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XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians

AIM: To investigate the risk association of xeroderma pigmentosum group C (XPC ) Lys939Gln polymorphism alone and in combination with cigarette smoking on colorectal cancer (CRC) predisposition. METHODS: Peripheral blood samples of 510 study subjects (255 CRC patients, 255 controls)were collect...

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Main Authors: Ahmad Aizat, Abdul Aziz, Siti Nurfatimah, Mohd Shahpudin, Mohd Aminudin, Mustapha, Ravindran, Ankathil
Format: E-Article
Language:English
Published: Baishideng 2013
Subjects:
Q Science (General)
R Medicine (General)
Online Access:http://ir.unimas.my/id/eprint/30235/1/XPC%20Lys939Gln.pdf
http://ir.unimas.my/id/eprint/30235/
https://www.researchgate.net/publication/242017796_XPC_Lys939Gln_polymorphism_smoking_and_risk_of_sporadic_colorectal_cancer_among_Malaysians
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spelling my.unimas.ir.302352020-07-07T08:15:45Z http://ir.unimas.my/id/eprint/30235/ XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians Ahmad Aizat, Abdul Aziz Siti Nurfatimah, Mohd Shahpudin Mohd Aminudin, Mustapha Ravindran, Ankathil Q Science (General) R Medicine (General) AIM: To investigate the risk association of xeroderma pigmentosum group C (XPC ) Lys939Gln polymorphism alone and in combination with cigarette smoking on colorectal cancer (CRC) predisposition. METHODS: Peripheral blood samples of 510 study subjects (255 CRC patients, 255 controls)were collected. DNA was extracted and genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. The association between polymorphic genotype and CRC predisposition was determined using the OR and 95%CI. RESULTS: The frequency of the homozygous variant (Gln/Gln) genotype was significantly higher in cases compared with controls (16.0% vs 10.2%, P = 0.049). The Gln/Gln genotype of XPC showed a significantly higher association with the risk of CRC (OR = 1.884; 95%CI: 1.082-3.277; P = 0.025). In the case of allele frequencies, variant allele C was associated with a significantly increased risk of CRC (OR = 1.375; 95%CI: 1.050-1.802; P = 0.020). Moreover, the risk was markedly higher for those who were carriers of the Gln/Gln variant genotype and were also cigarette smokers (OR = 3.409; 95%CI: 1.061-10.949; P = 0.032). CONCLUSION: The XPC Gln/Gln genotype alone and in combination with smoking increases the risk of CRC among Malaysians. Baishideng 2013-06-21 E-Article PeerReviewed text en http://ir.unimas.my/id/eprint/30235/1/XPC%20Lys939Gln.pdf Ahmad Aizat, Abdul Aziz and Siti Nurfatimah, Mohd Shahpudin and Mohd Aminudin, Mustapha and Ravindran, Ankathil (2013) XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians. World Journal of Gastroenterology, 19 (23). pp. 3623-3628. ISSN 1007-9327 https://www.researchgate.net/publication/242017796_XPC_Lys939Gln_polymorphism_smoking_and_risk_of_sporadic_colorectal_cancer_among_Malaysians 10.3748/wjg.v19.i23.3623
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
R Medicine (General)
spellingShingle Q Science (General)
R Medicine (General)
Ahmad Aizat, Abdul Aziz
Siti Nurfatimah, Mohd Shahpudin
Mohd Aminudin, Mustapha
Ravindran, Ankathil
XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians
description AIM: To investigate the risk association of xeroderma pigmentosum group C (XPC ) Lys939Gln polymorphism alone and in combination with cigarette smoking on colorectal cancer (CRC) predisposition. METHODS: Peripheral blood samples of 510 study subjects (255 CRC patients, 255 controls)were collected. DNA was extracted and genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. The association between polymorphic genotype and CRC predisposition was determined using the OR and 95%CI. RESULTS: The frequency of the homozygous variant (Gln/Gln) genotype was significantly higher in cases compared with controls (16.0% vs 10.2%, P = 0.049). The Gln/Gln genotype of XPC showed a significantly higher association with the risk of CRC (OR = 1.884; 95%CI: 1.082-3.277; P = 0.025). In the case of allele frequencies, variant allele C was associated with a significantly increased risk of CRC (OR = 1.375; 95%CI: 1.050-1.802; P = 0.020). Moreover, the risk was markedly higher for those who were carriers of the Gln/Gln variant genotype and were also cigarette smokers (OR = 3.409; 95%CI: 1.061-10.949; P = 0.032). CONCLUSION: The XPC Gln/Gln genotype alone and in combination with smoking increases the risk of CRC among Malaysians.
format E-Article
author Ahmad Aizat, Abdul Aziz
Siti Nurfatimah, Mohd Shahpudin
Mohd Aminudin, Mustapha
Ravindran, Ankathil
author_facet Ahmad Aizat, Abdul Aziz
Siti Nurfatimah, Mohd Shahpudin
Mohd Aminudin, Mustapha
Ravindran, Ankathil
author_sort Ahmad Aizat, Abdul Aziz
title XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians
title_short XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians
title_full XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians
title_fullStr XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians
title_full_unstemmed XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians
title_sort xpc lys939gln polymorphism, smoking and risk of sporadic colorectal cancer among malaysians
publisher Baishideng
publishDate 2013
url http://ir.unimas.my/id/eprint/30235/1/XPC%20Lys939Gln.pdf
http://ir.unimas.my/id/eprint/30235/
https://www.researchgate.net/publication/242017796_XPC_Lys939Gln_polymorphism_smoking_and_risk_of_sporadic_colorectal_cancer_among_Malaysians
_version_ 1672614430531125248
score 13.211869

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