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Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs

Immature immunity may predispose preterm neonates to infections and necrotizing enterocolitis (NEC). Intravenous antibiotics are frequently given to prevent and treat sepsis, while oral antibiotics are seldom used. We hypothesized that oral antibiotics promote maturation of systemic immunity and del...

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Main Authors: Duc Ninh, Nguyen, Eva, Fuglsang, Pingping, Jiang, Birck, Malene M., Xiaoyu, Pan, Shamrulazhar, Shamzir Kamal, Pors, Susanne E, Gammelgaard, Pernille L, Nielsen, Dennis Sandris, Thymann, Thomas, Levy, Ofer, Frokier, Hanne, Sangild, Per Torp
Format: Article
Language:English
Published: 2015
Subjects:
QL Zoology
QP Physiology
QR Microbiology
S Agriculture (General)
SF Animal culture
Online Access:http://ir.unimas.my/id/eprint/39027/1/Oral%20antibiotics%20increase%20blood%20neutrophil.pdf
http://ir.unimas.my/id/eprint/39027/
https://journals.sagepub.com/doi/10.1177/1753425915615195
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spelling my.unimas.ir.390272022-08-02T06:23:49Z http://ir.unimas.my/id/eprint/39027/ Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs Duc Ninh, Nguyen Eva, Fuglsang Pingping, Jiang Birck, Malene M. Xiaoyu, Pan Shamrulazhar, Shamzir Kamal Pors, Susanne E Gammelgaard, Pernille L Nielsen, Dennis Sandris Thymann, Thomas Levy, Ofer Frokier, Hanne Sangild, Per Torp QL Zoology QP Physiology QR Microbiology S Agriculture (General) SF Animal culture Immature immunity may predispose preterm neonates to infections and necrotizing enterocolitis (NEC). Intravenous antibiotics are frequently given to prevent and treat sepsis, while oral antibiotics are seldom used. We hypothesized that oral antibiotics promote maturation of systemic immunity and delay gut bacterial colonization and thereby protect preterm neonates against both NEC and bacteremia in the immediate postnatal period. Preterm pigs were given formula and administered saline (CON) or broad-spectrum antibiotics orally (ORA) or systemically (SYS) for 5 d after birth. Temporal changes in blood parameters and bacterial composition in the intestine, blood and immune organs were analyzed. Newborn preterm pigs had few blood neutrophils and a high frequency of progenitor cells. Neutrophils gradually matured after preterm birth with increasing CD14 and decreasing CD172a expressions. Preterm neutrophil and monocyte TLR2 expression and TLR2-mediated blood cytokine responses were low relative to adults. ORA pigs showed enhanced blood neutrophil maturation with reduced cell size and CD172a expression. Only ORA pigs, but not SYS pigs, were protected from a high density of gut Gram-positive bacteria, high gut permeability, Gram-positive bacteremia and NEC. Neonatal oral antibiotics may benefit mucosal and systemic immunity via delayed gut colonization and enhanced blood neutrophil maturation just after preterm birth. 2015-10-09 Article PeerReviewed text en http://ir.unimas.my/id/eprint/39027/1/Oral%20antibiotics%20increase%20blood%20neutrophil.pdf Duc Ninh, Nguyen and Eva, Fuglsang and Pingping, Jiang and Birck, Malene M. and Xiaoyu, Pan and Shamrulazhar, Shamzir Kamal and Pors, Susanne E and Gammelgaard, Pernille L and Nielsen, Dennis Sandris and Thymann, Thomas and Levy, Ofer and Frokier, Hanne and Sangild, Per Torp (2015) Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs. Innate Immunity, 22 (1). pp. 51-62. https://journals.sagepub.com/doi/10.1177/1753425915615195 10.1177/1753425915615195
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic QL Zoology
QP Physiology
QR Microbiology
S Agriculture (General)
SF Animal culture
spellingShingle QL Zoology
QP Physiology
QR Microbiology
S Agriculture (General)
SF Animal culture
Duc Ninh, Nguyen
Eva, Fuglsang
Pingping, Jiang
Birck, Malene M.
Xiaoyu, Pan
Shamrulazhar, Shamzir Kamal
Pors, Susanne E
Gammelgaard, Pernille L
Nielsen, Dennis Sandris
Thymann, Thomas
Levy, Ofer
Frokier, Hanne
Sangild, Per Torp
Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs
description Immature immunity may predispose preterm neonates to infections and necrotizing enterocolitis (NEC). Intravenous antibiotics are frequently given to prevent and treat sepsis, while oral antibiotics are seldom used. We hypothesized that oral antibiotics promote maturation of systemic immunity and delay gut bacterial colonization and thereby protect preterm neonates against both NEC and bacteremia in the immediate postnatal period. Preterm pigs were given formula and administered saline (CON) or broad-spectrum antibiotics orally (ORA) or systemically (SYS) for 5 d after birth. Temporal changes in blood parameters and bacterial composition in the intestine, blood and immune organs were analyzed. Newborn preterm pigs had few blood neutrophils and a high frequency of progenitor cells. Neutrophils gradually matured after preterm birth with increasing CD14 and decreasing CD172a expressions. Preterm neutrophil and monocyte TLR2 expression and TLR2-mediated blood cytokine responses were low relative to adults. ORA pigs showed enhanced blood neutrophil maturation with reduced cell size and CD172a expression. Only ORA pigs, but not SYS pigs, were protected from a high density of gut Gram-positive bacteria, high gut permeability, Gram-positive bacteremia and NEC. Neonatal oral antibiotics may benefit mucosal and systemic immunity via delayed gut colonization and enhanced blood neutrophil maturation just after preterm birth.
format Article
author Duc Ninh, Nguyen
Eva, Fuglsang
Pingping, Jiang
Birck, Malene M.
Xiaoyu, Pan
Shamrulazhar, Shamzir Kamal
Pors, Susanne E
Gammelgaard, Pernille L
Nielsen, Dennis Sandris
Thymann, Thomas
Levy, Ofer
Frokier, Hanne
Sangild, Per Torp
author_facet Duc Ninh, Nguyen
Eva, Fuglsang
Pingping, Jiang
Birck, Malene M.
Xiaoyu, Pan
Shamrulazhar, Shamzir Kamal
Pors, Susanne E
Gammelgaard, Pernille L
Nielsen, Dennis Sandris
Thymann, Thomas
Levy, Ofer
Frokier, Hanne
Sangild, Per Torp
author_sort Duc Ninh, Nguyen
title Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs
title_short Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs
title_full Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs
title_fullStr Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs
title_full_unstemmed Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs
title_sort oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs
publishDate 2015
url http://ir.unimas.my/id/eprint/39027/1/Oral%20antibiotics%20increase%20blood%20neutrophil.pdf
http://ir.unimas.my/id/eprint/39027/
https://journals.sagepub.com/doi/10.1177/1753425915615195
_version_ 1740829587670040576
score 13.211869

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