Release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system
Intercalation of an antihypertensive drug, captopril (CPL) into zinc�aluminum-layered (ZAL) double hydroxide carrier was successfully accomplished via co-precipitation method. The resulting material was investigated by powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimet...
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my.uniten.dspace-344102024-10-14T11:19:35Z Release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system Jadam M.L. Jubri Z. Sarijo S.H. 57193566449 35778292400 8609580900 Antihypertensive drug Captopril Controlled release Drug delivery system Zinc�aluminum-layered double hydroxide Aluminum compounds Controlled drug delivery Drug products Field emission microscopes Fourier transform infrared spectroscopy Nanocomposites Precipitation (chemical) Targeted drug delivery Thermogravimetric analysis Zinc Antihypertensive drugs Captopril Controlled release Coprecipitation method Drug-delivery systems Layered-double hydroxides Release behaviors Zinc aluminiums Zinc-aluminum Zinc�aluminum-layered double hydroxide Scanning electron microscopy Intercalation of an antihypertensive drug, captopril (CPL) into zinc�aluminum-layered (ZAL) double hydroxide carrier was successfully accomplished via co-precipitation method. The resulting material was investigated by powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric and differential thermogravimetric�(TGA/DTG) analysis, carbon, hydrogen, nitrogen, and sulfur (CHNS) analysis, field emission scanning electron microscopy, and accelerated surface area and porosity (ASAP) analysis. High loading percentage of CPL (61.6% [w/w]) in zinc�aluminum�captopril-layered double hydroxide (ZAC) with an interlayer spacing of 9.7 � suggested the successful intercalation of CPL into the ZAL interlayer. Release percentages of the drug into Na3PO4, Na2CO3, and NaCl solutions are 48%, 30%, and 24%, respectively. Pseudo-second order kinetic model with correlation coefficient, r2 > 0.9 best defined the release behavior of CPL from ZAC nanocomposite into the aqueous media. Cytotoxicity study reveals lower toxic nature of ZAC nanohybrid (IC50 > 200��g/mL) compared to pristine CPL drug (IC50 < 200��g/mL) when tested on HUVEC and 3T3 cells. For the work described in this research, the organic-inorganic hybrid nanocomposite, ZAC could have good application in slow releases formulation of the drug delivery system. � 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. Final 2024-10-14T03:19:35Z 2024-10-14T03:19:35Z 2023 Article 10.1007/s10934-022-01333-y 2-s2.0-85137438305 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137438305&doi=10.1007%2fs10934-022-01333-y&partnerID=40&md5=75938b3daa28293a31b8b1c28c71003e https://irepository.uniten.edu.my/handle/123456789/34410 30 1 223 233 Springer Scopus |
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Antihypertensive drug Captopril Controlled release Drug delivery system Zinc�aluminum-layered double hydroxide Aluminum compounds Controlled drug delivery Drug products Field emission microscopes Fourier transform infrared spectroscopy Nanocomposites Precipitation (chemical) Targeted drug delivery Thermogravimetric analysis Zinc Antihypertensive drugs Captopril Controlled release Coprecipitation method Drug-delivery systems Layered-double hydroxides Release behaviors Zinc aluminiums Zinc-aluminum Zinc�aluminum-layered double hydroxide Scanning electron microscopy |
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Antihypertensive drug Captopril Controlled release Drug delivery system Zinc�aluminum-layered double hydroxide Aluminum compounds Controlled drug delivery Drug products Field emission microscopes Fourier transform infrared spectroscopy Nanocomposites Precipitation (chemical) Targeted drug delivery Thermogravimetric analysis Zinc Antihypertensive drugs Captopril Controlled release Coprecipitation method Drug-delivery systems Layered-double hydroxides Release behaviors Zinc aluminiums Zinc-aluminum Zinc�aluminum-layered double hydroxide Scanning electron microscopy Jadam M.L. Jubri Z. Sarijo S.H. Release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system |
| description |
Intercalation of an antihypertensive drug, captopril (CPL) into zinc�aluminum-layered (ZAL) double hydroxide carrier was successfully accomplished via co-precipitation method. The resulting material was investigated by powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric and differential thermogravimetric�(TGA/DTG) analysis, carbon, hydrogen, nitrogen, and sulfur (CHNS) analysis, field emission scanning electron microscopy, and accelerated surface area and porosity (ASAP) analysis. High loading percentage of CPL (61.6% [w/w]) in zinc�aluminum�captopril-layered double hydroxide (ZAC) with an interlayer spacing of 9.7 � suggested the successful intercalation of CPL into the ZAL interlayer. Release percentages of the drug into Na3PO4, Na2CO3, and NaCl solutions are 48%, 30%, and 24%, respectively. Pseudo-second order kinetic model with correlation coefficient, r2 > 0.9 best defined the release behavior of CPL from ZAC nanocomposite into the aqueous media. Cytotoxicity study reveals lower toxic nature of ZAC nanohybrid (IC50 > 200��g/mL) compared to pristine CPL drug (IC50 < 200��g/mL) when tested on HUVEC and 3T3 cells. For the work described in this research, the organic-inorganic hybrid nanocomposite, ZAC could have good application in slow releases formulation of the drug delivery system. � 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| author2 |
57193566449 |
| author_facet |
57193566449 Jadam M.L. Jubri Z. Sarijo S.H. |
| format |
Article |
| author |
Jadam M.L. Jubri Z. Sarijo S.H. |
| author_sort |
Jadam M.L. |
| title |
Release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system |
| title_short |
Release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system |
| title_full |
Release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system |
| title_fullStr |
Release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system |
| title_full_unstemmed |
Release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system |
| title_sort |
release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system |
| publisher |
Springer |
| publishDate |
2024 |
| _version_ |
1814061178775666688 |
| score |
13.222552 |