Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation
Drug delivery; Fourier transform infrared spectroscopy; Molar ratio; Anion-exchange methods; Antibacterial drugs; Basal spacing; Double hydroxides; Drug formulations; Layered-double hydroxides; Molar ratio; Optimum concentration; Pattern analysis; Surface porosity; Antibiotics
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Trans Tech Publications Ltd
2023
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my.uniten.dspace-264702023-05-29T17:10:54Z Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation Monica L.J. Zaemah J. Siti Halimah S. 57193566449 57216965739 57361426200 Drug delivery; Fourier transform infrared spectroscopy; Molar ratio; Anion-exchange methods; Antibacterial drugs; Basal spacing; Double hydroxides; Drug formulations; Layered-double hydroxides; Molar ratio; Optimum concentration; Pattern analysis; Surface porosity; Antibiotics An antibacterial drug, ciprofloxacin (Cipro) was successfully encapsulated into Ca/Allayered double hydroxide (CLDH) with molar ratio Ca/Al = 3:1 (R3) by anion exchange method at optimum concentration of 0.2 M Cipro. The successful intercalation was confirmed by patterns analysis of powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), elemental analysis (CHNS) and accelerated surface area and porosity (ASAP) analysis. Basal spacing of CLDH synthesized in this study is 8.7 �. Due to the inclusion of Cipro into the layered CLDH, basal spacing expanded to 16.2 � in Ca/Al-Cipro-LDH (CCLDH) compare to in CLDH. The FTIR spectra of the hybrid nanocomposite show resemblance peaks of the layered double hydroxide (LDH) and Cipro, indicating the inclusion of the drug anion into the LDH interlamellae. The percentage loading of Cipro calculated from the data obtained from CHNS is 75.9% (w/w). This shows that Ca/Al-layered double hydroxide, CLDH has prospective application as the host for ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid), an antibacterial drug for a novel drug delivery formulation. � 2021 Trans Tech Publications Ltd, Switzerland. Final 2023-05-29T09:10:54Z 2023-05-29T09:10:54Z 2021 Conference Paper 10.4028/www.scientific.net/SSP.317.233 2-s2.0-85120521081 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120521081&doi=10.4028%2fwww.scientific.net%2fSSP.317.233&partnerID=40&md5=1eec14051dbc6e3c68512c86b3ebad56 https://irepository.uniten.edu.my/handle/123456789/26470 317 SSP 233 238 Trans Tech Publications Ltd Scopus |
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| description |
Drug delivery; Fourier transform infrared spectroscopy; Molar ratio; Anion-exchange methods; Antibacterial drugs; Basal spacing; Double hydroxides; Drug formulations; Layered-double hydroxides; Molar ratio; Optimum concentration; Pattern analysis; Surface porosity; Antibiotics |
| author2 |
57193566449 |
| author_facet |
57193566449 Monica L.J. Zaemah J. Siti Halimah S. |
| format |
Conference Paper |
| author |
Monica L.J. Zaemah J. Siti Halimah S. |
| spellingShingle |
Monica L.J. Zaemah J. Siti Halimah S. Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation |
| author_sort |
Monica L.J. |
| title |
Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation |
| title_short |
Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation |
| title_full |
Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation |
| title_fullStr |
Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation |
| title_full_unstemmed |
Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation |
| title_sort |
synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation |
| publisher |
Trans Tech Publications Ltd |
| publishDate |
2023 |
| _version_ |
1806428441578307584 |
| score |
13.211869 |