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Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis

Objectives The conclusive prognostic significance of cyclo-oxygenase-2 has been determined in various cancers but not in nasopharyngeal carcinoma. Therefore, this study aimed to evaluate the relationship of cyclo-oxygenase-2 expression with the survival outcome and treatment response of nasopharyng...

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Main Authors: Sim, Chor Chien, Sim, Edmund Ui Hang
Format: Article
Language:English
Published: Cambridge University Press 2020
Subjects:
R Medicine (General)
RF Otorhinolaryngology
Online Access:http://ir.unimas.my/id/eprint/29519/1/Over-expression.pdf
http://ir.unimas.my/id/eprint/29519/
https://www.cambridge.org/core/journals/journal-of-laryngology-and-otology/article/overexpression-of-cyclooxygenase2-predicts-poor-survival-of-patients-with-nasopharyngeal-carcinoma-a-metaanalysis/3DBBF587F53BFACBF13CD39FDF6E5603
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spelling my.unimas.ir.295192021-05-27T10:46:18Z http://ir.unimas.my/id/eprint/29519/ Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis Sim, Chor Chien Sim, Edmund Ui Hang R Medicine (General) RF Otorhinolaryngology Objectives The conclusive prognostic significance of cyclo-oxygenase-2 has been determined in various cancers but not in nasopharyngeal carcinoma. Therefore, this study aimed to evaluate the relationship of cyclo-oxygenase-2 expression with the survival outcome and treatment response of nasopharyngeal carcinoma patients via a systematic meta-analysis approach. Methods A meta-analysis was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (‘PRISMA’) checklist. The primary clinical characteristics of patients, and hazard ratios with 95 per cent confidence intervals of overall survival data, were tabulated from eligible studies. The relationship of cyclo-oxygenase-2 expression with survival outcome (expressed as hazard ratio) and treatment response (expressed as odds ratio) in nasopharyngeal carcinoma patients was analysed, and explained with the aid of forest plot charts. Results and conclusion The pooled hazard ratio for overall survival was 2.02 (95 per cent confidence interval = 1.65–2.47). This indicates that the over-expression of cyclo-oxygenase-2 is significantly associated with the poor survival of nasopharyngeal carcinoma patients. The pooled odds ratio of 0.98 (95 per cent confidence interval = 0.27–3.49) reveals that over-expression of cyclo-oxygenase-2 was not significantly related to the treatment outcome. Cambridge University Press 2020-03-16 Article PeerReviewed text en http://ir.unimas.my/id/eprint/29519/1/Over-expression.pdf Sim, Chor Chien and Sim, Edmund Ui Hang (2020) Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis. Journal of Laryngology and Otology, 134 (4). pp. 338-343. ISSN 1748-5460 https://www.cambridge.org/core/journals/journal-of-laryngology-and-otology/article/overexpression-of-cyclooxygenase2-predicts-poor-survival-of-patients-with-nasopharyngeal-carcinoma-a-metaanalysis/3DBBF587F53BFACBF13CD39FDF6E5603 DOI: 10.1017/S0022215120000614
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic R Medicine (General)
RF Otorhinolaryngology
spellingShingle R Medicine (General)
RF Otorhinolaryngology
Sim, Chor Chien
Sim, Edmund Ui Hang
Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis
description Objectives The conclusive prognostic significance of cyclo-oxygenase-2 has been determined in various cancers but not in nasopharyngeal carcinoma. Therefore, this study aimed to evaluate the relationship of cyclo-oxygenase-2 expression with the survival outcome and treatment response of nasopharyngeal carcinoma patients via a systematic meta-analysis approach. Methods A meta-analysis was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (‘PRISMA’) checklist. The primary clinical characteristics of patients, and hazard ratios with 95 per cent confidence intervals of overall survival data, were tabulated from eligible studies. The relationship of cyclo-oxygenase-2 expression with survival outcome (expressed as hazard ratio) and treatment response (expressed as odds ratio) in nasopharyngeal carcinoma patients was analysed, and explained with the aid of forest plot charts. Results and conclusion The pooled hazard ratio for overall survival was 2.02 (95 per cent confidence interval = 1.65–2.47). This indicates that the over-expression of cyclo-oxygenase-2 is significantly associated with the poor survival of nasopharyngeal carcinoma patients. The pooled odds ratio of 0.98 (95 per cent confidence interval = 0.27–3.49) reveals that over-expression of cyclo-oxygenase-2 was not significantly related to the treatment outcome.
format Article
author Sim, Chor Chien
Sim, Edmund Ui Hang
author_facet Sim, Chor Chien
Sim, Edmund Ui Hang
author_sort Sim, Chor Chien
title Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis
title_short Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis
title_full Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis
title_fullStr Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis
title_full_unstemmed Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis
title_sort over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis
publisher Cambridge University Press
publishDate 2020
url http://ir.unimas.my/id/eprint/29519/1/Over-expression.pdf
http://ir.unimas.my/id/eprint/29519/
https://www.cambridge.org/core/journals/journal-of-laryngology-and-otology/article/overexpression-of-cyclooxygenase2-predicts-poor-survival-of-patients-with-nasopharyngeal-carcinoma-a-metaanalysis/3DBBF587F53BFACBF13CD39FDF6E5603
_version_ 1701166529306951680
score 13.211869

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