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Clinical features, diagnosis, and management of enterovirus 71

Although poliomyelitis has been mostly eradicated worldwide, large outbreaks of the related enterovirus 71 have been seen in Asia-Pacific countries in the past 10 years. This virus mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute fla...

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Main Authors: Ooi, Mong How, Wong, See Chang, Lewthwaite, Penny, Cardosa, Mary Jane, Solomon, Tom
Format: Article
Language:English
Published: Science Direct 2010
Subjects:
Q Science (General)
QR355 Virology
R Medicine (General)
Online Access:http://ir.unimas.my/id/eprint/7019/2/Clinical%20features.pdf
http://ir.unimas.my/id/eprint/7019/
http://www.sciencedirect.com/science/article/pii/S147444221070209X
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spelling my.unimas.ir.70192022-09-05T01:56:31Z http://ir.unimas.my/id/eprint/7019/ Clinical features, diagnosis, and management of enterovirus 71 Ooi, Mong How Wong, See Chang Lewthwaite, Penny Cardosa, Mary Jane Solomon, Tom Q Science (General) QR355 Virology R Medicine (General) Although poliomyelitis has been mostly eradicated worldwide, large outbreaks of the related enterovirus 71 have been seen in Asia-Pacific countries in the past 10 years. This virus mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute flaccid paralysis, brainstem encephalitis, and other severe systemic disorders, including especially pulmonary oedema and cardiorespiratory collapse. Clinical predictors of severe disease include high temperature and lethargy, and lumbar puncture might reveal pleocytosis. Many diagnostic tests are available, but PCR of throat swabs and vesicle fluid, if available, is among the most efficient. Features of inflammation, particularly in the anterior horns of the spinal cord, the dorsal pons, and the medulla can be clearly seen on MRI. No established antiviral treatment is available. Intravenous immunoglobulin seems to be beneficial in severe disease, perhaps through non-specific anti-inflammatory mechanisms, but has not been tested in any formal trials. Milrinone might be helpful in patients with cardiac dysfunction. Science Direct 2010-11 Article PeerReviewed text en http://ir.unimas.my/id/eprint/7019/2/Clinical%20features.pdf Ooi, Mong How and Wong, See Chang and Lewthwaite, Penny and Cardosa, Mary Jane and Solomon, Tom (2010) Clinical features, diagnosis, and management of enterovirus 71. The Lancet Neurology, 9 (11). pp. 1097-1105. ISSN 1474-4422 http://www.sciencedirect.com/science/article/pii/S147444221070209X doi:10.1016/S1474-4422(10)70209-X
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
QR355 Virology
R Medicine (General)
spellingShingle Q Science (General)
QR355 Virology
R Medicine (General)
Ooi, Mong How
Wong, See Chang
Lewthwaite, Penny
Cardosa, Mary Jane
Solomon, Tom
Clinical features, diagnosis, and management of enterovirus 71
description Although poliomyelitis has been mostly eradicated worldwide, large outbreaks of the related enterovirus 71 have been seen in Asia-Pacific countries in the past 10 years. This virus mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute flaccid paralysis, brainstem encephalitis, and other severe systemic disorders, including especially pulmonary oedema and cardiorespiratory collapse. Clinical predictors of severe disease include high temperature and lethargy, and lumbar puncture might reveal pleocytosis. Many diagnostic tests are available, but PCR of throat swabs and vesicle fluid, if available, is among the most efficient. Features of inflammation, particularly in the anterior horns of the spinal cord, the dorsal pons, and the medulla can be clearly seen on MRI. No established antiviral treatment is available. Intravenous immunoglobulin seems to be beneficial in severe disease, perhaps through non-specific anti-inflammatory mechanisms, but has not been tested in any formal trials. Milrinone might be helpful in patients with cardiac dysfunction.
format Article
author Ooi, Mong How
Wong, See Chang
Lewthwaite, Penny
Cardosa, Mary Jane
Solomon, Tom
author_facet Ooi, Mong How
Wong, See Chang
Lewthwaite, Penny
Cardosa, Mary Jane
Solomon, Tom
author_sort Ooi, Mong How
title Clinical features, diagnosis, and management of enterovirus 71
title_short Clinical features, diagnosis, and management of enterovirus 71
title_full Clinical features, diagnosis, and management of enterovirus 71
title_fullStr Clinical features, diagnosis, and management of enterovirus 71
title_full_unstemmed Clinical features, diagnosis, and management of enterovirus 71
title_sort clinical features, diagnosis, and management of enterovirus 71
publisher Science Direct
publishDate 2010
url http://ir.unimas.my/id/eprint/7019/2/Clinical%20features.pdf
http://ir.unimas.my/id/eprint/7019/
http://www.sciencedirect.com/science/article/pii/S147444221070209X
_version_ 1743110936046075904
score 13.211869

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