Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana
Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known terpenoids...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd
2016
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/38547/1/beccariana1.pdf http://ir.unimas.my/id/eprint/38547/ https://doi.org/10.1016/j.phytol.2016.07.026 |
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| Summary: | Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one
new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three
known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known
terpenoids, friedelin (6), stigmasterol (7), beta-sitosterol (8) and gamma-sitosterol (9). The structures of
these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS.
The cytotoxic activities of compounds 1-4 as well as the crude extracts were tested againsttwo cancer cell
lines, Hep G2 (liver cancer cell line) and HT-29 (colon cancer cell line) using MTTassays. Mesuarianone (3)
gave a significant activity on the HT-29 cell line while mesuasinone (4) gave moderate activity against HT29 cell line |
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