Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review
Abstract Hindered phenols find a wide variety of applications across many different industry sectors. Butylated hydroxytoluene (BHT) is a most commonly used antioxidant recognized as safe for use in foods containing fats, pharmaceuticals, petroleum products, rubber and oil industries. In the past tw...
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my.uniten.dspace-35062020-06-29T04:19:09Z Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review Yehye, W.A. Rahman, N.A. Ariffin, A. Abd Hamid, S.B. Alhadi, A.A. Kadir, F.A. Yaeghoobi, M. Abstract Hindered phenols find a wide variety of applications across many different industry sectors. Butylated hydroxytoluene (BHT) is a most commonly used antioxidant recognized as safe for use in foods containing fats, pharmaceuticals, petroleum products, rubber and oil industries. In the past two decades, there has been growing interest in finding novel antioxidants to meet the requirements of these industries. To accelerate the antioxidant discovery process, researchers have designed and synthesized a series of BHT derivatives targeting to improve its antioxidant properties to be having a wide range of antioxidant activities markedly enhanced radical scavenging ability and other physical properties. Accordingly, some structure-activity relationships and rational design strategies for antioxidants based on BHT structure have been suggested and applied in practice. We have identified 14 very sensitive parameters, which may play a major role on the antioxidant performance of BHT. In this review, we attempt to summarize the current knowledge on this topic, which is of significance in selecting and designing novel antioxidants using a well-known antioxidant BHT as a building-block molecule. Our strategy involved investigation on understanding the chemistry behind the antioxidant activities of BHT, whether through hydrogen or electron transfer mechanism to enable promising anti-oxidant candidates to be synthesized. © 2015 Elsevier Masson SAS. 2017-10-27T06:14:29Z 2017-10-27T06:14:29Z 2015 Article 10.1016/j.ejmech.2015.06.026 en European Journal of Medicinal Chemistry Volume 101, 7 July 2015, Article number 7953, Pages 295-312 |
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Abstract Hindered phenols find a wide variety of applications across many different industry sectors. Butylated hydroxytoluene (BHT) is a most commonly used antioxidant recognized as safe for use in foods containing fats, pharmaceuticals, petroleum products, rubber and oil industries. In the past two decades, there has been growing interest in finding novel antioxidants to meet the requirements of these industries. To accelerate the antioxidant discovery process, researchers have designed and synthesized a series of BHT derivatives targeting to improve its antioxidant properties to be having a wide range of antioxidant activities markedly enhanced radical scavenging ability and other physical properties. Accordingly, some structure-activity relationships and rational design strategies for antioxidants based on BHT structure have been suggested and applied in practice. We have identified 14 very sensitive parameters, which may play a major role on the antioxidant performance of BHT. In this review, we attempt to summarize the current knowledge on this topic, which is of significance in selecting and designing novel antioxidants using a well-known antioxidant BHT as a building-block molecule. Our strategy involved investigation on understanding the chemistry behind the antioxidant activities of BHT, whether through hydrogen or electron transfer mechanism to enable promising anti-oxidant candidates to be synthesized. © 2015 Elsevier Masson SAS. |
| format |
Article |
| author |
Yehye, W.A. Rahman, N.A. Ariffin, A. Abd Hamid, S.B. Alhadi, A.A. Kadir, F.A. Yaeghoobi, M. |
| spellingShingle |
Yehye, W.A. Rahman, N.A. Ariffin, A. Abd Hamid, S.B. Alhadi, A.A. Kadir, F.A. Yaeghoobi, M. Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review |
| author_facet |
Yehye, W.A. Rahman, N.A. Ariffin, A. Abd Hamid, S.B. Alhadi, A.A. Kadir, F.A. Yaeghoobi, M. |
| author_sort |
Yehye, W.A. |
| title |
Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review |
| title_short |
Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review |
| title_full |
Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review |
| title_fullStr |
Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review |
| title_full_unstemmed |
Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review |
| title_sort |
understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (bht): a review |
| publishDate |
2017 |
| _version_ |
1671342875846115328 |
| score |
13.223943 |