Cover Image

Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells

Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome rearrangements in NPC is unclear, various mechanisms including activation of caspase-activate...

Full description

Saved in:
Bibliographic Details
Main Authors: Siaw, Shi Boon, Sim, S.P
Format: E-Article
Language:English
Published: BioMed Central 2015
Subjects:
R Medicine (General)
Online Access:http://ir.unimas.my/id/eprint/8231/1/NO%2071%20Inhibitor%20of%20caspase-activated%20DNase%20expression%20enhances%20caspase-activated%20DNase%20expression%20and%20inhibits%20oxidative%20stress%20-%20abstrak.pdf
http://ir.unimas.my/id/eprint/8231/
http://www.cancerci.com/content/15/1/54
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.unimas.ir.8231
record_format eprints
spelling my.unimas.ir.82312017-02-06T07:32:17Z http://ir.unimas.my/id/eprint/8231/ Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells Siaw, Shi Boon Sim, S.P R Medicine (General) Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome rearrangements in NPC is unclear, various mechanisms including activation of caspase-activated DNase (CAD) were proposed to contribute to chromosome rearrangements in leukaemia. Activation of CAD can be initiated by multiple agents, including oxidative stress, which is well implicated in carcinogenesis. CAD is the main enzyme that causes DNA fragmentation during apoptosis, and CAD is also implicated in promoting cell differentiation. In view of the role of oxidative stress in carcinogenesis and CAD activation, and since CAD was suggested to contribute to chromosome rearrangement in leukaemia, we hypothesise that oxidative stress-induced CAD activation could be one of the mechanisms that leads to chromosome rearrangements in NPC. BioMed Central 2015 E-Article PeerReviewed text en http://ir.unimas.my/id/eprint/8231/1/NO%2071%20Inhibitor%20of%20caspase-activated%20DNase%20expression%20enhances%20caspase-activated%20DNase%20expression%20and%20inhibits%20oxidative%20stress%20-%20abstrak.pdf Siaw, Shi Boon and Sim, S.P (2015) Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells. Cancer Cell International, 15 (54). ISSN 1475-2867 http://www.cancerci.com/content/15/1/54 doi:10.1186/s12935-015-0205-1
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Siaw, Shi Boon
Sim, S.P
Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells
description Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome rearrangements in NPC is unclear, various mechanisms including activation of caspase-activated DNase (CAD) were proposed to contribute to chromosome rearrangements in leukaemia. Activation of CAD can be initiated by multiple agents, including oxidative stress, which is well implicated in carcinogenesis. CAD is the main enzyme that causes DNA fragmentation during apoptosis, and CAD is also implicated in promoting cell differentiation. In view of the role of oxidative stress in carcinogenesis and CAD activation, and since CAD was suggested to contribute to chromosome rearrangement in leukaemia, we hypothesise that oxidative stress-induced CAD activation could be one of the mechanisms that leads to chromosome rearrangements in NPC.
format E-Article
author Siaw, Shi Boon
Sim, S.P
author_facet Siaw, Shi Boon
Sim, S.P
author_sort Siaw, Shi Boon
title Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells
title_short Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells
title_full Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells
title_fullStr Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells
title_full_unstemmed Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells
title_sort inhibitor of caspase-activated dnase expression enhances caspase-activated dnase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells
publisher BioMed Central
publishDate 2015
url http://ir.unimas.my/id/eprint/8231/1/NO%2071%20Inhibitor%20of%20caspase-activated%20DNase%20expression%20enhances%20caspase-activated%20DNase%20expression%20and%20inhibits%20oxidative%20stress%20-%20abstrak.pdf
http://ir.unimas.my/id/eprint/8231/
http://www.cancerci.com/content/15/1/54
_version_ 1644510485836464128
score 13.211869

Similar Items