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Synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc-aluminium layered double hydroxide [Sintesis dan pencirian nanohibrid ubat anti-hipertensi, captopril tersisip ke dalam zink-aluminium hidroksida berlapis ganda]

Captopril (CPL), an anti-hypertensive drug was intercalated into the interlayer spaces of zinc-aluminium layered double hydroxide (ZLDH) for the formation of zinc-aluminium-captopril (ZCPL) hybrid nanocomposite material by self-assembly method. The concentration of CPL used was 0.08 M with pH 7.5 in...

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Main Authors: Zaemah J., Sarijo S.H., Jadam M.L.A.
Other Authors: 57216965739
Format: Article
Published: Malaysian Society of Analytical Sciences 2023
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spelling my.uniten.dspace-246972023-05-29T15:25:58Z Synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc-aluminium layered double hydroxide [Sintesis dan pencirian nanohibrid ubat anti-hipertensi, captopril tersisip ke dalam zink-aluminium hidroksida berlapis ganda] Zaemah J. Sarijo S.H. Jadam M.L.A. 57216965739 8609580900 57193566449 Captopril (CPL), an anti-hypertensive drug was intercalated into the interlayer spaces of zinc-aluminium layered double hydroxide (ZLDH) for the formation of zinc-aluminium-captopril (ZCPL) hybrid nanocomposite material by self-assembly method. The concentration of CPL used was 0.08 M with pH 7.5 in a constant 3:1 molar ratio of zinc (Zn) to aluminium (Al) in the mother liquor. As a result of the successful intercalation of CPL, powder X-ray diffraction pattern (PXRD) shows the basal spacing increased from 8.90 � in ZLDH to 9.69 � in the ZCPL nanohybrid material. Fourier transform infrared (FTIR) spectroscopy study shows the intercalated compound of ZCPL resembled the spectra of ZLDH and CPL, thus indicating the presence of both functional groups in ZCPL spectra. CHNS analysis shows the ZCPL nanohybrid material contains 30.63% (w/w) of CPL which was calculated based on the percentage of carbon in the sample. It was also found that the BET surface area increased from 1.7 m2/g in ZLDH to 10.9 m2/g in ZCPL. The pore texture of the resulting material was also changed as the result of the intercalation and the expansion of the basal spacing during the formation of the layered intercalated ZCPL nanohybrid material. � 2019, Malaysian Society of Analytical Sciences. All rights reserved. Final 2023-05-29T07:25:58Z 2023-05-29T07:25:58Z 2019 Article 10.17576/mjas-2019-2302-10 2-s2.0-85085574809 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085574809&doi=10.17576%2fmjas-2019-2302-10&partnerID=40&md5=66eb19e955ac0a8b18ced5b01f3c104d https://irepository.uniten.edu.my/handle/123456789/24697 23 2 255 262 All Open Access, Bronze Malaysian Society of Analytical Sciences Scopus
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country Malaysia
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description Captopril (CPL), an anti-hypertensive drug was intercalated into the interlayer spaces of zinc-aluminium layered double hydroxide (ZLDH) for the formation of zinc-aluminium-captopril (ZCPL) hybrid nanocomposite material by self-assembly method. The concentration of CPL used was 0.08 M with pH 7.5 in a constant 3:1 molar ratio of zinc (Zn) to aluminium (Al) in the mother liquor. As a result of the successful intercalation of CPL, powder X-ray diffraction pattern (PXRD) shows the basal spacing increased from 8.90 � in ZLDH to 9.69 � in the ZCPL nanohybrid material. Fourier transform infrared (FTIR) spectroscopy study shows the intercalated compound of ZCPL resembled the spectra of ZLDH and CPL, thus indicating the presence of both functional groups in ZCPL spectra. CHNS analysis shows the ZCPL nanohybrid material contains 30.63% (w/w) of CPL which was calculated based on the percentage of carbon in the sample. It was also found that the BET surface area increased from 1.7 m2/g in ZLDH to 10.9 m2/g in ZCPL. The pore texture of the resulting material was also changed as the result of the intercalation and the expansion of the basal spacing during the formation of the layered intercalated ZCPL nanohybrid material. � 2019, Malaysian Society of Analytical Sciences. All rights reserved.
author2 57216965739
author_facet 57216965739
Zaemah J.
Sarijo S.H.
Jadam M.L.A.
format Article
author Zaemah J.
Sarijo S.H.
Jadam M.L.A.
spellingShingle Zaemah J.
Sarijo S.H.
Jadam M.L.A.
Synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc-aluminium layered double hydroxide [Sintesis dan pencirian nanohibrid ubat anti-hipertensi, captopril tersisip ke dalam zink-aluminium hidroksida berlapis ganda]
author_sort Zaemah J.
title Synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc-aluminium layered double hydroxide [Sintesis dan pencirian nanohibrid ubat anti-hipertensi, captopril tersisip ke dalam zink-aluminium hidroksida berlapis ganda]
title_short Synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc-aluminium layered double hydroxide [Sintesis dan pencirian nanohibrid ubat anti-hipertensi, captopril tersisip ke dalam zink-aluminium hidroksida berlapis ganda]
title_full Synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc-aluminium layered double hydroxide [Sintesis dan pencirian nanohibrid ubat anti-hipertensi, captopril tersisip ke dalam zink-aluminium hidroksida berlapis ganda]
title_fullStr Synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc-aluminium layered double hydroxide [Sintesis dan pencirian nanohibrid ubat anti-hipertensi, captopril tersisip ke dalam zink-aluminium hidroksida berlapis ganda]
title_full_unstemmed Synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc-aluminium layered double hydroxide [Sintesis dan pencirian nanohibrid ubat anti-hipertensi, captopril tersisip ke dalam zink-aluminium hidroksida berlapis ganda]
title_sort synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc-aluminium layered double hydroxide [sintesis dan pencirian nanohibrid ubat anti-hipertensi, captopril tersisip ke dalam zink-aluminium hidroksida berlapis ganda]
publisher Malaysian Society of Analytical Sciences
publishDate 2023
_version_ 1806423354189545472
score 13.211869

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