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Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance

Calcium phosphate cement (CPC) for injectable bone cement application has been developed in this study. The CPC was produced using a novel wet chemical precipitation method derived hydroxyapatite (HA) powder. The calcium and phosphorus precursors used to synthesize HA powder were calcium hydroxide,...

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Main Authors: Hablee, S., Samsudin, N., Sopyan, I., Mel, M., Salleh, H.M., Rahman, M.M., Hashim, Y.Z.H.-Y., Raus, R.A.
Format: Article
Language:English
Published: 2020
Online Access:http://dspace.uniten.edu.my/jspui/handle/123456789/13122
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spelling my.uniten.dspace-131222020-09-21T02:45:22Z Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance Hablee, S. Samsudin, N. Sopyan, I. Mel, M. Salleh, H.M. Rahman, M.M. Hashim, Y.Z.H.-Y. Raus, R.A. Calcium phosphate cement (CPC) for injectable bone cement application has been developed in this study. The CPC was produced using a novel wet chemical precipitation method derived hydroxyapatite (HA) powder. The calcium and phosphorus precursors used to synthesize HA powder were calcium hydroxide, Ca(OH) 2 , and di-ammonium hydrogen phosphate, (NH 4 ) 2 HPO 4 . The HA powder was mixed with distilled water at certain powder-to-liquid (P/L) ratios. In this study, the P/L ratios were varied at 1.3 and 1.7. PEG was added into CPC with the P/L ratio of 1.3, and it was adjusted at 1 and 5 wt%. The results of this study revealed that higher P/L ratio contributed to the decreased in porosity of CPC. Meanwhile, the addition of PEG increased the porosity of CPC. This is significant for cells adhesion and proliferation, such that cell proliferate faster and better adhesion with the incorporation of PEG into CPC. The cell culture on CPC has proven that the fabricated CPC shows no toxic reaction and cells grow well. © BEIESP. 2020-02-03T03:30:31Z 2020-02-03T03:30:31Z 2019 Article http://dspace.uniten.edu.my/jspui/handle/123456789/13122 en
institution Universiti Tenaga Nasional
building UNITEN Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tenaga Nasional
content_source UNITEN Institutional Repository
url_provider http://dspace.uniten.edu.my/
language English
description Calcium phosphate cement (CPC) for injectable bone cement application has been developed in this study. The CPC was produced using a novel wet chemical precipitation method derived hydroxyapatite (HA) powder. The calcium and phosphorus precursors used to synthesize HA powder were calcium hydroxide, Ca(OH) 2 , and di-ammonium hydrogen phosphate, (NH 4 ) 2 HPO 4 . The HA powder was mixed with distilled water at certain powder-to-liquid (P/L) ratios. In this study, the P/L ratios were varied at 1.3 and 1.7. PEG was added into CPC with the P/L ratio of 1.3, and it was adjusted at 1 and 5 wt%. The results of this study revealed that higher P/L ratio contributed to the decreased in porosity of CPC. Meanwhile, the addition of PEG increased the porosity of CPC. This is significant for cells adhesion and proliferation, such that cell proliferate faster and better adhesion with the incorporation of PEG into CPC. The cell culture on CPC has proven that the fabricated CPC shows no toxic reaction and cells grow well. © BEIESP.
format Article
author Hablee, S.
Samsudin, N.
Sopyan, I.
Mel, M.
Salleh, H.M.
Rahman, M.M.
Hashim, Y.Z.H.-Y.
Raus, R.A.
spellingShingle Hablee, S.
Samsudin, N.
Sopyan, I.
Mel, M.
Salleh, H.M.
Rahman, M.M.
Hashim, Y.Z.H.-Y.
Raus, R.A.
Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance
author_facet Hablee, S.
Samsudin, N.
Sopyan, I.
Mel, M.
Salleh, H.M.
Rahman, M.M.
Hashim, Y.Z.H.-Y.
Raus, R.A.
author_sort Hablee, S.
title Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance
title_short Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance
title_full Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance
title_fullStr Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance
title_full_unstemmed Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance
title_sort calcium phosphate /poly (ethylene glycol) bone cement: cell culture performance
publishDate 2020
url http://dspace.uniten.edu.my/jspui/handle/123456789/13122
_version_ 1678595893032386560
score 13.211869

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