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Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is relatively known as a unique malignancy associated with an oncovirus, Epstein-Barr virus (EBV), displaying genetic, epidemiological and regional distribution properties. Many researches have proved that p53 mutations are involved in NPC, but the precise gene express...

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Bibliographic Details
Main Author: Emmanuella Nina Christina, Wakiman
Format: Final Year Project Report
Language:English
English
Published: Universiti Malaysia Sarawak, (UNIMAS) 2022
Subjects:
QL Zoology
Online Access:http://ir.unimas.my/id/eprint/39812/1/EMMANUELLA%20NINA%20CHRISTINA%2024pgs.pdf
http://ir.unimas.my/id/eprint/39812/4/Emmanuella%20Nina%20Christina%20Wakiman%20ft.pdf
http://ir.unimas.my/id/eprint/39812/
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spelling my.unimas.ir.398122023-07-25T08:14:39Z http://ir.unimas.my/id/eprint/39812/ Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma Emmanuella Nina Christina, Wakiman QL Zoology Nasopharyngeal carcinoma (NPC) is relatively known as a unique malignancy associated with an oncovirus, Epstein-Barr virus (EBV), displaying genetic, epidemiological and regional distribution properties. Many researches have proved that p53 mutations are involved in NPC, but the precise gene expression of p53 is only partially understood. Identification on the dysregulation expression level of p53 in NPC can provide new insight into the future research and pathology of NPC by the discovery of a new prognostic marker. p53 is a tumor suppressor gene that most frequently mutated found in a large variety of human cancer epidemiology. In this study, bibliographical data was conducted fundamentally by Rstudio to study the publication and locality trend of p53 gene family from 2013 to 2022 across the world. As a whole, the data represents that the highest annual scientific production was on 2013, 7924 authors (87.41%) published 1 document each. With respect to citations, 2019 has the highest average article citations per year and the main country in terms of number of publications is China. The result clearly shows that USA is the most cited countries. On the other hand, for gene expression of p53 in NPC, the differential expression level of p53 between NP69 and HK1 are not able to be concluded since the intensity of GAPDH for NP69 and HK1 in Duplicate 1 are not the same. Besides, there is a band presence in GAPDH negative control. Universiti Malaysia Sarawak, (UNIMAS) 2022 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/39812/1/EMMANUELLA%20NINA%20CHRISTINA%2024pgs.pdf text en http://ir.unimas.my/id/eprint/39812/4/Emmanuella%20Nina%20Christina%20Wakiman%20ft.pdf Emmanuella Nina Christina, Wakiman (2022) Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma. [Final Year Project Report] (Unpublished)
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
English
topic QL Zoology
spellingShingle QL Zoology
Emmanuella Nina Christina, Wakiman
Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma
description Nasopharyngeal carcinoma (NPC) is relatively known as a unique malignancy associated with an oncovirus, Epstein-Barr virus (EBV), displaying genetic, epidemiological and regional distribution properties. Many researches have proved that p53 mutations are involved in NPC, but the precise gene expression of p53 is only partially understood. Identification on the dysregulation expression level of p53 in NPC can provide new insight into the future research and pathology of NPC by the discovery of a new prognostic marker. p53 is a tumor suppressor gene that most frequently mutated found in a large variety of human cancer epidemiology. In this study, bibliographical data was conducted fundamentally by Rstudio to study the publication and locality trend of p53 gene family from 2013 to 2022 across the world. As a whole, the data represents that the highest annual scientific production was on 2013, 7924 authors (87.41%) published 1 document each. With respect to citations, 2019 has the highest average article citations per year and the main country in terms of number of publications is China. The result clearly shows that USA is the most cited countries. On the other hand, for gene expression of p53 in NPC, the differential expression level of p53 between NP69 and HK1 are not able to be concluded since the intensity of GAPDH for NP69 and HK1 in Duplicate 1 are not the same. Besides, there is a band presence in GAPDH negative control.
format Final Year Project Report
author Emmanuella Nina Christina, Wakiman
author_facet Emmanuella Nina Christina, Wakiman
author_sort Emmanuella Nina Christina, Wakiman
title Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma
title_short Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma
title_full Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma
title_fullStr Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma
title_full_unstemmed Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma
title_sort bibliographic analysis of p53-gene family and gene expression analysis of p53 in nasopharyngeal carcinoma
publisher Universiti Malaysia Sarawak, (UNIMAS)
publishDate 2022
url http://ir.unimas.my/id/eprint/39812/1/EMMANUELLA%20NINA%20CHRISTINA%2024pgs.pdf
http://ir.unimas.my/id/eprint/39812/4/Emmanuella%20Nina%20Christina%20Wakiman%20ft.pdf
http://ir.unimas.my/id/eprint/39812/
_version_ 1772816292137402368
score 13.211869

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