Drug Design : Pharmacophore Modelling and Synthesis of Benzaldehyde Derivatives As Flies Repellent
Housefly (Musca domestica L.) is known as a vector of diseases to human. It can spread the various bacteria to the human through contaminated water source, poultry, animals, contaminated food and so on. Common diseases that caused by Musca domestica are typhoid fever, cholera, diarrhoeal disease...
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| Main Author: | |
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| Format: | Final Year Project Report |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2014
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| Online Access: | http://ir.unimas.my/id/eprint/34073/1/Low%20Jiin%20Yeu%20ft.pdf http://ir.unimas.my/id/eprint/34073/ |
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| Summary: | Housefly (Musca domestica L.) is known as a vector of diseases to human. It can spread
the various bacteria to the human through contaminated water source, poultry, animals,
contaminated food and so on. Common diseases that caused by Musca domestica are
typhoid fever, cholera, diarrhoeal disease and others. Because of the houseflies resistant to
the insect repellents easily, thus it is necessary to synthesize new compound that can kill
Musca domestica. By using pharmacophore modelling approach, the new lead compound
can be discovered. The pharmacophore features include of hydrogen-bond acceptor (HBA),
hydrophobic group (HY) or aromatic ring (AR) features. The benzaldehyde derivatives
were synthesized via the Schiff base reaction. For the characterization of the synthesized
compounds, NMR and FTIR and CHN analysis were used. The cytotoxicity test using
brine shrimp, antioxidant activity test using DPPH and the biological repellent test using
life flies were the validation test for the synthesized compounds. In this research,
compound 3 and 13 are the best compounds as flies repellent based on the pharmacophore
modelling and biological activity. |
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