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Routine blood parameters of dengue infected children and adults. A meta-analysis

The World Health Organization (WHO) has revised dengue case classification in 2009 to better reflect the severity of the disease. However, there was no comprehensive meta-analysis of pooled routine blood parameters according to the age or the categories of the 2009 WHO classification. This study aim...

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Main Authors:	Gary KK, Low, Sam Froze, Jiee, Retneswari, Masilamani, Selvanaayagam, Shanmuganathan, Pramila, Rai, Mitali, Manda, Osamudiamen Favour, Omosumwen, Jackob, Kagize, Alex I., Gavino, Aizad, Azahar, Mohammed Abdulrazzaq, Jabbar
Format:	Article
Language:	English
Published:	Taylor & Francis 2023
Subjects:	R Medicine (General)
Online Access:	http://ir.unimas.my/id/eprint/42051/3/Routine%20blood.pdf http://ir.unimas.my/id/eprint/42051/ https://www.tandfonline.com/doi/full/10.1080/20477724.2022.2161864
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spelling	my.unimas.ir.420512023-06-23T08:20:10Z http://ir.unimas.my/id/eprint/42051/ Routine blood parameters of dengue infected children and adults. A meta-analysis Gary KK, Low Sam Froze, Jiee Retneswari, Masilamani Selvanaayagam, Shanmuganathan Pramila, Rai Mitali, Manda Osamudiamen Favour, Omosumwen Jackob, Kagize Alex I., Gavino Aizad, Azahar Mohammed Abdulrazzaq, Jabbar R Medicine (General) The World Health Organization (WHO) has revised dengue case classification in 2009 to better reflect the severity of the disease. However, there was no comprehensive meta-analysis of pooled routine blood parameters according to the age or the categories of the 2009 WHO classification. This study aimed to meta-analyze the routine blood parameters of dengue infected children and adults. Electronic search was performed with eligible articles included for review. Meta-analysis was conducted for six blood parameters stratified into children, adults and all ages, which were further grouped into the three 2009 WHO case classifications (dengue without warning signs, DwoWS; dengue with warning signs, DwWS; severe dengue, SD), non-severe dengue (non-SD) and ‘All’ cases. A total of 55 articles were included in the meta-analysis. Fifteen studies were conducted in the children’s age category, 31 studies in the adult category and nine studies in all ages. The four selected pooled blood parameters for children were white blood cell (WBC) (×103/L) with 5.11 (SD), 5.64 (DwWS), 5.52 (DwoWS) and 4.68 (Non-SD) hematocrit (HCT) (%) with 36.78 (SD), 40.70 (DwWS), 35.00 (DwoWS) and 29.78 (Non-SD) platelet (PLT) (×103/µL) with 78.66 (SD), 108.01 (DwWS), 153.47 (DwoWS) and 108.29 (non-SD); and aspartate aminotransferase (AST) (/µL) with 248.88 (SD), 170.83 (DwWS), 83.24 (DwoWS) and 102.99 (non-SD). For adult, WBC were 4.96 (SD), 6.44 (DwWS), 7.74 (DwoWS) and 3.61 (non-SD); HCT were 39.50 (SD), 39.00 (DwWS), 37.45 (DwoWS) and 41.68 (non-SD); PLT were 49.62 (SD), 96.60 (DwWS), 114.37 (DwoWS) and 71.13 (non-SD); and AST were 399.50 (SD), 141.01 (DwWS), 96.19 (DwoWS) and 118.13 (non-SD). These blood parameters could not differentiate between each dengue severity according to the WHO 2009 classification, SD, DwoWS, DwWS and non-SD, because the timing of blood drawing was not known and there was an overlapping confidence interval among the clinical classification. Hence, these pooled blood parameter values could not be used to guide clinicians in management and did not correlate with severity as in previous scientific literatures and guidelines. Taylor & Francis 2023 Article PeerReviewed text en http://ir.unimas.my/id/eprint/42051/3/Routine%20blood.pdf Gary KK, Low and Sam Froze, Jiee and Retneswari, Masilamani and Selvanaayagam, Shanmuganathan and Pramila, Rai and Mitali, Manda and Osamudiamen Favour, Omosumwen and Jackob, Kagize and Alex I., Gavino and Aizad, Azahar and Mohammed Abdulrazzaq, Jabbar (2023) Routine blood parameters of dengue infected children and adults. A meta-analysis. Pathogens and Global Health. ISSN 2047-7732 https://www.tandfonline.com/doi/full/10.1080/20477724.2022.2161864 doi: 10.1080/20477724.2022.2161864.
