Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl) prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues
A series of (E)-3-(4-alkyloxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (2a-c) and (E)-3-(4- alkyloxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (3a-c) have been synthesized via Claisen-Schmidt condensation. The compounds differ in the length of alkyl groups, CnH2n+1, where n= 10, 12 and 14. The s...
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2009
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my.unimas.ir.297322021-04-24T21:59:31Z http://ir.unimas.my/id/eprint/29732/ Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl) prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues Zainab, Binti Ngaini Hasnain, Bin Hussain Kamarulzaman, Bin Kamaruddin Siti Muhaini, Binti Haris Fadzillah Q Science (General) QD Chemistry A series of (E)-3-(4-alkyloxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (2a-c) and (E)-3-(4- alkyloxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (3a-c) have been synthesized via Claisen-Schmidt condensation. The compounds differ in the length of alkyl groups, CnH2n+1, where n= 10, 12 and 14. The structures of the synthesized compounds were defined by elemental analysis, IR, H and C NMR. 1 13 Antimicrobial studies were carried out against E. coli ATCC 8739 to evaluate the effect of the hydroxyl and alkyl groups of the synthesised chalcones. All the synthesized compounds have shown significant antimicrobial activities. Chalcones (2a-c) showed better antimicrobial activities compared to chalcones (3a-c) respectively, with (E)-3-(4-decyloxyphenyl)-1-(2-hydroxyphenyl) prop-2-en-1-one showed the highest antimicrobial activity among the compounds tested. IDOSI Publications 2009 Article PeerReviewed text en http://ir.unimas.my/id/eprint/29732/1/zainab6.pdf Zainab, Binti Ngaini and Hasnain, Bin Hussain and Kamarulzaman, Bin Kamaruddin and Siti Muhaini, Binti Haris Fadzillah (2009) Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl) prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues. World Journal of Chemistry, 4 (1). pp. 9-14. ISSN 1817-3128 https://www.idosi.org/wjc/wjc.htm |
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Q Science (General) QD Chemistry Zainab, Binti Ngaini Hasnain, Bin Hussain Kamarulzaman, Bin Kamaruddin Siti Muhaini, Binti Haris Fadzillah Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl) prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues |
| description |
A series of (E)-3-(4-alkyloxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (2a-c) and (E)-3-(4-
alkyloxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (3a-c) have been synthesized via Claisen-Schmidt
condensation. The compounds differ in the length of alkyl groups, CnH2n+1, where n= 10, 12 and 14. The
structures of the synthesized compounds were defined by elemental analysis, IR, H and C NMR. 1 13 Antimicrobial studies were carried out against E. coli ATCC 8739 to evaluate the effect of the hydroxyl and alkyl
groups of the synthesised chalcones. All the synthesized compounds have shown significant antimicrobial
activities. Chalcones (2a-c) showed better antimicrobial activities compared to chalcones (3a-c) respectively,
with (E)-3-(4-decyloxyphenyl)-1-(2-hydroxyphenyl) prop-2-en-1-one showed the highest antimicrobial activity
among the compounds tested. |
| format |
Article |
| author |
Zainab, Binti Ngaini Hasnain, Bin Hussain Kamarulzaman, Bin Kamaruddin Siti Muhaini, Binti Haris Fadzillah |
| author_facet |
Zainab, Binti Ngaini Hasnain, Bin Hussain Kamarulzaman, Bin Kamaruddin Siti Muhaini, Binti Haris Fadzillah |
| author_sort |
Zainab, Binti Ngaini |
| title |
Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl)
prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues |
| title_short |
Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl)
prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues |
| title_full |
Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl)
prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues |
| title_fullStr |
Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl)
prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues |
| title_full_unstemmed |
Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl)
prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues |
| title_sort |
synthesis and antimicrobial studies of (e)-3-(4-alkyloxyphenyl)-1-(2-hydroxyphenyl)
prop-2-en-1-one, (e)-3-(4-alkyloxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one and their analogues |
| publisher |
IDOSI Publications |
| publishDate |
2009 |
| url |
http://ir.unimas.my/id/eprint/29732/1/zainab6.pdf http://ir.unimas.my/id/eprint/29732/ https://www.idosi.org/wjc/wjc.htm |
| _version_ |
1698700821704736768 |
| score |
13.211869 |