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Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia

Zoonotic cases of Plasmodium knowlesi account for most malaria cases in Malaysia, and humans infected with P. cynomolgi, another parasite of macaques have recently been reported in Sarawak. To date the epidemiology of malaria in its natural Macaca reservoir hosts remains little investigated. In this...

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Main Authors: Amirah, Amir, Shahhaziq, Shahari, Jonathan Wee Kent, Liew, Jeremy Ryan, de Silva, Mohammad Behram, Khan, Meng Yee, Lai, Georges, Snounou, Mohd Lutfi, Abdullah, Millawati, Gani, Jeffrine J., Rovie-Ryan, Yee-Ling, Lau
Format: Article
Language:English
Published: ELSEVIER 2020
Subjects:
QL Zoology
Online Access:http://ir.unimas.my/id/eprint/35946/1/plasmodium1.pdf
http://ir.unimas.my/id/eprint/35946/
https://www.sciencedirect.com/science/article/abs/pii/S0001706X20306033
https://doi.org/10.1016/j.actatropica.2020.105596
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spelling my.unimas.ir.359462021-09-01T03:22:19Z http://ir.unimas.my/id/eprint/35946/ Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia Amirah, Amir Shahhaziq, Shahari Jonathan Wee Kent, Liew Jeremy Ryan, de Silva Mohammad Behram, Khan Meng Yee, Lai Georges, Snounou Mohd Lutfi, Abdullah Millawati, Gani Jeffrine J., Rovie-Ryan Yee-Ling, Lau QL Zoology Zoonotic cases of Plasmodium knowlesi account for most malaria cases in Malaysia, and humans infected with P. cynomolgi, another parasite of macaques have recently been reported in Sarawak. To date the epidemiology of malaria in its natural Macaca reservoir hosts remains little investigated. In this study we surveyed the prevalence of simian malaria in wild macaques of three states in Peninsular Malaysia, namely Pahang, Perak and Johor using blood samples from 103 wild macaques (collected by the Department of Wildlife and National Parks Peninsular Malaysia) subjected to microscopic examination and nested PCR targeting the Plasmodium small subunit ribosomal RNA gene. As expected, PCR analysis yielded significantly higher prevalence (64/103) as compared to microscopic examination (27/103). No relationship between the age and/or sex of the macaques with the parasitaemia and the Plasmodium species infecting the macaques could be identified. Wild macaques in Pahang had the highest prevalence of Plasmodium parasites (89.7%), followed by those of Perak (69.2%) and Johor (28.9%). Plasmodium inui and P. cynomolgi were the two most prevalent species infecting the macaques from all three states. Half of the macaques (33/64) harboured two or more Plasmodium species. These data provide a baseline survey, which should be extended by further longitudinal investigations that should be associated with studies on the bionomics of the anopheline vectors. This information will allow an accurate evaluation of the risk of zoonotic transmission to humans, and to elaborate effective strategies to control simian malaria. ELSEVIER 2020-06-23 Article PeerReviewed text en http://ir.unimas.my/id/eprint/35946/1/plasmodium1.pdf Amirah, Amir and Shahhaziq, Shahari and Jonathan Wee Kent, Liew and Jeremy Ryan, de Silva and Mohammad Behram, Khan and Meng Yee, Lai and Georges, Snounou and Mohd Lutfi, Abdullah and Millawati, Gani and Jeffrine J., Rovie-Ryan and Yee-Ling, Lau (2020) Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia. Acta Tropica, 211 (2020). pp. 1-6. ISSN 0001-706X https://www.sciencedirect.com/science/article/abs/pii/S0001706X20306033 https://doi.org/10.1016/j.actatropica.2020.105596
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic QL Zoology
spellingShingle QL Zoology
Amirah, Amir
Shahhaziq, Shahari
Jonathan Wee Kent, Liew
Jeremy Ryan, de Silva
Mohammad Behram, Khan
Meng Yee, Lai
Georges, Snounou
Mohd Lutfi, Abdullah
Millawati, Gani
Jeffrine J., Rovie-Ryan
Yee-Ling, Lau
Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia
description Zoonotic cases of Plasmodium knowlesi account for most malaria cases in Malaysia, and humans infected with P. cynomolgi, another parasite of macaques have recently been reported in Sarawak. To date the epidemiology of malaria in its natural Macaca reservoir hosts remains little investigated. In this study we surveyed the prevalence of simian malaria in wild macaques of three states in Peninsular Malaysia, namely Pahang, Perak and Johor using blood samples from 103 wild macaques (collected by the Department of Wildlife and National Parks Peninsular Malaysia) subjected to microscopic examination and nested PCR targeting the Plasmodium small subunit ribosomal RNA gene. As expected, PCR analysis yielded significantly higher prevalence (64/103) as compared to microscopic examination (27/103). No relationship between the age and/or sex of the macaques with the parasitaemia and the Plasmodium species infecting the macaques could be identified. Wild macaques in Pahang had the highest prevalence of Plasmodium parasites (89.7%), followed by those of Perak (69.2%) and Johor (28.9%). Plasmodium inui and P. cynomolgi were the two most prevalent species infecting the macaques from all three states. Half of the macaques (33/64) harboured two or more Plasmodium species. These data provide a baseline survey, which should be extended by further longitudinal investigations that should be associated with studies on the bionomics of the anopheline vectors. This information will allow an accurate evaluation of the risk of zoonotic transmission to humans, and to elaborate effective strategies to control simian malaria.
format Article
author Amirah, Amir
Shahhaziq, Shahari
Jonathan Wee Kent, Liew
Jeremy Ryan, de Silva
Mohammad Behram, Khan
Meng Yee, Lai
Georges, Snounou
Mohd Lutfi, Abdullah
Millawati, Gani
Jeffrine J., Rovie-Ryan
Yee-Ling, Lau
author_facet Amirah, Amir
Shahhaziq, Shahari
Jonathan Wee Kent, Liew
Jeremy Ryan, de Silva
Mohammad Behram, Khan
Meng Yee, Lai
Georges, Snounou
Mohd Lutfi, Abdullah
Millawati, Gani
Jeffrine J., Rovie-Ryan
Yee-Ling, Lau
author_sort Amirah, Amir
title Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia
title_short Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia
title_full Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia
title_fullStr Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia
title_full_unstemmed Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia
title_sort natural plasmodium infection in wild macaques of three states in peninsular malaysia
publisher ELSEVIER
publishDate 2020
url http://ir.unimas.my/id/eprint/35946/1/plasmodium1.pdf
http://ir.unimas.my/id/eprint/35946/
https://www.sciencedirect.com/science/article/abs/pii/S0001706X20306033
https://doi.org/10.1016/j.actatropica.2020.105596
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score 13.211869

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