institution	Universiti Malaysia Sarawak
building	Centre for Academic Information Services (CAIS)
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sarawak
content_source	UNIMAS Institutional Repository
url_provider	http://ir.unimas.my/
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Gary KK, Low Sam Froze, Jiee Retneswari, Masilamani Selvanaayagam, Shanmuganathan Pramila, Rai Mitali, Manda Osamudiamen Favour, Omosumwen Jackob, Kagize Alex I., Gavino Aizad, Azahar Mohammed Abdulrazzaq, Jabbar Routine blood parameters of dengue infected children and adults. A meta-analysis
description	The World Health Organization (WHO) has revised dengue case classification in 2009 to better reflect the severity of the disease. However, there was no comprehensive meta-analysis of pooled routine blood parameters according to the age or the categories of the 2009 WHO classification. This study aimed to meta-analyze the routine blood parameters of dengue infected children and adults. Electronic search was performed with eligible articles included for review. Meta-analysis was conducted for six blood parameters stratified into children, adults and all ages, which were further grouped into the three 2009 WHO case classifications (dengue without warning signs, DwoWS; dengue with warning signs, DwWS; severe dengue, SD), non-severe dengue (non-SD) and ‘All’ cases. A total of 55 articles were included in the meta-analysis. Fifteen studies were conducted in the children’s age category, 31 studies in the adult category and nine studies in all ages. The four selected pooled blood parameters for children were white blood cell (WBC) (×103/L) with 5.11 (SD), 5.64 (DwWS), 5.52 (DwoWS) and 4.68 (Non-SD) hematocrit (HCT) (%) with 36.78 (SD), 40.70 (DwWS), 35.00 (DwoWS) and 29.78 (Non-SD) platelet (PLT) (×103/µL) with 78.66 (SD), 108.01 (DwWS), 153.47 (DwoWS) and 108.29 (non-SD); and aspartate aminotransferase (AST) (/µL) with 248.88 (SD), 170.83 (DwWS), 83.24 (DwoWS) and 102.99 (non-SD). For adult, WBC were 4.96 (SD), 6.44 (DwWS), 7.74 (DwoWS) and 3.61 (non-SD); HCT were 39.50 (SD), 39.00 (DwWS), 37.45 (DwoWS) and 41.68 (non-SD); PLT were 49.62 (SD), 96.60 (DwWS), 114.37 (DwoWS) and 71.13 (non-SD); and AST were 399.50 (SD), 141.01 (DwWS), 96.19 (DwoWS) and 118.13 (non-SD). These blood parameters could not differentiate between each dengue severity according to the WHO 2009 classification, SD, DwoWS, DwWS and non-SD, because the timing of blood drawing was not known and there was an overlapping confidence interval among the clinical classification. Hence, these pooled blood parameter values could not be used to guide clinicians in management and did not correlate with severity as in previous scientific literatures and guidelines.
format	Article
author	Gary KK, Low Sam Froze, Jiee Retneswari, Masilamani Selvanaayagam, Shanmuganathan Pramila, Rai Mitali, Manda Osamudiamen Favour, Omosumwen Jackob, Kagize Alex I., Gavino Aizad, Azahar Mohammed Abdulrazzaq, Jabbar
author_facet	Gary KK, Low Sam Froze, Jiee Retneswari, Masilamani Selvanaayagam, Shanmuganathan Pramila, Rai Mitali, Manda Osamudiamen Favour, Omosumwen Jackob, Kagize Alex I., Gavino Aizad, Azahar Mohammed Abdulrazzaq, Jabbar
author_sort	Gary KK, Low
title	Routine blood parameters of dengue infected children and adults. A meta-analysis
title_short	Routine blood parameters of dengue infected children and adults. A meta-analysis
title_full	Routine blood parameters of dengue infected children and adults. A meta-analysis
title_fullStr	Routine blood parameters of dengue infected children and adults. A meta-analysis
title_full_unstemmed	Routine blood parameters of dengue infected children and adults. A meta-analysis
title_sort	routine blood parameters of dengue infected children and adults. a meta-analysis
publisher	Taylor & Francis
publishDate	2023
url	http://ir.unimas.my/id/eprint/42051/3/Routine%20blood.pdf http://ir.unimas.my/id/eprint/42051/ https://www.tandfonline.com/doi/full/10.1080/20477724.2022.2161864
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score	13.211869

Routine blood parameters of dengue infected children and adults. A meta-analysis

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