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A Review of the Ethnomedicinal, Phytochemical, and Anticancer Properties of Melicope Species

The genus Melicope, which consists of 230 species, stands out as the largest genus within the Rutaceae family. Melicope species are characterized by their evergreen nature and can range from shrubs to predominantly dioecious trees. The Melicope species have been utilized in traditional medicine to a...

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Main Authors: Idris, Adewale Ahmed, Md. Sanower, Hossain, Lim, Pei Cee, Nor Hisam, Zamakshshari
Format: Article
Language:English
Published: John Wiley & Sons, Inc 2023
Subjects:
QD Chemistry
RM Therapeutics. Pharmacology
Online Access:http://ir.unimas.my/id/eprint/43525/3/A%20Review.pdf
http://ir.unimas.my/id/eprint/43525/
https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202300952
https://doi.org/10.1002/cbdv.202300952
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id my.unimas.ir.43525
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spelling my.unimas.ir.435252023-12-04T07:45:18Z http://ir.unimas.my/id/eprint/43525/ A Review of the Ethnomedicinal, Phytochemical, and Anticancer Properties of Melicope Species Idris, Adewale Ahmed Md. Sanower, Hossain Lim, Pei Cee Nor Hisam, Zamakshshari QD Chemistry RM Therapeutics. Pharmacology The genus Melicope, which consists of 230 species, stands out as the largest genus within the Rutaceae family. Melicope species are characterized by their evergreen nature and can range from shrubs to predominantly dioecious trees. The Melicope species have been utilized in traditional medicine to address a wide range of ailments, including fever, colds, cramps, and inflammation. These plants have gained significant attention due to their noteworthy ethnopharmacological and ethnomedicinal significance. Researchers have isolated numerous biologically active secondary metabolites from different Melicope species, which include polymethoxylated flavonoids, furanocoumarins, acetophenones, benzenoids, and quinolone alkaloids. These compounds exhibit diverse biological activities, such as antibacterial, antidiabetic, antifungal, and antiproliferative properties against human cancer cell lines. This review provides an update on the chemical constituents of the selected species of Melicope. The study also highlights the anticancer and cytotoxicity properties of the plant extracts and phytochemical constituents from Melicope species. Furthermore, the molecular mechanisms underlying the anticancer effects are elucidated. Overall, this review contributes to understanding the significant pharmacological potential of Melicope species and unlocking their chemical composition, emphasizing their relevance in the development of therapeutic agents, particularly in the field of cancer research. John Wiley & Sons, Inc 2023 Article PeerReviewed text en http://ir.unimas.my/id/eprint/43525/3/A%20Review.pdf Idris, Adewale Ahmed and Md. Sanower, Hossain and Lim, Pei Cee and Nor Hisam, Zamakshshari (2023) A Review of the Ethnomedicinal, Phytochemical, and Anticancer Properties of Melicope Species. Chemistry & Biodiversity. pp. 1-9. ISSN 1612-1872 https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202300952 https://doi.org/10.1002/cbdv.202300952
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic QD Chemistry
RM Therapeutics. Pharmacology
spellingShingle QD Chemistry
RM Therapeutics. Pharmacology
Idris, Adewale Ahmed
Md. Sanower, Hossain
Lim, Pei Cee
Nor Hisam, Zamakshshari
A Review of the Ethnomedicinal, Phytochemical, and Anticancer Properties of Melicope Species
description The genus Melicope, which consists of 230 species, stands out as the largest genus within the Rutaceae family. Melicope species are characterized by their evergreen nature and can range from shrubs to predominantly dioecious trees. The Melicope species have been utilized in traditional medicine to address a wide range of ailments, including fever, colds, cramps, and inflammation. These plants have gained significant attention due to their noteworthy ethnopharmacological and ethnomedicinal significance. Researchers have isolated numerous biologically active secondary metabolites from different Melicope species, which include polymethoxylated flavonoids, furanocoumarins, acetophenones, benzenoids, and quinolone alkaloids. These compounds exhibit diverse biological activities, such as antibacterial, antidiabetic, antifungal, and antiproliferative properties against human cancer cell lines. This review provides an update on the chemical constituents of the selected species of Melicope. The study also highlights the anticancer and cytotoxicity properties of the plant extracts and phytochemical constituents from Melicope species. Furthermore, the molecular mechanisms underlying the anticancer effects are elucidated. Overall, this review contributes to understanding the significant pharmacological potential of Melicope species and unlocking their chemical composition, emphasizing their relevance in the development of therapeutic agents, particularly in the field of cancer research.
format Article
author Idris, Adewale Ahmed
Md. Sanower, Hossain
Lim, Pei Cee
Nor Hisam, Zamakshshari
author_facet Idris, Adewale Ahmed
Md. Sanower, Hossain
Lim, Pei Cee
Nor Hisam, Zamakshshari
author_sort Idris, Adewale Ahmed
title A Review of the Ethnomedicinal, Phytochemical, and Anticancer Properties of Melicope Species
title_short A Review of the Ethnomedicinal, Phytochemical, and Anticancer Properties of Melicope Species
title_full A Review of the Ethnomedicinal, Phytochemical, and Anticancer Properties of Melicope Species
title_fullStr A Review of the Ethnomedicinal, Phytochemical, and Anticancer Properties of Melicope Species
title_full_unstemmed A Review of the Ethnomedicinal, Phytochemical, and Anticancer Properties of Melicope Species
title_sort review of the ethnomedicinal, phytochemical, and anticancer properties of melicope species
publisher John Wiley & Sons, Inc
publishDate 2023
url http://ir.unimas.my/id/eprint/43525/3/A%20Review.pdf
http://ir.unimas.my/id/eprint/43525/
https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202300952
https://doi.org/10.1002/cbdv.202300952
_version_ 1784518376077393920
score 13.211869

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