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A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies

Cancer remains one of the key causes of mortality globally, in spite of the availability of advanced detection and treatment strategies. Conventional cancer therapies have non-selectivity to the target cells. Secondly, conventional cancer therapies are proved to cause various side effects during the...

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Main Authors: Goh, Kar Shin, Ng, Zhang Jin, Halim, Murni, Oslan, Siti Nurbaya, Oslan, Siti Nur Hazwani, Tan, Joo Shun
Format: Article
Published: Springer 2022
Online Access:http://psasir.upm.edu.my/id/eprint/100102/
https://link.springer.com/article/10.1007/s10989-022-10386-1
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spelling my.upm.eprints.1001022024-08-01T04:00:20Z http://psasir.upm.edu.my/id/eprint/100102/ A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies Goh, Kar Shin Ng, Zhang Jin Halim, Murni Oslan, Siti Nurbaya Oslan, Siti Nur Hazwani Tan, Joo Shun Cancer remains one of the key causes of mortality globally, in spite of the availability of advanced detection and treatment strategies. Conventional cancer therapies have non-selectivity to the target cells. Secondly, conventional cancer therapies are proved to cause various side effects during the treatment. Lastly, cancer cells are known to develop resistance to the currently available therapies. Therefore, there is a demand for a novel therapy for various types of cancer. Some of the bacteriocins have been reported to have an anti-cancer effect against various types of cancer cells. Bacteriocins are proteins synthesized by bacterial ribosomes. They have shown high selectivity toward the cancer cells and low cytotoxicity toward normal cells. This makes them a promising anticancer candidate to replace or combine with conventional therapeutic agents. In this review, the latest studies on the selectivity of bacteriocins against cancer cells and their anticancer activities in preclinical and clinical studies will be discussed. Springer 2022-03-12 Article PeerReviewed Goh, Kar Shin and Ng, Zhang Jin and Halim, Murni and Oslan, Siti Nurbaya and Oslan, Siti Nur Hazwani and Tan, Joo Shun (2022) A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies. International Journal of Peptide Research and Therapeutics, 28 (75). ISSN 1573-3149; ESSN: 1573-3904 https://link.springer.com/article/10.1007/s10989-022-10386-1 10.1007/s10989-022-10386-1
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Cancer remains one of the key causes of mortality globally, in spite of the availability of advanced detection and treatment strategies. Conventional cancer therapies have non-selectivity to the target cells. Secondly, conventional cancer therapies are proved to cause various side effects during the treatment. Lastly, cancer cells are known to develop resistance to the currently available therapies. Therefore, there is a demand for a novel therapy for various types of cancer. Some of the bacteriocins have been reported to have an anti-cancer effect against various types of cancer cells. Bacteriocins are proteins synthesized by bacterial ribosomes. They have shown high selectivity toward the cancer cells and low cytotoxicity toward normal cells. This makes them a promising anticancer candidate to replace or combine with conventional therapeutic agents. In this review, the latest studies on the selectivity of bacteriocins against cancer cells and their anticancer activities in preclinical and clinical studies will be discussed.
format Article
author Goh, Kar Shin
Ng, Zhang Jin
Halim, Murni
Oslan, Siti Nurbaya
Oslan, Siti Nur Hazwani
Tan, Joo Shun
spellingShingle Goh, Kar Shin
Ng, Zhang Jin
Halim, Murni
Oslan, Siti Nurbaya
Oslan, Siti Nur Hazwani
Tan, Joo Shun
A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies
author_facet Goh, Kar Shin
Ng, Zhang Jin
Halim, Murni
Oslan, Siti Nurbaya
Oslan, Siti Nur Hazwani
Tan, Joo Shun
author_sort Goh, Kar Shin
title A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies
title_short A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies
title_full A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies
title_fullStr A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies
title_full_unstemmed A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies
title_sort comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies
publisher Springer
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/100102/
https://link.springer.com/article/10.1007/s10989-022-10386-1
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score 13.211869

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