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Chromosome fragility in nasopharyngeal carcinoma (NPC)

Nasopharyngeal carcinoma (NPC) is reported to be associated with Epstein-Barr virus (EBV) infection as well as genetic alterations in the nasopharyngeal epithelium. These include common deletions at 3p, 9p, 11q, 13q and 14q; and additions at 1q, 3q, 8q, 11q and 12p. The 11q23 which contains the Mixe...

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Main Author: Yee, Peter Han Chung
Format: Thesis
Language:English
Published: Universiti Malaysia Sarawak, (UNIMAS) 2007
Subjects:
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:http://ir.unimas.my/id/eprint/603/2/Peter%20Han%20Chung.pdf
http://ir.unimas.my/id/eprint/603/
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spelling my.unimas.ir.6032023-06-12T07:04:58Z http://ir.unimas.my/id/eprint/603/ Chromosome fragility in nasopharyngeal carcinoma (NPC) Yee, Peter Han Chung RC0254 Neoplasms. Tumors. Oncology (including Cancer) Nasopharyngeal carcinoma (NPC) is reported to be associated with Epstein-Barr virus (EBV) infection as well as genetic alterations in the nasopharyngeal epithelium. These include common deletions at 3p, 9p, 11q, 13q and 14q; and additions at 1q, 3q, 8q, 11q and 12p. The 11q23 which contains the Mixed Lineage Leukaemia (MLL) gene appears to be the common region of deletion. Till date, the mechanism of chromosome rearrangements (addition or deletion) is unknown. However, apoptosis induced chromosome break within the MLL gne have been reported in the leukaemia cells. Thus, the aim of this project is to elucidate the role of apoptosis /EBV-induced apoptosis which may lead to chromosomal rearrangement in NPC. Materials and Methods: NPC cell line was treated with apoptotic stimuli and purified DNA fragments were separated on agarose gel. Universiti Malaysia Sarawak, (UNIMAS) 2007 Thesis NonPeerReviewed text en http://ir.unimas.my/id/eprint/603/2/Peter%20Han%20Chung.pdf Yee, Peter Han Chung (2007) Chromosome fragility in nasopharyngeal carcinoma (NPC). Masters thesis, Universiti Malaysia Sarawak (UNIMAS).
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Yee, Peter Han Chung
Chromosome fragility in nasopharyngeal carcinoma (NPC)
description Nasopharyngeal carcinoma (NPC) is reported to be associated with Epstein-Barr virus (EBV) infection as well as genetic alterations in the nasopharyngeal epithelium. These include common deletions at 3p, 9p, 11q, 13q and 14q; and additions at 1q, 3q, 8q, 11q and 12p. The 11q23 which contains the Mixed Lineage Leukaemia (MLL) gene appears to be the common region of deletion. Till date, the mechanism of chromosome rearrangements (addition or deletion) is unknown. However, apoptosis induced chromosome break within the MLL gne have been reported in the leukaemia cells. Thus, the aim of this project is to elucidate the role of apoptosis /EBV-induced apoptosis which may lead to chromosomal rearrangement in NPC. Materials and Methods: NPC cell line was treated with apoptotic stimuli and purified DNA fragments were separated on agarose gel.
format Thesis
author Yee, Peter Han Chung
author_facet Yee, Peter Han Chung
author_sort Yee, Peter Han Chung
title Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_short Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_full Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_fullStr Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_full_unstemmed Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_sort chromosome fragility in nasopharyngeal carcinoma (npc)
publisher Universiti Malaysia Sarawak, (UNIMAS)
publishDate 2007
url http://ir.unimas.my/id/eprint/603/2/Peter%20Han%20Chung.pdf
http://ir.unimas.my/id/eprint/603/
_version_ 1769847602243698688
score 13.211869

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