صورة الغلاف

Male Systemic Lupus Erythematosus: Gender Differences in Clinical Characteristics

Introduction: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with a higher prevalence in women. The aetiology for this gender difference is unknown, but several studies have shown that despite the higher prevalence of SLE in women, men with SLE have more renal involvement a...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Sharifah Aishah, Wan Mohamad Akbar, Teh, Cheng Lay, Cheong, Yaw Kiet, Ling, Guo Rey, Chuah, Seow Lin, Ahmad Tirmizi, Jobli
التنسيق: مقال
اللغة:English
منشور في: MRE Press 2023
الموضوعات:
R Medicine (General)
الوصول للمادة أونلاين:http://ir.unimas.my/id/eprint/44024/1/MHWC%202023%20proceeding%20abstracts.pdf
http://ir.unimas.my/id/eprint/44024/
https://www.jomh.org/articles/10.22514/jomh.2023.139
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id my.unimas.ir.44024
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spelling my.unimas.ir.440242024-01-08T01:28:12Z http://ir.unimas.my/id/eprint/44024/ Male Systemic Lupus Erythematosus: Gender Differences in Clinical Characteristics Sharifah Aishah, Wan Mohamad Akbar Teh, Cheng Lay Cheong, Yaw Kiet Ling, Guo Rey Chuah, Seow Lin Ahmad Tirmizi, Jobli R Medicine (General) Introduction: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with a higher prevalence in women. The aetiology for this gender difference is unknown, but several studies have shown that despite the higher prevalence of SLE in women, men with SLE have more renal involvement and more severe disease than women. Aim: To examine the clinical characteristics of male SLE patients, and the gender difference between men and women with SLE. Methods: SLE patients in rheumatology units in Sarawak General Hospital and Sibu Hospital were included in the study from July 2018 until November 2021, and the differences in demographics, age at onset, clinical manifestations, and SLE damage index were examined. All patients fulfilled the 2012 Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria for Systemic Lupus Erythematosus. Results: There were 866 patients, with 779 (90%) women and 87 (10%) men. There were more smokers among men (18 (20.7%) men vs. 12 (1.5%) women, p < 0.01). Men had significantly more renal involvement (58 (66.7%) men vs. 420 (53.9%) women, p = 0.02). Men also had more severe disease at SLE diagnosis (58 (66.7%) men vs. 421 (54.0%) women, p = 0.03). Women had significantly more oral or nasal ulcers (330 (42.3%) women vs. 25 (28.7%) men, p = 0.01), non-scarring alopecia (451 (57.8%) women vs. 25 (28.7%) men, p < 0.01), arthritis (319 (40.9%) women vs. 26 (29.9%) men, p = 0.05), and leucopenia (403 (51.7%) women vs. 35 (40.2%) men, p = 0.04). There were no significant differences in mean age at SLE diagnosis (30.2 ± 13.2 years in women vs. 30.4 ± 13.1 years in men, p = 0.9). There were no difference in deaths, with 74 (9.5%) deaths among women and 13 (14.9%) among men, p = 0.1. The presence of disease damage (SLE damage index (SLICC SDI) score >1) did not differ significantly between men and women (men 35 (40.2%) vs. women 294 (37.7%), p = 0.65). However, there was a significant statistical difference seen between men and women in individual damage index items (end stage renal failure, myocardial infarction, gastrointestinal infarction and extensive skin scarring). Conclusions: Male SLE patients tend to have more severe disease at SLE presentation, more renal involvement and more disease damage compared to female SLE patients. MRE Press 2023 Article PeerReviewed text en http://ir.unimas.my/id/eprint/44024/1/MHWC%202023%20proceeding%20abstracts.pdf Sharifah Aishah, Wan Mohamad Akbar and Teh, Cheng Lay and Cheong, Yaw Kiet and Ling, Guo Rey and Chuah, Seow Lin and Ahmad Tirmizi, Jobli (2023) Male Systemic Lupus Erythematosus: Gender Differences in Clinical Characteristics. Journal of Men’s Health, 19 (12). p. 128. ISSN 1875-6867 https://www.jomh.org/articles/10.22514/jomh.2023.139 DOI: 10.22514/jomh.2023.139
