Staff View: Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia

Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia

Introduction Cervical cancer is common cancer and ranked in fourth place in both incidence and mortality worldwide. It is 3rd most common female cancer in Malaysia with a lifetime risk of 1 in 116. Infection with high-risk oncogenic human papillomavirus (HPV) is recognized as one of the substantia...

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Main Authors:	Myat, San Yi, Tan, Cheng Siang, Soe, Lwin, Khin, Than Yee, Kipli, Mardiana
Format:	Article
Language:	English
Published:	A and V Publication 2021
Subjects:	RG Gynecology and obstetrics
Online Access:	http://ir.unimas.my/id/eprint/32672/1/Prevalence%20of%20Human%20Papillomavirus%20in%20Women%20with%20Abnormal%20Cervical.pdf http://ir.unimas.my/id/eprint/32672/ https://rjptonline.org/
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spelling	my.unimas.ir.326722020-11-10T01:17:23Z http://ir.unimas.my/id/eprint/32672/ Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia Myat, San Yi Tan, Cheng Siang Soe, Lwin Khin, Than Yee Kipli, Mardiana RG Gynecology and obstetrics Introduction Cervical cancer is common cancer and ranked in fourth place in both incidence and mortality worldwide. It is 3rd most common female cancer in Malaysia with a lifetime risk of 1 in 116. Infection with high-risk oncogenic human papillomavirus (HPV) is recognized as one of the substantial risk factors for the development of cervical cancers. Methods It was a cross-sectional study conducted to determine the prevalence of HPV infection and its subtypes among women with various degrees of abnormal smears, who were seen in the colposcopy clinic of Sarawak General Hospital within six months’ period from January to June 2018. We recruited 56 participants. There were 23 each for an atypical squamous cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) and 10 high- grade squamous intraepithelial lesion (HSIL). DNA was extracted, and HPV genotypes were determined via polymerase chain reaction (PCR) using two primer pairs MY09/MY11 and GP5+/GP6+. Results The age ranged from 23 to 56 years, with a mean age of 42.96 years. HPV was detected in 20 out of 56 (35.7%). There were 6 high-risk oncogenic HPVs (18, 51, 52, 56, 58, 68) detected in participants and the most prevalent subtypes were 18, 52, and 58 (20% each). Four low-risk HPVs detected were 6, 53, 70, and 84. There was a significant association between the severity of cervical lesions and HPV positivity (P < 0.004). HSIL had the highest positive predictive value to have HPV infection as 70% compared to 43.4% of LSIL and 9.3% of ASC-US. Conclusion Distribution of HPV subtypes from women with abnormal smears from Sarawak indicated a high prevalence of HPV 18, 52, and 58. We also identified HPV 70, which has never been reported in West Malaysia. These findings could contribute valuable information for HPV vaccination strategies, particularly for Sarawakian women. A and V Publication 2021-05 Article PeerReviewed text en http://ir.unimas.my/id/eprint/32672/1/Prevalence%20of%20Human%20Papillomavirus%20in%20Women%20with%20Abnormal%20Cervical.pdf Myat, San Yi and Tan, Cheng Siang and Soe, Lwin and Khin, Than Yee and Kipli, Mardiana (2021) Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia. Research Journal of Pharmacy and Technology, 14 (05). ISSN 0974-360X https://rjptonline.org/ DOI: 10.5958/0974-360X
institution	Universiti Malaysia Sarawak
building	Centre for Academic Information Services (CAIS)
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sarawak
content_source	UNIMAS Institutional Repository
url_provider	http://ir.unimas.my/
language	English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Myat, San Yi Tan, Cheng Siang Soe, Lwin Khin, Than Yee Kipli, Mardiana Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia
description	Introduction Cervical cancer is common cancer and ranked in fourth place in both incidence and mortality worldwide. It is 3rd most common female cancer in Malaysia with a lifetime risk of 1 in 116. Infection with high-risk oncogenic human papillomavirus (HPV) is recognized as one of the substantial risk factors for the development of cervical cancers. Methods It was a cross-sectional study conducted to determine the prevalence of HPV infection and its subtypes among women with various degrees of abnormal smears, who were seen in the colposcopy clinic of Sarawak General Hospital within six months’ period from January to June 2018. We recruited 56 participants. There were 23 each for an atypical squamous cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) and 10 high- grade squamous intraepithelial lesion (HSIL). DNA was extracted, and HPV genotypes were determined via polymerase chain reaction (PCR) using two primer pairs MY09/MY11 and GP5+/GP6+. Results The age ranged from 23 to 56 years, with a mean age of 42.96 years. HPV was detected in 20 out of 56 (35.7%). There were 6 high-risk oncogenic HPVs (18, 51, 52, 56, 58, 68) detected in participants and the most prevalent subtypes were 18, 52, and 58 (20% each). Four low-risk HPVs detected were 6, 53, 70, and 84. There was a significant association between the severity of cervical lesions and HPV positivity (P < 0.004). HSIL had the highest positive predictive value to have HPV infection as 70% compared to 43.4% of LSIL and 9.3% of ASC-US. Conclusion Distribution of HPV subtypes from women with abnormal smears from Sarawak indicated a high prevalence of HPV 18, 52, and 58. We also identified HPV 70, which has never been reported in West Malaysia. These findings could contribute valuable information for HPV vaccination strategies, particularly for Sarawakian women.
format	Article
author	Myat, San Yi Tan, Cheng Siang Soe, Lwin Khin, Than Yee Kipli, Mardiana
author_facet	Myat, San Yi Tan, Cheng Siang Soe, Lwin Khin, Than Yee Kipli, Mardiana
author_sort	Myat, San Yi
title	Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia
title_short	Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia
title_full	Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia
title_fullStr	Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia
title_full_unstemmed	Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia
title_sort	prevalence of human papillomavirus in women with abnormal cervical smears from sarawak, malaysia
publisher	A and V Publication
publishDate	2021
url	http://ir.unimas.my/id/eprint/32672/1/Prevalence%20of%20Human%20Papillomavirus%20in%20Women%20with%20Abnormal%20Cervical.pdf http://ir.unimas.my/id/eprint/32672/ https://rjptonline.org/
_version_	1684657055123636224
score	13.211869

Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia

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