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Bioactive peptides and its alternative processes: a review

Bioactive peptides are molecules of paramount importance with significant health benefits. These bioactive peptides extracted from various food sources demonstrated significant bioactivity and potency, including angiotensin-converting enzyme inhibitors, antioxidants, opioids, and antimicrobials. How...

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Main Authors: Abd-Talib, Norfahana, Anak Yaji, Emmy Liza, Abd Wahab, Nur Suraya, Razali, Nadia, Yong, Kelly Tau Len, Roslan, Jumardi, Saari, Nazamid, Pa’ee, Khairul Faizal
Format: Article
Published: Springer 2022
Online Access:http://psasir.upm.edu.my/id/eprint/100533/
https://link.springer.com/article/10.1007/s12257-021-0160-8
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spelling my.upm.eprints.1005332023-11-21T09:03:29Z http://psasir.upm.edu.my/id/eprint/100533/ Bioactive peptides and its alternative processes: a review Abd-Talib, Norfahana Anak Yaji, Emmy Liza Abd Wahab, Nur Suraya Razali, Nadia Yong, Kelly Tau Len Roslan, Jumardi Saari, Nazamid Pa’ee, Khairul Faizal Bioactive peptides are molecules of paramount importance with significant health benefits. These bioactive peptides extracted from various food sources demonstrated significant bioactivity and potency, including angiotensin-converting enzyme inhibitors, antioxidants, opioids, and antimicrobials. However, various challenges hindered the industrial-scale production of peptides, such as the sensory performance of peptides due to bitterness, low peptides bioavailability and yield, minimal human tests, unconfirmed molecular mechanisms, and the sustainability of the resources for mass production. The emerging alternative processes such as high hydrostatic pressure, microwave, ultrasound, sub- and supercritical fluids are selectively beneficial, albeit time-consuming and expensive. The diversity of the properties of bioactive peptides complicates the design of the appropriate purification steps, particularly for novel peptides. The integrative process by coupling the production and purification of bioactive peptides to a single integrative system can be a way forward for bioactive peptides production with high purity, potency, and cost-effectiveness. Thus, the review provides a comprehensive insight into the current status, trends, and challenges of bioactive peptide production through conventional and emerging processes. Meanwhile, the potential technological leap through integrative processes is also featured as the sustainability of the process must be assured. Springer 2022-06-15 Article PeerReviewed Abd-Talib, Norfahana and Anak Yaji, Emmy Liza and Abd Wahab, Nur Suraya and Razali, Nadia and Yong, Kelly Tau Len and Roslan, Jumardi and Saari, Nazamid and Pa’ee, Khairul Faizal (2022) Bioactive peptides and its alternative processes: a review. Biotechnology and Bioprocess Engineering, 27. 306 - 335. ISSN 1226-8372; ESSN: 1976-3816 https://link.springer.com/article/10.1007/s12257-021-0160-8 10.1007/s12257-021-0160-8
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Bioactive peptides are molecules of paramount importance with significant health benefits. These bioactive peptides extracted from various food sources demonstrated significant bioactivity and potency, including angiotensin-converting enzyme inhibitors, antioxidants, opioids, and antimicrobials. However, various challenges hindered the industrial-scale production of peptides, such as the sensory performance of peptides due to bitterness, low peptides bioavailability and yield, minimal human tests, unconfirmed molecular mechanisms, and the sustainability of the resources for mass production. The emerging alternative processes such as high hydrostatic pressure, microwave, ultrasound, sub- and supercritical fluids are selectively beneficial, albeit time-consuming and expensive. The diversity of the properties of bioactive peptides complicates the design of the appropriate purification steps, particularly for novel peptides. The integrative process by coupling the production and purification of bioactive peptides to a single integrative system can be a way forward for bioactive peptides production with high purity, potency, and cost-effectiveness. Thus, the review provides a comprehensive insight into the current status, trends, and challenges of bioactive peptide production through conventional and emerging processes. Meanwhile, the potential technological leap through integrative processes is also featured as the sustainability of the process must be assured.
format Article
author Abd-Talib, Norfahana
Anak Yaji, Emmy Liza
Abd Wahab, Nur Suraya
Razali, Nadia
Yong, Kelly Tau Len
Roslan, Jumardi
Saari, Nazamid
Pa’ee, Khairul Faizal
spellingShingle Abd-Talib, Norfahana
Anak Yaji, Emmy Liza
Abd Wahab, Nur Suraya
Razali, Nadia
Yong, Kelly Tau Len
Roslan, Jumardi
Saari, Nazamid
Pa’ee, Khairul Faizal
Bioactive peptides and its alternative processes: a review
author_facet Abd-Talib, Norfahana
Anak Yaji, Emmy Liza
Abd Wahab, Nur Suraya
Razali, Nadia
Yong, Kelly Tau Len
Roslan, Jumardi
Saari, Nazamid
Pa’ee, Khairul Faizal
author_sort Abd-Talib, Norfahana
title Bioactive peptides and its alternative processes: a review
title_short Bioactive peptides and its alternative processes: a review
title_full Bioactive peptides and its alternative processes: a review
title_fullStr Bioactive peptides and its alternative processes: a review
title_full_unstemmed Bioactive peptides and its alternative processes: a review
title_sort bioactive peptides and its alternative processes: a review
publisher Springer
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/100533/
https://link.springer.com/article/10.1007/s12257-021-0160-8
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score 13.211869

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