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Case Series of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression

Introduction: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation therapy and The United States Food and Drug Administration (FDA) approved the use of rTMS for the treatment of major depressive disorder (MDD) in 2008. Meta-analyses have shown that patients...

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Main Authors: Gue, Kay Lyn, Ting, Chuong Hock
Format: Article
Language:English
Published: FAKULTI PERUBATAN DAN SAINS KESIHATAN, UPM 2024
Subjects:
R Medicine (General)
Online Access:http://ir.unimas.my/id/eprint/44899/3/Case%20Series.pdf
http://ir.unimas.my/id/eprint/44899/
https://medic.upm.edu.my/jurnal_kami/volume_20_2024/mjmhs_vol20_no_3_may_2024-78743
https://doi.org/10.47836/mjmhs.20.3.48
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spelling my.unimas.ir.448992024-05-30T02:05:05Z http://ir.unimas.my/id/eprint/44899/ Case Series of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression Gue, Kay Lyn Ting, Chuong Hock R Medicine (General) Introduction: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation therapy and The United States Food and Drug Administration (FDA) approved the use of rTMS for the treatment of major depressive disorder (MDD) in 2008. Meta-analyses have shown that patients with treatment-resistant depression (TRD) showed clinically significant improvement after treatment with rTMS but studies on the efficacy of rTMS in special populations such as the elderly are still very limited. Case Series: This case series aimed to report the efficacy of rTMS on treatment-resistant depression in patients of diverse ages in Hospital Sentosa Kuching, Malaysia. Four patients with treatment-resistant depression, aged 17 to 73 years old, completed the course of rTMS. All patients received 20 sessions of rTMS, with 120% motor threshold, 10 Hz rTMS, 3000 pulses per session, and five times per week. The outcome of treatment was measured using The Montgomery–Åsberg Depression Rating Scale (MADRS) and responders were defined as having ≥ 50% reduction in score. Conclusion: Two patients responded to the treatment and two elderly patients did not respond to the rTMS treatment, but it was well tolerated by all patients. rTMS can be a promising treatment option for TRD and more research may be needed to determine the most effective treatment protocol. FAKULTI PERUBATAN DAN SAINS KESIHATAN, UPM 2024 Article PeerReviewed text en http://ir.unimas.my/id/eprint/44899/3/Case%20Series.pdf Gue, Kay Lyn and Ting, Chuong Hock (2024) Case Series of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression. Malaysian Journal of Medicine and Health Sciences, 20 (3). pp. 359-362. ISSN 2636-9346 https://medic.upm.edu.my/jurnal_kami/volume_20_2024/mjmhs_vol20_no_3_may_2024-78743 https://doi.org/10.47836/mjmhs.20.3.48
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Gue, Kay Lyn
Ting, Chuong Hock
Case Series of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
description Introduction: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation therapy and The United States Food and Drug Administration (FDA) approved the use of rTMS for the treatment of major depressive disorder (MDD) in 2008. Meta-analyses have shown that patients with treatment-resistant depression (TRD) showed clinically significant improvement after treatment with rTMS but studies on the efficacy of rTMS in special populations such as the elderly are still very limited. Case Series: This case series aimed to report the efficacy of rTMS on treatment-resistant depression in patients of diverse ages in Hospital Sentosa Kuching, Malaysia. Four patients with treatment-resistant depression, aged 17 to 73 years old, completed the course of rTMS. All patients received 20 sessions of rTMS, with 120% motor threshold, 10 Hz rTMS, 3000 pulses per session, and five times per week. The outcome of treatment was measured using The Montgomery–Åsberg Depression Rating Scale (MADRS) and responders were defined as having ≥ 50% reduction in score. Conclusion: Two patients responded to the treatment and two elderly patients did not respond to the rTMS treatment, but it was well tolerated by all patients. rTMS can be a promising treatment option for TRD and more research may be needed to determine the most effective treatment protocol.
format Article
author Gue, Kay Lyn
Ting, Chuong Hock
author_facet Gue, Kay Lyn
Ting, Chuong Hock
author_sort Gue, Kay Lyn
title Case Series of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
title_short Case Series of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
title_full Case Series of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
title_fullStr Case Series of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
title_full_unstemmed Case Series of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
title_sort case series of repetitive transcranial magnetic stimulation in treatment-resistant depression
publisher FAKULTI PERUBATAN DAN SAINS KESIHATAN, UPM
publishDate 2024
url http://ir.unimas.my/id/eprint/44899/3/Case%20Series.pdf
http://ir.unimas.my/id/eprint/44899/
https://medic.upm.edu.my/jurnal_kami/volume_20_2024/mjmhs_vol20_no_3_may_2024-78743
https://doi.org/10.47836/mjmhs.20.3.48
_version_ 1800730214352814080
score 13.211869

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