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Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser

We report herein the design and synthesis of colloidally-stable S/Ag1.93S nanoparticles, their photothermal conversion properties and in vitro cytotoxicity toward A431 skin cancer cells under the excitation of a minimally-invasive 980 nm near-infrared (NIR) laser. Micron-sized S particles were first...

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Main Authors: Wei, Chuen Yoong, Chui, Fung Loke, Joon, Ching Juan, Yusoff, Khatijah, Mohtarrudin, Norhafizah, Tatsuma, Tetsu, Ying, Xu, Teck, Hock Lim
Format: Article
Published: Elsevier 2022
Online Access:http://psasir.upm.edu.my/id/eprint/100166/
https://www.sciencedirect.com/science/article/pii/S0141813022000782
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spelling my.upm.eprints.1001662024-07-11T04:25:42Z http://psasir.upm.edu.my/id/eprint/100166/ Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser Wei, Chuen Yoong Chui, Fung Loke Joon, Ching Juan Yusoff, Khatijah Mohtarrudin, Norhafizah Tatsuma, Tetsu Ying, Xu Teck, Hock Lim We report herein the design and synthesis of colloidally-stable S/Ag1.93S nanoparticles, their photothermal conversion properties and in vitro cytotoxicity toward A431 skin cancer cells under the excitation of a minimally-invasive 980 nm near-infrared (NIR) laser. Micron-sized S particles were first synthesized via acidifying Na2S2O3 using biocompatible sodium alginate as a surfactant. In the presence of AgNO3 and under rapid microwave-induced heating, alginate reduced AgNO3 to nascent Ag which reacted with molten S in situ forming S/Ag1.93S nanoparticles. The nanoparticles were characterized using a combination of X-ray diffraction, electron microscopies, elemental analysis, zeta-potential analysis and UV–VIS-NIR spectroscopy. The average particles size was controlled between 40 and 60 nm by fixing the mole ratio of Ag+:S2O32−. When excited by a 980 nm laser, S/Ag1.93S nanoparticles (~40 nm) produced with the least amount of AgNO3 exhibited a respectable photothermal conversion efficiency of circa 62% with the test aqueous solution heated to a hyperthermia-inducing 52 °C in 15 min. At 0.7 W/cm2, the viability of A431 skin cancer cells incubated with 7.0 ± 0.2 μg/mL of S/Ag1.93S nanoparticles reduced to 14 ± 0.6%, while an A431 cell control maintained an 80% cell viability. These results suggested that S/Ag1.93S nanoparticles may have good potential in reducing metastatic skin carcinoma. Elsevier 2022-03-15 Article PeerReviewed Wei, Chuen Yoong and Chui, Fung Loke and Joon, Ching Juan and Yusoff, Khatijah and Mohtarrudin, Norhafizah and Tatsuma, Tetsu and Ying, Xu and Teck, Hock Lim (2022) Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser. International Journal of Biological Macromolecules, 201. 516 - 527. ISSN 0141-8130 https://www.sciencedirect.com/science/article/pii/S0141813022000782 10.1016/j.ijbiomac.2022.01.062
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description We report herein the design and synthesis of colloidally-stable S/Ag1.93S nanoparticles, their photothermal conversion properties and in vitro cytotoxicity toward A431 skin cancer cells under the excitation of a minimally-invasive 980 nm near-infrared (NIR) laser. Micron-sized S particles were first synthesized via acidifying Na2S2O3 using biocompatible sodium alginate as a surfactant. In the presence of AgNO3 and under rapid microwave-induced heating, alginate reduced AgNO3 to nascent Ag which reacted with molten S in situ forming S/Ag1.93S nanoparticles. The nanoparticles were characterized using a combination of X-ray diffraction, electron microscopies, elemental analysis, zeta-potential analysis and UV–VIS-NIR spectroscopy. The average particles size was controlled between 40 and 60 nm by fixing the mole ratio of Ag+:S2O32−. When excited by a 980 nm laser, S/Ag1.93S nanoparticles (~40 nm) produced with the least amount of AgNO3 exhibited a respectable photothermal conversion efficiency of circa 62% with the test aqueous solution heated to a hyperthermia-inducing 52 °C in 15 min. At 0.7 W/cm2, the viability of A431 skin cancer cells incubated with 7.0 ± 0.2 μg/mL of S/Ag1.93S nanoparticles reduced to 14 ± 0.6%, while an A431 cell control maintained an 80% cell viability. These results suggested that S/Ag1.93S nanoparticles may have good potential in reducing metastatic skin carcinoma.
format Article
author Wei, Chuen Yoong
Chui, Fung Loke
Joon, Ching Juan
Yusoff, Khatijah
Mohtarrudin, Norhafizah
Tatsuma, Tetsu
Ying, Xu
Teck, Hock Lim
spellingShingle Wei, Chuen Yoong
Chui, Fung Loke
Joon, Ching Juan
Yusoff, Khatijah
Mohtarrudin, Norhafizah
Tatsuma, Tetsu
Ying, Xu
Teck, Hock Lim
Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser
author_facet Wei, Chuen Yoong
Chui, Fung Loke
Joon, Ching Juan
Yusoff, Khatijah
Mohtarrudin, Norhafizah
Tatsuma, Tetsu
Ying, Xu
Teck, Hock Lim
author_sort Wei, Chuen Yoong
title Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser
title_short Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser
title_full Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser
title_fullStr Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser
title_full_unstemmed Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser
title_sort alginate-enabled green synthesis of s/ag1.93s nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a nir laser
publisher Elsevier
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/100166/
https://www.sciencedirect.com/science/article/pii/S0141813022000782
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score 13.22586

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