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UVB Induced Skin Cancer Development in Experimental Mouse Model : A Review

Skin cancer is a widespread global issue, with ultraviolet (UV) radiation being a significant risk factor. Researchers often use the mouse skin cancer model to develop novel therapeutic chemoprevention strategies. This model involves exposing mice to UVB radiation to induce skin arcinogenesis. In t...

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Main Authors: Muhammad Wahizul Haswan, Abdul Aziz, Dayang Fredalina, Basri, Siti Fathiah, Masre, Ahmad Rohi, Ghazali
Format: Article
Language:English
Published: Penerbit UTM Press 2023
Subjects:
Q Science (General)
QL Zoology
R Medicine (General)
RL Dermatology
RM Therapeutics. Pharmacology
Online Access:http://ir.unimas.my/id/eprint/43157/3/UVB.pdf
http://ir.unimas.my/id/eprint/43157/
https://mjfas.utm.my/index.php/mjfas/article/view/2968
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spelling my.unimas.ir.431572023-10-19T06:40:42Z http://ir.unimas.my/id/eprint/43157/ UVB Induced Skin Cancer Development in Experimental Mouse Model : A Review Muhammad Wahizul Haswan, Abdul Aziz Dayang Fredalina, Basri Siti Fathiah, Masre Ahmad Rohi, Ghazali Q Science (General) QL Zoology R Medicine (General) RL Dermatology RM Therapeutics. Pharmacology Skin cancer is a widespread global issue, with ultraviolet (UV) radiation being a significant risk factor. Researchers often use the mouse skin cancer model to develop novel therapeutic chemoprevention strategies. This model involves exposing mice to UVB radiation to induce skin arcinogenesis. In this short communication, we found that 69.57% of studies used female SKH-1 hairless mice, 17.39% used BALB/c mice, 8.69% used Swiss albino mice, and 4.35% used HRS/J hairless mice. All studies used mice aged 5-8 weeks. Different models of mice were exposed to varying doses of UVB radiation. SKH-1 hairless mice received UVB radiation twice a week for 10-18 weeks, while Swiss albino mice were exposed to UVB radiation three times a week for 30 weeks. HRS/J hairless mice received UVB radiation five times a week for 15 weeks. BALB/c mice were treated with DMBA and exposed to UVB radiation for 10-16 weeks to induce skin tumors. However, using SKH-1 hairless mice is costly. In conclusion, we can suggest BALB/c mice treated with DMBA and exposed to UVB radiation three times a week for 16 weeks for UVB-induced skin cancer model, as it is more cost-effective than other hairless mouse models. Penerbit UTM Press 2023-10-19 Article PeerReviewed text en http://ir.unimas.my/id/eprint/43157/3/UVB.pdf Muhammad Wahizul Haswan, Abdul Aziz and Dayang Fredalina, Basri and Siti Fathiah, Masre and Ahmad Rohi, Ghazali (2023) UVB Induced Skin Cancer Development in Experimental Mouse Model : A Review. Malaysian Journal of Fundamental and Applied Sciences, 19 (5). pp. 754-761. ISSN 2289-5981 https://mjfas.utm.my/index.php/mjfas/article/view/2968 DOI: https://doi.org/10.11113/mjfas.v19n5.2968
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
QL Zoology
R Medicine (General)
RL Dermatology
RM Therapeutics. Pharmacology
spellingShingle Q Science (General)
QL Zoology
R Medicine (General)
RL Dermatology
RM Therapeutics. Pharmacology
Muhammad Wahizul Haswan, Abdul Aziz
Dayang Fredalina, Basri
Siti Fathiah, Masre
Ahmad Rohi, Ghazali
UVB Induced Skin Cancer Development in Experimental Mouse Model : A Review
description Skin cancer is a widespread global issue, with ultraviolet (UV) radiation being a significant risk factor. Researchers often use the mouse skin cancer model to develop novel therapeutic chemoprevention strategies. This model involves exposing mice to UVB radiation to induce skin arcinogenesis. In this short communication, we found that 69.57% of studies used female SKH-1 hairless mice, 17.39% used BALB/c mice, 8.69% used Swiss albino mice, and 4.35% used HRS/J hairless mice. All studies used mice aged 5-8 weeks. Different models of mice were exposed to varying doses of UVB radiation. SKH-1 hairless mice received UVB radiation twice a week for 10-18 weeks, while Swiss albino mice were exposed to UVB radiation three times a week for 30 weeks. HRS/J hairless mice received UVB radiation five times a week for 15 weeks. BALB/c mice were treated with DMBA and exposed to UVB radiation for 10-16 weeks to induce skin tumors. However, using SKH-1 hairless mice is costly. In conclusion, we can suggest BALB/c mice treated with DMBA and exposed to UVB radiation three times a week for 16 weeks for UVB-induced skin cancer model, as it is more cost-effective than other hairless mouse models.
format Article
author Muhammad Wahizul Haswan, Abdul Aziz
Dayang Fredalina, Basri
Siti Fathiah, Masre
Ahmad Rohi, Ghazali
author_facet Muhammad Wahizul Haswan, Abdul Aziz
Dayang Fredalina, Basri
Siti Fathiah, Masre
Ahmad Rohi, Ghazali
author_sort Muhammad Wahizul Haswan, Abdul Aziz
title UVB Induced Skin Cancer Development in Experimental Mouse Model : A Review
title_short UVB Induced Skin Cancer Development in Experimental Mouse Model : A Review
title_full UVB Induced Skin Cancer Development in Experimental Mouse Model : A Review
title_fullStr UVB Induced Skin Cancer Development in Experimental Mouse Model : A Review
title_full_unstemmed UVB Induced Skin Cancer Development in Experimental Mouse Model : A Review
title_sort uvb induced skin cancer development in experimental mouse model : a review
publisher Penerbit UTM Press
publishDate 2023
url http://ir.unimas.my/id/eprint/43157/3/UVB.pdf
http://ir.unimas.my/id/eprint/43157/
https://mjfas.utm.my/index.php/mjfas/article/view/2968
_version_ 1781710361043402752
score 13.211869

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