Staff View: The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers

The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers

Cigarette smoking is a pervasive high-risk behavior and recent studies reported that nicotine in tobacco influences a wide variety of cognitive domains. BDNF is one of the factors of the neurotrophin family that can regulate the cognitive functions of the brain. The purpose of this study is to asses...

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Main Authors:	Han, Myitzu, Thwin, Mya Mya, Aung, Cho Lwin, Yi, Myat San, Yee, Khin Than, Mohd Nasir, Mat Nor, Bhagat, Vidya
Format:	Article
Published:	RJPT 2020
Subjects:	R Medicine (General)
Online Access:	http://ir.unimas.my/id/eprint/32194/ https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2020-13-10-68
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spelling	my.unimas.ir.321942020-10-16T01:22:16Z http://ir.unimas.my/id/eprint/32194/ The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers Han, Myitzu Thwin, Mya Mya Aung, Cho Lwin Yi, Myat San Yee, Khin Than Mohd Nasir, Mat Nor Bhagat, Vidya R Medicine (General) Cigarette smoking is a pervasive high-risk behavior and recent studies reported that nicotine in tobacco influences a wide variety of cognitive domains. BDNF is one of the factors of the neurotrophin family that can regulate the cognitive functions of the brain. The purpose of this study is to assess the relationship between serum BDNF level and cognitive function in middle-aged (40-60years) male chronic smokers. The material used in the study, Brain-derived neurotrophic factor (BDNF) and General Memory Scale (GMS) to assay ELISA, and to test the cognitive function respectively. The results showed that serum BDNF level of chronic smokers (19.19±6.05ng/ml) was comparable with that of non-smokers (20.83±8.63ng/ml). The total GMS scores of chronic smokers (n=41) had significantly lowered total GMS scores (56.88±12.24) than that of non-smokers (n=41) (67.74±7.59) demonstrated cognitive functions. Although the cognitive function of chronic smokers was significantly lower than that of non-smokers, serum BDNF level of chronic smokers was not significantly different from non-smokers (p>0.05). Moreover, serum BDNF level was positively correlated with cognitive function (total GMS scores) in both chronic smokers’ group (r =0.453, p=0.003) and non-smokers group (r =0.458, p=0.003). The study results indicate, even in middle-age healthy adults, chronic smoking would impair cognitive function. The study concludes by portending the role of BDNF in cognitive function, whether or not the individuals are chronic smokers. RJPT 2020 Article PeerReviewed Han, Myitzu and Thwin, Mya Mya and Aung, Cho Lwin and Yi, Myat San and Yee, Khin Than and Mohd Nasir, Mat Nor and Bhagat, Vidya (2020) The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers. Research Journal of Pharmacy and Technology, 13 (10). pp. 4925-4930. ISSN 0974-360X https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2020-13-10-68 10.5958/0974-360X.2020.00865.3
institution	Universiti Malaysia Sarawak
building	Centre for Academic Information Services (CAIS)
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sarawak
content_source	UNIMAS Institutional Repository
url_provider	http://ir.unimas.my/
topic	R Medicine (General)
spellingShingle	R Medicine (General) Han, Myitzu Thwin, Mya Mya Aung, Cho Lwin Yi, Myat San Yee, Khin Than Mohd Nasir, Mat Nor Bhagat, Vidya The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers
description	Cigarette smoking is a pervasive high-risk behavior and recent studies reported that nicotine in tobacco influences a wide variety of cognitive domains. BDNF is one of the factors of the neurotrophin family that can regulate the cognitive functions of the brain. The purpose of this study is to assess the relationship between serum BDNF level and cognitive function in middle-aged (40-60years) male chronic smokers. The material used in the study, Brain-derived neurotrophic factor (BDNF) and General Memory Scale (GMS) to assay ELISA, and to test the cognitive function respectively. The results showed that serum BDNF level of chronic smokers (19.19±6.05ng/ml) was comparable with that of non-smokers (20.83±8.63ng/ml). The total GMS scores of chronic smokers (n=41) had significantly lowered total GMS scores (56.88±12.24) than that of non-smokers (n=41) (67.74±7.59) demonstrated cognitive functions. Although the cognitive function of chronic smokers was significantly lower than that of non-smokers, serum BDNF level of chronic smokers was not significantly different from non-smokers (p>0.05). Moreover, serum BDNF level was positively correlated with cognitive function (total GMS scores) in both chronic smokers’ group (r =0.453, p=0.003) and non-smokers group (r =0.458, p=0.003). The study results indicate, even in middle-age healthy adults, chronic smoking would impair cognitive function. The study concludes by portending the role of BDNF in cognitive function, whether or not the individuals are chronic smokers.
format	Article
author	Han, Myitzu Thwin, Mya Mya Aung, Cho Lwin Yi, Myat San Yee, Khin Than Mohd Nasir, Mat Nor Bhagat, Vidya
author_facet	Han, Myitzu Thwin, Mya Mya Aung, Cho Lwin Yi, Myat San Yee, Khin Than Mohd Nasir, Mat Nor Bhagat, Vidya
author_sort	Han, Myitzu
title	The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers
title_short	The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers
title_full	The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers
title_fullStr	The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers
title_full_unstemmed	The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers
title_sort	relationship between serum brain - derived neurotrophic factor (bdnf) level and cognitive function in middle aged male chronic smokers
publisher	RJPT
publishDate	2020
url	http://ir.unimas.my/id/eprint/32194/ https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2020-13-10-68
_version_	1681492677974032384
score	13.211869

The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers

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