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Sharifah Aishah, Wan Mohamad Akbar
Teh, Cheng Lay
Cheong, Yaw Kiet
Ling, Guo Rey
Chuah, Seow Lin
Ahmad Tirmizi, Jobli
Male Systemic Lupus Erythematosus: Gender Differences in Clinical Characteristics
description Introduction: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with a higher prevalence in women. The aetiology for this gender difference is unknown, but several studies have shown that despite the higher prevalence of SLE in women, men with SLE have more renal involvement and more severe disease than women. Aim: To examine the clinical characteristics of male SLE patients, and the gender difference between men and women with SLE. Methods: SLE patients in rheumatology units in Sarawak General Hospital and Sibu Hospital were included in the study from July 2018 until November 2021, and the differences in demographics, age at onset, clinical manifestations, and SLE damage index were examined. All patients fulfilled the 2012 Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria for Systemic Lupus Erythematosus. Results: There were 866 patients, with 779 (90%) women and 87 (10%) men. There were more smokers among men (18 (20.7%) men vs. 12 (1.5%) women, p < 0.01). Men had significantly more renal involvement (58 (66.7%) men vs. 420 (53.9%) women, p = 0.02). Men also had more severe disease at SLE diagnosis (58 (66.7%) men vs. 421 (54.0%) women, p = 0.03). Women had significantly more oral or nasal ulcers (330 (42.3%) women vs. 25 (28.7%) men, p = 0.01), non-scarring alopecia (451 (57.8%) women vs. 25 (28.7%) men, p < 0.01), arthritis (319 (40.9%) women vs. 26 (29.9%) men, p = 0.05), and leucopenia (403 (51.7%) women vs. 35 (40.2%) men, p = 0.04). There were no significant differences in mean age at SLE diagnosis (30.2 ± 13.2 years in women vs. 30.4 ± 13.1 years in men, p = 0.9). There were no difference in deaths, with 74 (9.5%) deaths among women and 13 (14.9%) among men, p = 0.1. The presence of disease damage (SLE damage index (SLICC SDI) score >1) did not differ significantly between men and women (men 35 (40.2%) vs. women 294 (37.7%), p = 0.65). However, there was a significant statistical difference seen between men and women in individual damage index items (end stage renal failure, myocardial infarction, gastrointestinal infarction and extensive skin scarring). Conclusions: Male SLE patients tend to have more severe disease at SLE presentation, more renal involvement and more disease damage compared to female SLE patients.
format Article
author Sharifah Aishah, Wan Mohamad Akbar
Teh, Cheng Lay
Cheong, Yaw Kiet
Ling, Guo Rey
Chuah, Seow Lin
Ahmad Tirmizi, Jobli
author_facet Sharifah Aishah, Wan Mohamad Akbar
Teh, Cheng Lay
Cheong, Yaw Kiet
Ling, Guo Rey
Chuah, Seow Lin
Ahmad Tirmizi, Jobli
author_sort Sharifah Aishah, Wan Mohamad Akbar
title Male Systemic Lupus Erythematosus: Gender Differences in Clinical Characteristics
title_short Male Systemic Lupus Erythematosus: Gender Differences in Clinical Characteristics
title_full Male Systemic Lupus Erythematosus: Gender Differences in Clinical Characteristics
title_fullStr Male Systemic Lupus Erythematosus: Gender Differences in Clinical Characteristics
title_full_unstemmed Male Systemic Lupus Erythematosus: Gender Differences in Clinical Characteristics
title_sort male systemic lupus erythematosus: gender differences in clinical characteristics
publisher MRE Press
publishDate 2023
url http://ir.unimas.my/id/eprint/44024/1/MHWC%202023%20proceeding%20abstracts.pdf
http://ir.unimas.my/id/eprint/44024/
https://www.jomh.org/articles/10.22514/jomh.2023.139
_version_ 1787519574733750272
score 13.251813

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