Inhibition of lysosomal vacuolar proton pump down-regulates cellular acidification and enhances E. coli bactofection efficiency
Endosomal escape is considered a crucial barrier that needs to be overcome by integrin-mediated E. coli for gene delivery into mammalian cells. Bafilomycin, a potent inhibitor of the H+ proton pump commonly employed to lower endosomal pH, was evaluated as part of the E. coli protocol during deliver...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/34011/1/Inhibition%20of%20lysosomal%20vacuolar%20proton%20pump%20down-regulates%20cellular%20acidification%20and%20enhances%20E.%20coli%20bactofection%20efficiency.pdf http://ir.unimas.my/id/eprint/34011/ https://www.journals.elsevier.com/analytical-biochemistry/ |
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