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Identification of Deregulated Imprinted Genes Involved in Colorectal Cancer

Colorectal cancer (CRC) is one of the serious threat in Malaysia and the involvement of the imprinted genes in CRC is not yet identified. Colorectal Cancer (CRC) is the third deadliest reported cancer in Malaysia for both sexes. Globally, CRC is the third common cancer in men and second in female. T...

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Main Author: Nik Mohamad Ameer, Nik Mohamad Nazirin
Format: Final Year Project Report
Language:English
Published: Universiti Malaysia Sarawak, (UNIMAS) 2018
Subjects:
Q Science (General)
Online Access:http://ir.unimas.my/id/eprint/36061/2/NIK%20MOHD%20AMEER%20%28ft%29.pdf
http://ir.unimas.my/id/eprint/36061/
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spelling my.unimas.ir.360612024-02-05T02:55:18Z http://ir.unimas.my/id/eprint/36061/ Identification of Deregulated Imprinted Genes Involved in Colorectal Cancer Nik Mohamad Ameer, Nik Mohamad Nazirin Q Science (General) Colorectal cancer (CRC) is one of the serious threat in Malaysia and the involvement of the imprinted genes in CRC is not yet identified. Colorectal Cancer (CRC) is the third deadliest reported cancer in Malaysia for both sexes. Globally, CRC is the third common cancer in men and second in female. The imprinted genes are the genes that monoallelically expressed whether from paternal or maternal. This phenomenon is not a pathology. In this study, meta-analysis and bioinformatics method is used in order to identify the deregulated imprinted genes that involved in the CRC. Loss of heterozygosity (LOH) data from twelve previously published data are analysed and the full LOH map for CRC for each chromosome is created. From the LOH map, the common deleted regions (CDR) for each chromosome is identified. The CDR is amalgamated with the imprintome dataset. Therefore, we identified imprinted genes NH2PL 1 and RHOBTB3 to be located at the CDR of CRC. Universiti Malaysia Sarawak, (UNIMAS) 2018 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/36061/2/NIK%20MOHD%20AMEER%20%28ft%29.pdf Nik Mohamad Ameer, Nik Mohamad Nazirin (2018) Identification of Deregulated Imprinted Genes Involved in Colorectal Cancer. [Final Year Project Report] (Unpublished)
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Nik Mohamad Ameer, Nik Mohamad Nazirin
Identification of Deregulated Imprinted Genes Involved in Colorectal Cancer
description Colorectal cancer (CRC) is one of the serious threat in Malaysia and the involvement of the imprinted genes in CRC is not yet identified. Colorectal Cancer (CRC) is the third deadliest reported cancer in Malaysia for both sexes. Globally, CRC is the third common cancer in men and second in female. The imprinted genes are the genes that monoallelically expressed whether from paternal or maternal. This phenomenon is not a pathology. In this study, meta-analysis and bioinformatics method is used in order to identify the deregulated imprinted genes that involved in the CRC. Loss of heterozygosity (LOH) data from twelve previously published data are analysed and the full LOH map for CRC for each chromosome is created. From the LOH map, the common deleted regions (CDR) for each chromosome is identified. The CDR is amalgamated with the imprintome dataset. Therefore, we identified imprinted genes NH2PL 1 and RHOBTB3 to be located at the CDR of CRC.
format Final Year Project Report
author Nik Mohamad Ameer, Nik Mohamad Nazirin
author_facet Nik Mohamad Ameer, Nik Mohamad Nazirin
author_sort Nik Mohamad Ameer, Nik Mohamad Nazirin
title Identification of Deregulated Imprinted Genes Involved in Colorectal Cancer
title_short Identification of Deregulated Imprinted Genes Involved in Colorectal Cancer
title_full Identification of Deregulated Imprinted Genes Involved in Colorectal Cancer
title_fullStr Identification of Deregulated Imprinted Genes Involved in Colorectal Cancer
title_full_unstemmed Identification of Deregulated Imprinted Genes Involved in Colorectal Cancer
title_sort identification of deregulated imprinted genes involved in colorectal cancer
publisher Universiti Malaysia Sarawak, (UNIMAS)
publishDate 2018
url http://ir.unimas.my/id/eprint/36061/2/NIK%20MOHD%20AMEER%20%28ft%29.pdf
http://ir.unimas.my/id/eprint/36061/
_version_ 1792160687555870720
score 13.211869

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