Cover Image

Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients

The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI...

Full description

Saved in:
Bibliographic Details
Main Authors: Nurul Hanim, Nasaruddin, Ahmad Nazlim, Yusoff, Sharanjeet, Kaur
Format: Article
Language:English
Published: Fakulti Sains Kesihatan (Faculty of Health Sciences) and Penerbit UKM (UKM Press) 2017
Subjects:
H Social Sciences (General)
Q Science (General)
Online Access:http://ir.unimas.my/id/eprint/32393/3/Functional%20MRI.pdf
http://ir.unimas.my/id/eprint/32393/
https://publons.com/journal/53184/jurnal-sains-kesihatan-malaysia/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.unimas.ir.32393
record_format eprints
spelling my.unimas.ir.323932022-06-23T01:53:13Z http://ir.unimas.my/id/eprint/32393/ Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients Nurul Hanim, Nasaruddin Ahmad Nazlim, Yusoff Sharanjeet, Kaur H Social Sciences (General) Q Science (General) The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI) respectively. The fMRI scans and SAP test were both carried out in Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Two types of black-and-white checkerboard pattern were displayed to the participants during the fMRI scans. The fMRI data were analyzed using WFU pickatlas toolbox targeting visual cortex area. The results showed that there was no significant difference in number of activated voxel between the three groups in visual cortex (BA 17, 18 and 19) while viewing all the given stimuli (p > 0.05). The pattern standard deviation (PSD) of SAP for visual field also revealed no significant differences (p > 0.05) in all groups of participants. However, negative correlation between PSD and fMRI activation was observed. The PSD values increased with a decrease in fMRI activation. With reference to visual field analysis, the results suggest that glaucomatous neuropathy of POAG patients has led to a gradual decrease in visual cortex activation and a gradual increase in PSD Fakulti Sains Kesihatan (Faculty of Health Sciences) and Penerbit UKM (UKM Press) 2017 Article PeerReviewed text en http://ir.unimas.my/id/eprint/32393/3/Functional%20MRI.pdf Nurul Hanim, Nasaruddin and Ahmad Nazlim, Yusoff and Sharanjeet, Kaur (2017) Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients. Jurnal Sains Kesihatan Malaysia, 15 (1). pp. 27-32. ISSN 2289-4535 https://publons.com/journal/53184/jurnal-sains-kesihatan-malaysia/ DOI : http://dx.doi.org./10.17576/JSKM-2017-1501-04
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic H Social Sciences (General)
Q Science (General)
spellingShingle H Social Sciences (General)
Q Science (General)
Nurul Hanim, Nasaruddin
Ahmad Nazlim, Yusoff
Sharanjeet, Kaur
Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients
description The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI) respectively. The fMRI scans and SAP test were both carried out in Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Two types of black-and-white checkerboard pattern were displayed to the participants during the fMRI scans. The fMRI data were analyzed using WFU pickatlas toolbox targeting visual cortex area. The results showed that there was no significant difference in number of activated voxel between the three groups in visual cortex (BA 17, 18 and 19) while viewing all the given stimuli (p > 0.05). The pattern standard deviation (PSD) of SAP for visual field also revealed no significant differences (p > 0.05) in all groups of participants. However, negative correlation between PSD and fMRI activation was observed. The PSD values increased with a decrease in fMRI activation. With reference to visual field analysis, the results suggest that glaucomatous neuropathy of POAG patients has led to a gradual decrease in visual cortex activation and a gradual increase in PSD
format Article
author Nurul Hanim, Nasaruddin
Ahmad Nazlim, Yusoff
Sharanjeet, Kaur
author_facet Nurul Hanim, Nasaruddin
Ahmad Nazlim, Yusoff
Sharanjeet, Kaur
author_sort Nurul Hanim, Nasaruddin
title Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients
title_short Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients
title_full Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients
title_fullStr Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients
title_full_unstemmed Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients
title_sort functional mri characteristics in visual cortex (ba 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (gs) and primary open angle glaucoma (poag) patients
publisher Fakulti Sains Kesihatan (Faculty of Health Sciences) and Penerbit UKM (UKM Press)
publishDate 2017
url http://ir.unimas.my/id/eprint/32393/3/Functional%20MRI.pdf
http://ir.unimas.my/id/eprint/32393/
https://publons.com/journal/53184/jurnal-sains-kesihatan-malaysia/
_version_ 1736838285521584128
score 13.211869

Similar Items