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The edema inducing activity of phospholipase A2 enzymes

The edema inducing activity of phospholipase A2 (PLA2) enzymes from snake venoms and porcine pancreas was investigated using mouse paw as experimental model. All ten PLA2 enzymes exhibited potent edema inducing activity. PLA2, however, is generally not the major edema inducing component of snake ven...

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Main Authors: Tan, N.-H., Saifuddin, M.N., Young, W.-Y.
Format: Article
Language:en_US
Published: 2017
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spelling my.uniten.dspace-60502018-02-21T03:49:23Z The edema inducing activity of phospholipase A2 enzymes Tan, N.-H. Saifuddin, M.N. Young, W.-Y. The edema inducing activity of phospholipase A2 (PLA2) enzymes from snake venoms and porcine pancreas was investigated using mouse paw as experimental model. All ten PLA2 enzymes exhibited potent edema inducing activity. PLA2, however, is generally not the major edema inducing component of snake venom. Chemical modification studies indicated that enzymatic activity of PLA2 was required for its edema inducing activity. All PLA2 enzymes examined displayed a rapid onset edema which was suppressed by pretreatment of the mice with antihistamine. Dexamethasone pretreatment also inhihited edemas elicited by some PLA2 enzymes. 2017-12-08T08:12:26Z 2017-12-08T08:12:26Z 1991 Article https://pure.uniten.edu.my/en/publications/the-edema-inducing-activity-of-phospholipase-asub2sub-enzymes en_US The edema inducing activity of phospholipase A2 enzymes. Biochemistry International, 23(1), 175-181
institution Universiti Tenaga Nasional
building UNITEN Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tenaga Nasional
content_source UNITEN Institutional Repository
url_provider http://dspace.uniten.edu.my/
language en_US
description The edema inducing activity of phospholipase A2 (PLA2) enzymes from snake venoms and porcine pancreas was investigated using mouse paw as experimental model. All ten PLA2 enzymes exhibited potent edema inducing activity. PLA2, however, is generally not the major edema inducing component of snake venom. Chemical modification studies indicated that enzymatic activity of PLA2 was required for its edema inducing activity. All PLA2 enzymes examined displayed a rapid onset edema which was suppressed by pretreatment of the mice with antihistamine. Dexamethasone pretreatment also inhihited edemas elicited by some PLA2 enzymes.
format Article
author Tan, N.-H.
Saifuddin, M.N.
Young, W.-Y.
spellingShingle Tan, N.-H.
Saifuddin, M.N.
Young, W.-Y.
The edema inducing activity of phospholipase A2 enzymes
author_facet Tan, N.-H.
Saifuddin, M.N.
Young, W.-Y.
author_sort Tan, N.-H.
title The edema inducing activity of phospholipase A2 enzymes
title_short The edema inducing activity of phospholipase A2 enzymes
title_full The edema inducing activity of phospholipase A2 enzymes
title_fullStr The edema inducing activity of phospholipase A2 enzymes
title_full_unstemmed The edema inducing activity of phospholipase A2 enzymes
title_sort edema inducing activity of phospholipase a2 enzymes
publishDate 2017
_version_ 1644493829423759360
score 13.211869

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