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A Fractional Perspective on the Dynamics of HIV, Considering the Interaction of Viruses and Immune System with the Effect of Antiretroviral Therapy

HIV infection is a worldwide health threat, necessitating a multifaceted strategy that includes prevention, testing, treatment and care. Moreover, it is essential to address the structural and social factors that influence the spread of this viral infection. In this study, we utilize fractional calc...

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Main Authors: Tang T.-Q., Jan R., Ahmad H., Shah Z., Vrinceanu N., Racheriu M.
Other Authors: 57191995128
Format: Article
Published: Institute for Ionics 2024
Subjects:
Antiretroviral therapy
Dynamical behavior
Fractional-calculus
HIV dynamics
Immune system
Numerical scheme
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spelling my.uniten.dspace-339272024-10-14T11:17:27Z A Fractional Perspective on the Dynamics of HIV, Considering the Interaction of Viruses and Immune System with the Effect of Antiretroviral Therapy Tang T.-Q. Jan R. Ahmad H. Shah Z. Vrinceanu N. Racheriu M. 57191995128 57205596279 58525153300 57194441902 26434973300 57201688417 Antiretroviral therapy Dynamical behavior Fractional-calculus HIV dynamics Immune system Numerical scheme HIV infection is a worldwide health threat, necessitating a multifaceted strategy that includes prevention, testing, treatment and care. Moreover, it is essential to address the structural and social factors that influence the spread of this viral infection. In this study, we utilize fractional calculus to clarify the dynamics of HIV infection in vivo, specifically examining the interface amid the HIV and the immune system and taking into account the impact of antiretroviral therapy. We use important results from fractional theory to analyze our proposed model of HIV infection and developed a numerical scheme to depict the system�s dynamic behavior. By varying input factors, we were able to observe the system�s chaotic nature and track its trajectory, as well as examine the effect of viruses on T-cells. Our results reveal key factors affecting the system, and demonstrate the consequence of antiretroviral therapy on our proposed model of HIV. Moreover, we observe that the system�s strong non-linearity is responsible for the oscillation phenomena and identify the most sensitive parameters of the system. � 2023, The Author(s). Final 2024-10-14T03:17:27Z 2024-10-14T03:17:27Z 2023 Article 10.1007/s44198-023-00133-5 2-s2.0-85166922342 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85166922342&doi=10.1007%2fs44198-023-00133-5&partnerID=40&md5=3691327d9e73894545ff8c0077e9cad3 https://irepository.uniten.edu.my/handle/123456789/33927 30 4 1327 1344 All Open Access Hybrid Gold Open Access Institute for Ionics Scopus
institution Universiti Tenaga Nasional
building UNITEN Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tenaga Nasional
content_source UNITEN Institutional Repository
url_provider http://dspace.uniten.edu.my/
topic Antiretroviral therapy
Dynamical behavior
Fractional-calculus
HIV dynamics
Immune system
Numerical scheme
spellingShingle Antiretroviral therapy
Dynamical behavior
Fractional-calculus
HIV dynamics
Immune system
Numerical scheme
Tang T.-Q.
Jan R.
Ahmad H.
Shah Z.
Vrinceanu N.
Racheriu M.
A Fractional Perspective on the Dynamics of HIV, Considering the Interaction of Viruses and Immune System with the Effect of Antiretroviral Therapy
description HIV infection is a worldwide health threat, necessitating a multifaceted strategy that includes prevention, testing, treatment and care. Moreover, it is essential to address the structural and social factors that influence the spread of this viral infection. In this study, we utilize fractional calculus to clarify the dynamics of HIV infection in vivo, specifically examining the interface amid the HIV and the immune system and taking into account the impact of antiretroviral therapy. We use important results from fractional theory to analyze our proposed model of HIV infection and developed a numerical scheme to depict the system�s dynamic behavior. By varying input factors, we were able to observe the system�s chaotic nature and track its trajectory, as well as examine the effect of viruses on T-cells. Our results reveal key factors affecting the system, and demonstrate the consequence of antiretroviral therapy on our proposed model of HIV. Moreover, we observe that the system�s strong non-linearity is responsible for the oscillation phenomena and identify the most sensitive parameters of the system. � 2023, The Author(s).
author2 57191995128
author_facet 57191995128
Tang T.-Q.
Jan R.
Ahmad H.
Shah Z.
Vrinceanu N.
Racheriu M.
format Article
author Tang T.-Q.
Jan R.
Ahmad H.
Shah Z.
Vrinceanu N.
Racheriu M.
author_sort Tang T.-Q.
title A Fractional Perspective on the Dynamics of HIV, Considering the Interaction of Viruses and Immune System with the Effect of Antiretroviral Therapy
title_short A Fractional Perspective on the Dynamics of HIV, Considering the Interaction of Viruses and Immune System with the Effect of Antiretroviral Therapy
title_full A Fractional Perspective on the Dynamics of HIV, Considering the Interaction of Viruses and Immune System with the Effect of Antiretroviral Therapy
title_fullStr A Fractional Perspective on the Dynamics of HIV, Considering the Interaction of Viruses and Immune System with the Effect of Antiretroviral Therapy
title_full_unstemmed A Fractional Perspective on the Dynamics of HIV, Considering the Interaction of Viruses and Immune System with the Effect of Antiretroviral Therapy
title_sort fractional perspective on the dynamics of hiv, considering the interaction of viruses and immune system with the effect of antiretroviral therapy
publisher Institute for Ionics
publishDate 2024
_version_ 1814061032479391744
score 13.222552

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