Development of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluation
Acrylic monomers; Biocompatibility; Biopolymers; Body fluids; Bone; Cell culture; Contact angle; Defects; Free radical polymerization; Free radicals; Graphene; Hydrogels; Hydroxyapatite; Nanocomposites; Scaffolds (biology); Structural optimization; Tissue regeneration; Bio-based composites; Biopolym...
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2023
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my.uniten.dspace-259302023-05-29T17:05:36Z Development of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluation Khan M.U.A. Razak S.I.A. Ansari M.N.M. Zulkifli R.M. Ahmad Zawawi N. Arshad M. 57195462142 57201381533 55489853600 36612692200 57221642834 57202472817 Acrylic monomers; Biocompatibility; Biopolymers; Body fluids; Bone; Cell culture; Contact angle; Defects; Free radical polymerization; Free radicals; Graphene; Hydrogels; Hydroxyapatite; Nanocomposites; Scaffolds (biology); Structural optimization; Tissue regeneration; Bio-based composites; Biopolymer; Bone defect; Bone graft; Bone substitutes; Bone tissue engineering; In-vitro; Nano-hydroxyapatite; Porous scaffold; Regenerative medicine; Biodegradation Several significant advancements in the field of bone regenerative medicine have been made in recent years. However, therapeutic options, such as bone grafts, have several drawbacks. There is a need to develop an adequate bone substitute. As a result, significant bone defects/injuries pose a severe challenge for orthopaedic and reconstructive bone tissue. We synthesized polymeric composite material from arabinoxylan (ARX), ?-glucan (BG), nano-hydroxyapatite (nHAp), graphene oxide (GO), acrylic acid (AAc) through free radical polymerization and porous scaffold fabricated using the freezedrying technique. These fabricated porous scaffolds were then coated with chitosan solution to enhance their biological activities. The complex structure of BG, nHAp, GO was studied through various characterization and biological assays. The structural, morphological, wetting and mechanical analyses were determined using FT-IR, XRD, XPS, SEM/EXD, water contact angle and UTM. The swelling (aqueous and PBS media) and degradation (PBS media) observed their behavior in contact with body fluid. The biological activities were conducted against mouse pre-osteoblast cell lines. The result found that BGH3 has desirable morphological, structural with optimum swelling, degradation, and mechanical behavior. It was also found to be cytocompatible against MC3T3-E1 cell lines. The obtained results confirmed that the fabricated polymeric scaffolds would be a potential bone substitute to regenerate defective bone with different loading bearing applications for bone tissue engineering. � 2021 by the authors. Licensee MDPI, Basel, Switzerland. Final 2023-05-29T09:05:36Z 2023-05-29T09:05:36Z 2021 Article 10.3390/polym13213611 2-s2.0-85118104949 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118104949&doi=10.3390%2fpolym13213611&partnerID=40&md5=ea63f0c6547f0b243a01deac8ee08c02 https://irepository.uniten.edu.my/handle/123456789/25930 13 21 3611 All Open Access, Gold, Green MDPI Scopus |
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| description |
Acrylic monomers; Biocompatibility; Biopolymers; Body fluids; Bone; Cell culture; Contact angle; Defects; Free radical polymerization; Free radicals; Graphene; Hydrogels; Hydroxyapatite; Nanocomposites; Scaffolds (biology); Structural optimization; Tissue regeneration; Bio-based composites; Biopolymer; Bone defect; Bone graft; Bone substitutes; Bone tissue engineering; In-vitro; Nano-hydroxyapatite; Porous scaffold; Regenerative medicine; Biodegradation |
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57195462142 |
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57195462142 Khan M.U.A. Razak S.I.A. Ansari M.N.M. Zulkifli R.M. Ahmad Zawawi N. Arshad M. |
| format |
Article |
| author |
Khan M.U.A. Razak S.I.A. Ansari M.N.M. Zulkifli R.M. Ahmad Zawawi N. Arshad M. |
| spellingShingle |
Khan M.U.A. Razak S.I.A. Ansari M.N.M. Zulkifli R.M. Ahmad Zawawi N. Arshad M. Development of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluation |
| author_sort |
Khan M.U.A. |
| title |
Development of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluation |
| title_short |
Development of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluation |
| title_full |
Development of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluation |
| title_fullStr |
Development of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluation |
| title_full_unstemmed |
Development of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluation |
| title_sort |
development of biodegradable bio-based composite for bone tissue engineering: synthesis, characterization and in vitro biocompatible evaluation |
| publisher |
MDPI |
| publishDate |
2023 |
| _version_ |
1806426590125490176 |
| score |
13.211869 |