Staff View: Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia

Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia

Hydroxychloroquine (HCQ) is the first-line systemic treatment for cutaneous lupus erythematosus (CLE). Whole blood HCQ concentration (WBHCQ) was found to correlate with CLE severity among Caucasians. However, studies on Asians are scarce. We aim to explore the relationship of WBHCQ with CLE disease...

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Main Authors:	Peh, D., Wan Ahmad Kammal, W. S. L., Beh, P. J., Yong, A. C. H., Tan, W. C., Lim, A. L., Thevarajah, S., Stanslas, J., How, Kang Nien
Format:	Article
Published:	Wiley-Blackwell Publishing 2022
Online Access:	http://psasir.upm.edu.my/id/eprint/100818/ https://onlinelibrary.wiley.com/doi/abs/10.1111/1346-8138.16292
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spelling	my.upm.eprints.1008182023-08-17T07:33:19Z http://psasir.upm.edu.my/id/eprint/100818/ Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia Peh, D. Wan Ahmad Kammal, W. S. L. Beh, P. J. Yong, A. C. H. Tan, W. C. Lim, A. L. Thevarajah, S. Stanslas, J. How, Kang Nien Hydroxychloroquine (HCQ) is the first-line systemic treatment for cutaneous lupus erythematosus (CLE). Whole blood HCQ concentration (WBHCQ) was found to correlate with CLE severity among Caucasians. However, studies on Asians are scarce. We aim to explore the relationship of WBHCQ with CLE disease activity among multi-racial Malaysians and the factors associated with WBHCQ. A cross-sectional study targeting patients with CLE was conducted from 1 June till 30 November 2019. Disease activity was assessed using Cutaneous Lupus Erythematosus Disease Area and Severity Index – Activity Score (CLASI-AS). Blood was analyzed for WBHCQ concentration using a high-performance liquid chromatography technique. Statistical analysis was done using R studio version 1.2.1335. A total of 88 subjects (male : female, 4.5:1) with a median age of 41 years old were recruited. The median duration CLE was 5 years. The majority had acute cutaneous lupus (n = 45, 51.1%). The median WBHCQ was 946.8 ng/mL. Indians were found to have the highest WBHCQ (median ± interquartile range [IQR], 1515.4 ± 1494.8 ng/mL). Males had a lower WBHCQ (median ± IQR, 733.5 ± 573.8 ng/mL) than females (995.5 ± 925.1 ng/mL). However, no statistically significant association between race and sex with WBHCQ was demonstrable (p = 0.247, p = 0.066). No correlation was demonstrated between WBHCQ and CLASI-AS (r = −0.02, p = 0.851). A positive correlation was found between HCQ dosage (ideal bodyweight) and WBHCQ (r = 0.24, p = 0.027). No other factors were found associated with WBHCQ. Indians and females were observed to have higher WBCHQ; however, no significant correlation was identified. Further study is required to confirm the finding. Wiley-Blackwell Publishing 2022-01-24 Article PeerReviewed Peh, D. and Wan Ahmad Kammal, W. S. L. and Beh, P. J. and Yong, A. C. H. and Tan, W. C. and Lim, A. L. and Thevarajah, S. and Stanslas, J. and How, Kang Nien (2022) Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia. The Journal of Dermatology, 49 (5). pp. 545-549. ISSN 1346-8138 https://onlinelibrary.wiley.com/doi/abs/10.1111/1346-8138.16292 10.1111/1346-8138.16292
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
description	Hydroxychloroquine (HCQ) is the first-line systemic treatment for cutaneous lupus erythematosus (CLE). Whole blood HCQ concentration (WBHCQ) was found to correlate with CLE severity among Caucasians. However, studies on Asians are scarce. We aim to explore the relationship of WBHCQ with CLE disease activity among multi-racial Malaysians and the factors associated with WBHCQ. A cross-sectional study targeting patients with CLE was conducted from 1 June till 30 November 2019. Disease activity was assessed using Cutaneous Lupus Erythematosus Disease Area and Severity Index – Activity Score (CLASI-AS). Blood was analyzed for WBHCQ concentration using a high-performance liquid chromatography technique. Statistical analysis was done using R studio version 1.2.1335. A total of 88 subjects (male : female, 4.5:1) with a median age of 41 years old were recruited. The median duration CLE was 5 years. The majority had acute cutaneous lupus (n = 45, 51.1%). The median WBHCQ was 946.8 ng/mL. Indians were found to have the highest WBHCQ (median ± interquartile range [IQR], 1515.4 ± 1494.8 ng/mL). Males had a lower WBHCQ (median ± IQR, 733.5 ± 573.8 ng/mL) than females (995.5 ± 925.1 ng/mL). However, no statistically significant association between race and sex with WBHCQ was demonstrable (p = 0.247, p = 0.066). No correlation was demonstrated between WBHCQ and CLASI-AS (r = −0.02, p = 0.851). A positive correlation was found between HCQ dosage (ideal bodyweight) and WBHCQ (r = 0.24, p = 0.027). No other factors were found associated with WBHCQ. Indians and females were observed to have higher WBCHQ; however, no significant correlation was identified. Further study is required to confirm the finding.
format	Article
author	Peh, D. Wan Ahmad Kammal, W. S. L. Beh, P. J. Yong, A. C. H. Tan, W. C. Lim, A. L. Thevarajah, S. Stanslas, J. How, Kang Nien
spellingShingle	Peh, D. Wan Ahmad Kammal, W. S. L. Beh, P. J. Yong, A. C. H. Tan, W. C. Lim, A. L. Thevarajah, S. Stanslas, J. How, Kang Nien Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia
author_facet	Peh, D. Wan Ahmad Kammal, W. S. L. Beh, P. J. Yong, A. C. H. Tan, W. C. Lim, A. L. Thevarajah, S. Stanslas, J. How, Kang Nien
author_sort	Peh, D.
title	Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia
title_short	Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia
title_full	Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia
title_fullStr	Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia
title_full_unstemmed	Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia
title_sort	correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in malaysia
publisher	Wiley-Blackwell Publishing
publishDate	2022
url	http://psasir.upm.edu.my/id/eprint/100818/ https://onlinelibrary.wiley.com/doi/abs/10.1111/1346-8138.16292
_version_	1775624480574406656
score	13.211869

Correlation of whole blood hydroxychloroquine concentration with cutaneous lupus erythematosus and factors associated with it: first multicenter, cross-sectional analysis in Malaysia

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