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Childhood allergy susceptibility: the role of the immune system development in the in-utero period

Expression of allergic diseases in very early childhood indicates that early life events play a significant role in childhood allergy development. The developmental origins of allergy hypothesis suggest events initiated in the in-utero period derived from the interaction between maternal, placental,...

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Main Authors: Mohamad Zainal, Nurul Hayati, Mohd Nor, Nurul Huda, Saat, Azmah, Clifton, Vicki L.
Format: Article
Published: Elsevier 2022
Online Access:http://psasir.upm.edu.my/id/eprint/100689/
https://www.sciencedirect.com/science/article/pii/S0198885922000349#:~:text=These%20studies%20suggest%20a%20combination,in%20association%20with%20fetal%20growth.
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spelling my.upm.eprints.1006892023-09-11T08:26:58Z http://psasir.upm.edu.my/id/eprint/100689/ Childhood allergy susceptibility: the role of the immune system development in the in-utero period Mohamad Zainal, Nurul Hayati Mohd Nor, Nurul Huda Saat, Azmah Clifton, Vicki L. Expression of allergic diseases in very early childhood indicates that early life events play a significant role in childhood allergy development. The developmental origins of allergy hypothesis suggest events initiated in the in-utero period derived from the interaction between maternal, placental, and fetal factors may contribute to childhood allergy susceptibility. Environmental impacts on placental function and fetal programming are imperative in defining illness risk during pregnancy. Fetal programming, a process by which an injury delivered during a critical period of development, causes immediate adaptive responses with long-term consequences on an organism’s structure or function. During pregnancy, the maternal immune response is skewed towards Th2-related humoral responses, hence increasing the susceptibility of childhood allergy development. Maternal atopic phenotype markedly increases the probability of her offspring developing an allergic predisposition. Combination of in utero events – which include maternal asthma or infection, and exposures to maternal allergy which changes the placental function – can alter placental cytokine expression and could predispose offspring to an allergic phenotype. All these events may affect embryology and fetal immune system development. Interestingly, the mechanism and role of the in-utero events on the developmental origins of allergy are not clearly understood; this will be addressed in this review. Elsevier 2022-05 Article PeerReviewed Mohamad Zainal, Nurul Hayati and Mohd Nor, Nurul Huda and Saat, Azmah and Clifton, Vicki L. (2022) Childhood allergy susceptibility: the role of the immune system development in the in-utero period. Human Immunology, 83 (5). pp. 1-10. ISSN 0198-8859 https://www.sciencedirect.com/science/article/pii/S0198885922000349#:~:text=These%20studies%20suggest%20a%20combination,in%20association%20with%20fetal%20growth. 10.1016/j.humimm.2022.02.002
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Expression of allergic diseases in very early childhood indicates that early life events play a significant role in childhood allergy development. The developmental origins of allergy hypothesis suggest events initiated in the in-utero period derived from the interaction between maternal, placental, and fetal factors may contribute to childhood allergy susceptibility. Environmental impacts on placental function and fetal programming are imperative in defining illness risk during pregnancy. Fetal programming, a process by which an injury delivered during a critical period of development, causes immediate adaptive responses with long-term consequences on an organism’s structure or function. During pregnancy, the maternal immune response is skewed towards Th2-related humoral responses, hence increasing the susceptibility of childhood allergy development. Maternal atopic phenotype markedly increases the probability of her offspring developing an allergic predisposition. Combination of in utero events – which include maternal asthma or infection, and exposures to maternal allergy which changes the placental function – can alter placental cytokine expression and could predispose offspring to an allergic phenotype. All these events may affect embryology and fetal immune system development. Interestingly, the mechanism and role of the in-utero events on the developmental origins of allergy are not clearly understood; this will be addressed in this review.
format Article
author Mohamad Zainal, Nurul Hayati
Mohd Nor, Nurul Huda
Saat, Azmah
Clifton, Vicki L.
spellingShingle Mohamad Zainal, Nurul Hayati
Mohd Nor, Nurul Huda
Saat, Azmah
Clifton, Vicki L.
Childhood allergy susceptibility: the role of the immune system development in the in-utero period
author_facet Mohamad Zainal, Nurul Hayati
Mohd Nor, Nurul Huda
Saat, Azmah
Clifton, Vicki L.
author_sort Mohamad Zainal, Nurul Hayati
title Childhood allergy susceptibility: the role of the immune system development in the in-utero period
title_short Childhood allergy susceptibility: the role of the immune system development in the in-utero period
title_full Childhood allergy susceptibility: the role of the immune system development in the in-utero period
title_fullStr Childhood allergy susceptibility: the role of the immune system development in the in-utero period
title_full_unstemmed Childhood allergy susceptibility: the role of the immune system development in the in-utero period
title_sort childhood allergy susceptibility: the role of the immune system development in the in-utero period
publisher Elsevier
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/100689/
https://www.sciencedirect.com/science/article/pii/S0198885922000349#:~:text=These%20studies%20suggest%20a%20combination,in%20association%20with%20fetal%20growth.
_version_ 1778163728552820736
score 13.211869

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