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Synthesis, characterization and antibacterial activity of bis thiourea derivatives

A series of bis(thiourea) derivatives were successfully synthesized by reaction of benzene-1,4-dicarbonyl isothiocyanate intermediates, with amino acid and aromatic amine to afford thiourea 20-24 with overall yields of 11–58%. The structures of the synthesized compounds were characterized by infra...

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Bibliographic Details
Main Author: Ainaa Nadiah, Abd Halim
Format: Final Year Project Report
Language:English
Published: Universiti Malaysia Sarawak, UNIMAS 2013
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://ir.unimas.my/id/eprint/7608/8/Ainaa%20Nadiah%20Binti%20Abd%20Halim%20ft.pdf
http://ir.unimas.my/id/eprint/7608/
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spelling my.unimas.ir.76082024-02-27T08:21:44Z http://ir.unimas.my/id/eprint/7608/ Synthesis, characterization and antibacterial activity of bis thiourea derivatives Ainaa Nadiah, Abd Halim Q Science (General) QD Chemistry A series of bis(thiourea) derivatives were successfully synthesized by reaction of benzene-1,4-dicarbonyl isothiocyanate intermediates, with amino acid and aromatic amine to afford thiourea 20-24 with overall yields of 11–58%. The structures of the synthesized compounds were characterized by infra red spectroscopy (FTIR), 13C nuclear magnetic resonance (NMR), and 1H NMR spectroscopy. The antibacterial activities of thiourea 20-24 were investigated on gram-negative bacteria, Escherichia coli using turbidimetric kinetic method. Minimum inhibition concentration (MIC) values of the compounds toward the bacteria were determined. The result obtained in this study indicated that only N1,N4- bis(phenylcarbamothioyl)terephthalamide 22 showed antibacterial activity against E. coli compared with other synthesized compounds. Universiti Malaysia Sarawak, UNIMAS 2013 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/7608/8/Ainaa%20Nadiah%20Binti%20Abd%20Halim%20ft.pdf Ainaa Nadiah, Abd Halim (2013) Synthesis, characterization and antibacterial activity of bis thiourea derivatives. [Final Year Project Report] (Unpublished)
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Ainaa Nadiah, Abd Halim
Synthesis, characterization and antibacterial activity of bis thiourea derivatives
description A series of bis(thiourea) derivatives were successfully synthesized by reaction of benzene-1,4-dicarbonyl isothiocyanate intermediates, with amino acid and aromatic amine to afford thiourea 20-24 with overall yields of 11–58%. The structures of the synthesized compounds were characterized by infra red spectroscopy (FTIR), 13C nuclear magnetic resonance (NMR), and 1H NMR spectroscopy. The antibacterial activities of thiourea 20-24 were investigated on gram-negative bacteria, Escherichia coli using turbidimetric kinetic method. Minimum inhibition concentration (MIC) values of the compounds toward the bacteria were determined. The result obtained in this study indicated that only N1,N4- bis(phenylcarbamothioyl)terephthalamide 22 showed antibacterial activity against E. coli compared with other synthesized compounds.
format Final Year Project Report
author Ainaa Nadiah, Abd Halim
author_facet Ainaa Nadiah, Abd Halim
author_sort Ainaa Nadiah, Abd Halim
title Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_short Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_full Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_fullStr Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_full_unstemmed Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_sort synthesis, characterization and antibacterial activity of bis thiourea derivatives
publisher Universiti Malaysia Sarawak, UNIMAS
publishDate 2013
url http://ir.unimas.my/id/eprint/7608/8/Ainaa%20Nadiah%20Binti%20Abd%20Halim%20ft.pdf
http://ir.unimas.my/id/eprint/7608/
_version_ 1792160574525669376
score 13.211869

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