Staff View: Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method

Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method

In toxicological analysis, the analytical validation method is important to assess the exact risk of contaminants of emerging concern in the environment. Syringe filters are mainly used to remove impurities from sample solutions. However, the loss of analyte to the syringe filter could be considerab...

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Main Authors:	Razak, Muhammad Raznisyafiq, Aris, Ahmad Zaharin, Sukatis, Fahren Fazzer, Mohd Zaki, Muhammad Rozaimi, Zainuddin, Azim Haziq, Mohamad Haron, Didi Erwandi, Md Yusoff, Fatimah, Yusof, Zetty Norhana Balia
Format:	Article
Published:	Wiley 2022
Online Access:	http://psasir.upm.edu.my/id/eprint/100601/ https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jssc.202200282
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spelling	my.upm.eprints.1006012023-10-09T18:42:45Z http://psasir.upm.edu.my/id/eprint/100601/ Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method Razak, Muhammad Raznisyafiq Aris, Ahmad Zaharin Sukatis, Fahren Fazzer Mohd Zaki, Muhammad Rozaimi Zainuddin, Azim Haziq Mohamad Haron, Didi Erwandi Md Yusoff, Fatimah Yusof, Zetty Norhana Balia In toxicological analysis, the analytical validation method is important to assess the exact risk of contaminants of emerging concern in the environment. Syringe filters are mainly used to remove impurities from sample solutions. However, the loss of analyte to the syringe filter could be considerable, causing an underestimate of the analyte concentrations. The current study develops and validates simultaneous liquid chromatography-mass spectrometry analysis using a direct filtration method to detect four groups of contaminants of emerging concern. The adsorption of the analyte onto three different matrices and six types of syringe filters is reported. The lowest adsorption of analytes was observed in methanol (16.72%), followed by deionized water (48.19%) and filtered surface lake water (48.94%). Irrespective of the type of the matrices, the lowest average adsorption by the syringe filter was observed in the 0.45 μm polypropylene membrane (15.15%), followed by the 0.20 μm polypropylene membrane (16.10%), the 0.20 μm regenerated cellulose (16.15%), the 0.20 μm polytetrafluoroethylene membrane (47.38%), the 0.45 μm nylon membrane (64.87%) and the 0.20 μm nylon membrane (71.30%). In conclusion, the recommended syringe filter membranes for contaminants of emerging concern analysis are polypropylene membranes and regenerated cellulose, regardless of the matrix used. Wiley 2022-11-07 Article PeerReviewed Razak, Muhammad Raznisyafiq and Aris, Ahmad Zaharin and Sukatis, Fahren Fazzer and Mohd Zaki, Muhammad Rozaimi and Zainuddin, Azim Haziq and Mohamad Haron, Didi Erwandi and Md Yusoff, Fatimah and Yusof, Zetty Norhana Balia (2022) Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method. Journal of Separation Science, 46 (1). art. no. 2200282. ISSN 1615-9306; ESSN: 1615-9314 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jssc.202200282 10.1002/jssc.202200282
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
description	In toxicological analysis, the analytical validation method is important to assess the exact risk of contaminants of emerging concern in the environment. Syringe filters are mainly used to remove impurities from sample solutions. However, the loss of analyte to the syringe filter could be considerable, causing an underestimate of the analyte concentrations. The current study develops and validates simultaneous liquid chromatography-mass spectrometry analysis using a direct filtration method to detect four groups of contaminants of emerging concern. The adsorption of the analyte onto three different matrices and six types of syringe filters is reported. The lowest adsorption of analytes was observed in methanol (16.72%), followed by deionized water (48.19%) and filtered surface lake water (48.94%). Irrespective of the type of the matrices, the lowest average adsorption by the syringe filter was observed in the 0.45 μm polypropylene membrane (15.15%), followed by the 0.20 μm polypropylene membrane (16.10%), the 0.20 μm regenerated cellulose (16.15%), the 0.20 μm polytetrafluoroethylene membrane (47.38%), the 0.45 μm nylon membrane (64.87%) and the 0.20 μm nylon membrane (71.30%). In conclusion, the recommended syringe filter membranes for contaminants of emerging concern analysis are polypropylene membranes and regenerated cellulose, regardless of the matrix used.
format	Article
author	Razak, Muhammad Raznisyafiq Aris, Ahmad Zaharin Sukatis, Fahren Fazzer Mohd Zaki, Muhammad Rozaimi Zainuddin, Azim Haziq Mohamad Haron, Didi Erwandi Md Yusoff, Fatimah Yusof, Zetty Norhana Balia
spellingShingle	Razak, Muhammad Raznisyafiq Aris, Ahmad Zaharin Sukatis, Fahren Fazzer Mohd Zaki, Muhammad Rozaimi Zainuddin, Azim Haziq Mohamad Haron, Didi Erwandi Md Yusoff, Fatimah Yusof, Zetty Norhana Balia Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
author_facet	Razak, Muhammad Raznisyafiq Aris, Ahmad Zaharin Sukatis, Fahren Fazzer Mohd Zaki, Muhammad Rozaimi Zainuddin, Azim Haziq Mohamad Haron, Didi Erwandi Md Yusoff, Fatimah Yusof, Zetty Norhana Balia
author_sort	Razak, Muhammad Raznisyafiq
title	Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_short	Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_full	Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_fullStr	Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_full_unstemmed	Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_sort	development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
publisher	Wiley
publishDate	2022
url	http://psasir.upm.edu.my/id/eprint/100601/ https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jssc.202200282
_version_	1781706665001746432
score	13.211869

Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method

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