Staff View: FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT

FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT

Currently, immunotherapy is seen to be the most effective cancer treatment. This is especially true while treating chronic lymphocytic leukemia (CLL), a slow-growing B-lymphocyte neoplasm that gradually compromises the immune system. Mathematical modeling is acknowledged as a key technique for analy...

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Main Authors:	Jan R., Razak N.N.A., Alyobi S., Khan Z., Hosseini K., Park C., Salahshour S., Paokanta S.
Other Authors:	57205596279
Format:	Article
Published:	World Scientific 2025
Subjects:	Chemotherapy Diseases Dynamics Atanganum-baleanu derivative B lymphocytes Cancer research Chaotic behaviour Chaotic phenomenon Chronic lymphocytic leukemias Fractional calculus Fractional dynamics Lymphocytic leukemia Stability analyze Numerical methods
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id	my.uniten.dspace-37111
record_format	dspace
spelling	my.uniten.dspace-371112025-03-03T15:47:36Z FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT Jan R. Razak N.N.A. Alyobi S. Khan Z. Hosseini K. Park C. Salahshour S. Paokanta S. 57205596279 37059587300 57891336000 57997905800 36903183800 15051122700 23028598900 57215716650 Chemotherapy Diseases Dynamics Atanganum-baleanu derivative B lymphocytes Cancer research Chaotic behaviour Chaotic phenomenon Chronic lymphocytic leukemias Fractional calculus Fractional dynamics Lymphocytic leukemia Stability analyze Numerical methods Currently, immunotherapy is seen to be the most effective cancer treatment. This is especially true while treating chronic lymphocytic leukemia (CLL), a slow-growing B-lymphocyte neoplasm that gradually compromises the immune system. Mathematical modeling is acknowledged as a key technique for analyzing theoretical and practical challenges in this field of cancer research and others. We were inspired to develop a mathematical model because of its dearth in investigations of chemotherapy-induced immunotherapy for CLL. This study effort formulates the dynamics of lymphocytic leukemia utilizing fractional calculus to conceptualize the complex processes of this viral illness. The basic idea of fractional calculus has been shown using the Atangana-Baleanu framework. For the suggested model's chaotic and dynamic behavior, a new numerical approach is described. We inspect the stability and convergence of the suggested numerical technique in our work. The fluctuation of various system input elements has demonstrated the oscillatory and chaotic behavior of the system. Moreover, we have demonstrated how the suggested mechanism of lymphocytic leukemia infection is affected by fractional order. Through numerical simulations, the most important input parameters are emphasized, and the policymakers are given control intervention suggestions. ? 2024 World Scientific. All rights reserved. Final 2025-03-03T07:47:36Z 2025-03-03T07:47:36Z 2024 Article 10.1142/S0218348X24400127 2-s2.0-85182568820 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182568820&doi=10.1142%2fS0218348X24400127&partnerID=40&md5=aa327246d97a20b176779b4d25dc5f0c https://irepository.uniten.edu.my/handle/123456789/37111 32 2 2440012 World Scientific Scopus
institution	Universiti Tenaga Nasional
building	UNITEN Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Tenaga Nasional
content_source	UNITEN Institutional Repository
url_provider	http://dspace.uniten.edu.my/
topic	Chemotherapy Diseases Dynamics Atanganum-baleanu derivative B lymphocytes Cancer research Chaotic behaviour Chaotic phenomenon Chronic lymphocytic leukemias Fractional calculus Fractional dynamics Lymphocytic leukemia Stability analyze Numerical methods
spellingShingle	Chemotherapy Diseases Dynamics Atanganum-baleanu derivative B lymphocytes Cancer research Chaotic behaviour Chaotic phenomenon Chronic lymphocytic leukemias Fractional calculus Fractional dynamics Lymphocytic leukemia Stability analyze Numerical methods Jan R. Razak N.N.A. Alyobi S. Khan Z. Hosseini K. Park C. Salahshour S. Paokanta S. FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT
description	Currently, immunotherapy is seen to be the most effective cancer treatment. This is especially true while treating chronic lymphocytic leukemia (CLL), a slow-growing B-lymphocyte neoplasm that gradually compromises the immune system. Mathematical modeling is acknowledged as a key technique for analyzing theoretical and practical challenges in this field of cancer research and others. We were inspired to develop a mathematical model because of its dearth in investigations of chemotherapy-induced immunotherapy for CLL. This study effort formulates the dynamics of lymphocytic leukemia utilizing fractional calculus to conceptualize the complex processes of this viral illness. The basic idea of fractional calculus has been shown using the Atangana-Baleanu framework. For the suggested model's chaotic and dynamic behavior, a new numerical approach is described. We inspect the stability and convergence of the suggested numerical technique in our work. The fluctuation of various system input elements has demonstrated the oscillatory and chaotic behavior of the system. Moreover, we have demonstrated how the suggested mechanism of lymphocytic leukemia infection is affected by fractional order. Through numerical simulations, the most important input parameters are emphasized, and the policymakers are given control intervention suggestions. ? 2024 World Scientific. All rights reserved.
author2	57205596279
author_facet	57205596279 Jan R. Razak N.N.A. Alyobi S. Khan Z. Hosseini K. Park C. Salahshour S. Paokanta S.
format	Article
author	Jan R. Razak N.N.A. Alyobi S. Khan Z. Hosseini K. Park C. Salahshour S. Paokanta S.
author_sort	Jan R.
title	FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT
title_short	FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT
title_full	FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT
title_fullStr	FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT
title_full_unstemmed	FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT
title_sort	fractional dynamics of chronic lymphocytic leukemia with the effect of chemoimmunotherapy treatment
publisher	World Scientific
publishDate	2025
_version_	1826077340837347328
score	13.244413

FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT

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