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Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene

The treatment of chronic myeloid leukaemia (CML) requires quantitative polymerase chain reaction (qPCR) to monitor BCR-ABL1 in International Scale (IS). Some normal subjects were found to harbour BCR-ABL1. We performed a systematic review on normal subjects harbouring BCR-ABL1. A literature search w...

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Main Authors: Kuan, Jew-Win, Anselm, Su Ting, Leong, Chooi Fun, Osato, Motomi, Sashida, Goro
Format: Article
Language:English
Published: S. Karger AG 2019
Subjects:
QR Microbiology
RA0421 Public health. Hygiene. Preventive Medicine
Online Access:http://ir.unimas.my/id/eprint/28475/1/Jew-Win.pdf
http://ir.unimas.my/id/eprint/28475/
https://www.karger.com/Journal/Home/223829
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spelling my.unimas.ir.284752021-03-31T01:19:53Z http://ir.unimas.my/id/eprint/28475/ Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene Kuan, Jew-Win Anselm, Su Ting Leong, Chooi Fun Osato, Motomi Sashida, Goro QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine The treatment of chronic myeloid leukaemia (CML) requires quantitative polymerase chain reaction (qPCR) to monitor BCR-ABL1 in International Scale (IS). Some normal subjects were found to harbour BCR-ABL1. We performed a systematic review on normal subjects harbouring BCR-ABL1. A literature search was done on July 16, 2017 using EBSCOhost Research Databases interface and Western Pacific Region Index Medicus. Two authors selected the studies, extracted the data, and evaluated the quality of studies using the modified Appraisal Tool for Cross-Sectional Studies independently. The outcomes were prevalence, level of BCR-ABL1IS, proportion, and time of progression to CML. The initial search returned 4,770 studies. Eleven studies, all having used convenient sampling, were included, with total of 1,360 subjects. Ten studies used qualitative PCR and one used qPCR (not IS). The mean prevalence of M-BCR was 5.9, 15.5, and 15.9% in cord blood/newborns/infants (CB/NB/I) (n = 170), children (n = 90), and adults (n = 454), respectively, while m-BCR was 15, 26.9, and 23.1% in CB/NB/I (n = 786), children (n = 67), and adults (n = 208), respectively. No study reported the proportion and time of progression to CML. Nine studies were graded as moderate quality, one study as poor quality, and one study as unacceptable. The result of the studies could neither be inferred to the general normal population nor compared. Follow-up data were scarce S. Karger AG 2019 Article PeerReviewed text en http://ir.unimas.my/id/eprint/28475/1/Jew-Win.pdf Kuan, Jew-Win and Anselm, Su Ting and Leong, Chooi Fun and Osato, Motomi and Sashida, Goro (2019) Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene. Acta Haematologica, 142. pp. 1-16. ISSN 1421-9662 https://www.karger.com/Journal/Home/223829 DOI: 10.1159/000501146
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic QR Microbiology
RA0421 Public health. Hygiene. Preventive Medicine
spellingShingle QR Microbiology
RA0421 Public health. Hygiene. Preventive Medicine
Kuan, Jew-Win
Anselm, Su Ting
Leong, Chooi Fun
Osato, Motomi
Sashida, Goro
Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene
description The treatment of chronic myeloid leukaemia (CML) requires quantitative polymerase chain reaction (qPCR) to monitor BCR-ABL1 in International Scale (IS). Some normal subjects were found to harbour BCR-ABL1. We performed a systematic review on normal subjects harbouring BCR-ABL1. A literature search was done on July 16, 2017 using EBSCOhost Research Databases interface and Western Pacific Region Index Medicus. Two authors selected the studies, extracted the data, and evaluated the quality of studies using the modified Appraisal Tool for Cross-Sectional Studies independently. The outcomes were prevalence, level of BCR-ABL1IS, proportion, and time of progression to CML. The initial search returned 4,770 studies. Eleven studies, all having used convenient sampling, were included, with total of 1,360 subjects. Ten studies used qualitative PCR and one used qPCR (not IS). The mean prevalence of M-BCR was 5.9, 15.5, and 15.9% in cord blood/newborns/infants (CB/NB/I) (n = 170), children (n = 90), and adults (n = 454), respectively, while m-BCR was 15, 26.9, and 23.1% in CB/NB/I (n = 786), children (n = 67), and adults (n = 208), respectively. No study reported the proportion and time of progression to CML. Nine studies were graded as moderate quality, one study as poor quality, and one study as unacceptable. The result of the studies could neither be inferred to the general normal population nor compared. Follow-up data were scarce
format Article
author Kuan, Jew-Win
Anselm, Su Ting
Leong, Chooi Fun
Osato, Motomi
Sashida, Goro
author_facet Kuan, Jew-Win
Anselm, Su Ting
Leong, Chooi Fun
Osato, Motomi
Sashida, Goro
author_sort Kuan, Jew-Win
title Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene
title_short Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene
title_full Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene
title_fullStr Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene
title_full_unstemmed Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene
title_sort systematic review of normal subjects harbouring bcr-abl1 fusion gene
publisher S. Karger AG
publishDate 2019
url http://ir.unimas.my/id/eprint/28475/1/Jew-Win.pdf
http://ir.unimas.my/id/eprint/28475/
https://www.karger.com/Journal/Home/223829
_version_ 1696979501108428800
score 13.211869

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