_unstemmed Endolysins against Streptococci as an antibiotic alternative
title_sort endolysins against streptococci as an antibiotic alternative
publisher Frontiers Research Foundation
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/101248/
https://www.frontiersin.org/articles/10.3389/fmicb.2022.935145/full
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score 13.211869

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