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Toxoplasmosis in HIV and non HIV prisoners in Malaysia

This is the first Malaysian study to determine the trend and risk factors of Toxoplasma gondii infection in HIV and non-HIV among prisoners in terms of socio-demographic and behavioural characteristics, clinical presentations and haematological distributions. Blood samples from 303 participants, co...

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Main Authors: Angal, L., Lim, Y.A.L., Yap, N. P, Romano, Ngui, Amir, A. J., Kamarulzaman, A., Rohela, Mahmud
Format: Article
Language:English
Published: Malaysian Society of Parasitology and Tropical Medicine (MSPTM) 2016
Subjects:
RZ Other systems of medicine
Online Access:http://ir.unimas.my/id/eprint/42158/1/Toxoplasmosis.pdf
http://ir.unimas.my/id/eprint/42158/
https://msptm.org/journal-vol-33-no-1/
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spelling my.unimas.ir.421582023-07-07T02:07:26Z http://ir.unimas.my/id/eprint/42158/ Toxoplasmosis in HIV and non HIV prisoners in Malaysia Angal, L. Lim, Y.A.L. Yap, N. P Romano, Ngui Amir, A. J. Kamarulzaman, A. Rohela, Mahmud RZ Other systems of medicine This is the first Malaysian study to determine the trend and risk factors of Toxoplasma gondii infection in HIV and non-HIV among prisoners in terms of socio-demographic and behavioural characteristics, clinical presentations and haematological distributions. Blood samples from 303 participants, comprising 133 HIV positive and 170 HIV negative inmates were collected in EDTA and plain tubes. Two mls of each blood sample in plain tubes were centrifuged at 1500 rpm for 10 minutes and the sera obtained were subjected to ELISA for detection of Toxoplasma IgM and IgG antibody towards Toxoplasma antigen. Seropositive samples for Toxoplasma IgM or both Toxoplasma IgM and IgG were further tested with Novalisa Toxoplasma gondii IgG avidity test to rule out acute from latent infections. Blood in EDTA tubes were sent to Clinical Diagnostic Lab (CDL), University Malaya Medical Centre (UMMC), Kuala Lumpur for complete blood count and differential count analysis. Overall seroprevalence of anti-T. gondii antibodies was detected in 41.9% (127 out of 303) of the participants. Anti-T. gondii antibodies was detected in 63.2% (84 out of 133) of HIV positive subjects and in 25.3% (43 out of 170) of HIV negative subjects. Seroprevalence of anti-T. gondii antibodies was significantly higher in HIV positive than in HIV negative subjects (OR = 5.06; 95% CI = 3.09-8.30; p < 0.001). The rate of T. gondii seropositivity increased significantly in those aged 40 years and above, HIV positive individuals and those with history of drug abuse. White blood cells (WBCs), neutrophils and basophils counts decreased significantly in those infected with Toxoplasma. Creating awareness about T. gondii infection and follow-up of their status is recommended. Moreover, screening of T. gondii infection in HIV-infected individuals should be considered for better treatment and management, including control and prevention. Malaysian Society of Parasitology and Tropical Medicine (MSPTM) 2016 Article PeerReviewed text en http://ir.unimas.my/id/eprint/42158/1/Toxoplasmosis.pdf Angal, L. and Lim, Y.A.L. and Yap, N. P and Romano, Ngui and Amir, A. J. and Kamarulzaman, A. and Rohela, Mahmud (2016) Toxoplasmosis in HIV and non HIV prisoners in Malaysia. Tropical Biomedicine, 33 (1). pp. 159-169. ISSN 2521-9855 https://msptm.org/journal-vol-33-no-1/
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic RZ Other systems of medicine
spellingShingle RZ Other systems of medicine
Angal, L.
Lim, Y.A.L.
Yap, N. P
Romano, Ngui
Amir, A. J.
Kamarulzaman, A.
Rohela, Mahmud
Toxoplasmosis in HIV and non HIV prisoners in Malaysia
description This is the first Malaysian study to determine the trend and risk factors of Toxoplasma gondii infection in HIV and non-HIV among prisoners in terms of socio-demographic and behavioural characteristics, clinical presentations and haematological distributions. Blood samples from 303 participants, comprising 133 HIV positive and 170 HIV negative inmates were collected in EDTA and plain tubes. Two mls of each blood sample in plain tubes were centrifuged at 1500 rpm for 10 minutes and the sera obtained were subjected to ELISA for detection of Toxoplasma IgM and IgG antibody towards Toxoplasma antigen. Seropositive samples for Toxoplasma IgM or both Toxoplasma IgM and IgG were further tested with Novalisa Toxoplasma gondii IgG avidity test to rule out acute from latent infections. Blood in EDTA tubes were sent to Clinical Diagnostic Lab (CDL), University Malaya Medical Centre (UMMC), Kuala Lumpur for complete blood count and differential count analysis. Overall seroprevalence of anti-T. gondii antibodies was detected in 41.9% (127 out of 303) of the participants. Anti-T. gondii antibodies was detected in 63.2% (84 out of 133) of HIV positive subjects and in 25.3% (43 out of 170) of HIV negative subjects. Seroprevalence of anti-T. gondii antibodies was significantly higher in HIV positive than in HIV negative subjects (OR = 5.06; 95% CI = 3.09-8.30; p < 0.001). The rate of T. gondii seropositivity increased significantly in those aged 40 years and above, HIV positive individuals and those with history of drug abuse. White blood cells (WBCs), neutrophils and basophils counts decreased significantly in those infected with Toxoplasma. Creating awareness about T. gondii infection and follow-up of their status is recommended. Moreover, screening of T. gondii infection in HIV-infected individuals should be considered for better treatment and management, including control and prevention.
format Article
author Angal, L.
Lim, Y.A.L.
Yap, N. P
Romano, Ngui
Amir, A. J.
Kamarulzaman, A.
Rohela, Mahmud
author_facet Angal, L.
Lim, Y.A.L.
Yap, N. P
Romano, Ngui
Amir, A. J.
Kamarulzaman, A.
Rohela, Mahmud
author_sort Angal, L.
title Toxoplasmosis in HIV and non HIV prisoners in Malaysia
title_short Toxoplasmosis in HIV and non HIV prisoners in Malaysia
title_full Toxoplasmosis in HIV and non HIV prisoners in Malaysia
title_fullStr Toxoplasmosis in HIV and non HIV prisoners in Malaysia
title_full_unstemmed Toxoplasmosis in HIV and non HIV prisoners in Malaysia
title_sort toxoplasmosis in hiv and non hiv prisoners in malaysia
publisher Malaysian Society of Parasitology and Tropical Medicine (MSPTM)
publishDate 2016
url http://ir.unimas.my/id/eprint/42158/1/Toxoplasmosis.pdf
http://ir.unimas.my/id/eprint/42158/
https://msptm.org/journal-vol-33-no-1/
_version_ 1772816299118821376
score 13.211869

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