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Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy

Adjuvant chemotherapy has long been indicated to extend survival in completely resected stage IB to IIIA non-small cell lung cancer (NSCLC). However, there is accumulating evidence that chemotherapy or chemoradiotherapy can induce epithelial-to-mesenchymal transition (EMT) in disseminated or circula...

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Main Authors: Chai, Chee-Shee, Poh, Mau Ern, Liam, Chong Kin, Mun, Kein Seong, Wong, Chee Kuan, Tan, Jiunn Liang, Loh, Thian Chee, Chin, Ka Kiat
Format: E-Article
Language:English
Published: China Lung Oncology Group and John Wiley & Sons Australia, Ltd 2019
Subjects:
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:http://ir.unimas.my/id/eprint/26259/1/Epithelial-to-mesenchymal%20transition%20%28EMT%29%20to%20sarcoma%20in%20recurrent%20lung%20adenosquamous%20-%20Copy.pdf
http://ir.unimas.my/id/eprint/26259/
https://onlinelibrary.wiley.com/doi/full/10.1111/1759-7714.13156
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spelling my.unimas.ir.262592020-06-24T06:33:31Z http://ir.unimas.my/id/eprint/26259/ Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy Chai, Chee-Shee Poh, Mau Ern Liam, Chong Kin Mun, Kein Seong Wong, Chee Kuan Tan, Jiunn Liang Loh, Thian Chee Chin, Ka Kiat RC0254 Neoplasms. Tumors. Oncology (including Cancer) Adjuvant chemotherapy has long been indicated to extend survival in completely resected stage IB to IIIA non-small cell lung cancer (NSCLC). However, there is accumulating evidence that chemotherapy or chemoradiotherapy can induce epithelial-to-mesenchymal transition (EMT) in disseminated or circulating NSCLC cells. Here, we describe the first case of EMT as the cause of recurrence and metastasis in a patient with resected stage IIB lung adenosquamous carcinoma after adjuvant chemotherapy. We review the literature and explore the possible mechanisms by which EMT occurs in disseminated tumor cells (DTC) or circulating tumor cells (CTC) in response to adjuvant chemotherapy (cisplatin) as a stressor. We also explore the possible therapeutic strategies to reverse EMT in patients with recurrence. In summary, although adjuvant cisplatin-based chemotherapy in resected NSCLC does extend survival, it may lead to the adverse phenomenon of EMT in disseminated tumor cells (DTC) or circulating tumor cells (CTC) causing recurrence and metastasis. China Lung Oncology Group and John Wiley & Sons Australia, Ltd 2019-07-13 E-Article PeerReviewed text en http://ir.unimas.my/id/eprint/26259/1/Epithelial-to-mesenchymal%20transition%20%28EMT%29%20to%20sarcoma%20in%20recurrent%20lung%20adenosquamous%20-%20Copy.pdf Chai, Chee-Shee and Poh, Mau Ern and Liam, Chong Kin and Mun, Kein Seong and Wong, Chee Kuan and Tan, Jiunn Liang and Loh, Thian Chee and Chin, Ka Kiat (2019) Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy. Thoracic Cancer. pp. 1-5. ISSN 1759-7714 https://onlinelibrary.wiley.com/doi/full/10.1111/1759-7714.13156 DOI: 10.1111/1759-7714.13156
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Chai, Chee-Shee
Poh, Mau Ern
Liam, Chong Kin
Mun, Kein Seong
Wong, Chee Kuan
Tan, Jiunn Liang
Loh, Thian Chee
Chin, Ka Kiat
Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy
description Adjuvant chemotherapy has long been indicated to extend survival in completely resected stage IB to IIIA non-small cell lung cancer (NSCLC). However, there is accumulating evidence that chemotherapy or chemoradiotherapy can induce epithelial-to-mesenchymal transition (EMT) in disseminated or circulating NSCLC cells. Here, we describe the first case of EMT as the cause of recurrence and metastasis in a patient with resected stage IIB lung adenosquamous carcinoma after adjuvant chemotherapy. We review the literature and explore the possible mechanisms by which EMT occurs in disseminated tumor cells (DTC) or circulating tumor cells (CTC) in response to adjuvant chemotherapy (cisplatin) as a stressor. We also explore the possible therapeutic strategies to reverse EMT in patients with recurrence. In summary, although adjuvant cisplatin-based chemotherapy in resected NSCLC does extend survival, it may lead to the adverse phenomenon of EMT in disseminated tumor cells (DTC) or circulating tumor cells (CTC) causing recurrence and metastasis.
format E-Article
author Chai, Chee-Shee
Poh, Mau Ern
Liam, Chong Kin
Mun, Kein Seong
Wong, Chee Kuan
Tan, Jiunn Liang
Loh, Thian Chee
Chin, Ka Kiat
author_facet Chai, Chee-Shee
Poh, Mau Ern
Liam, Chong Kin
Mun, Kein Seong
Wong, Chee Kuan
Tan, Jiunn Liang
Loh, Thian Chee
Chin, Ka Kiat
author_sort Chai, Chee-Shee
title Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy
title_short Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy
title_full Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy
title_fullStr Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy
title_full_unstemmed Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy
title_sort epithelial-to-mesenchymal transition (emt) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy
publisher China Lung Oncology Group and John Wiley & Sons Australia, Ltd
publishDate 2019
url http://ir.unimas.my/id/eprint/26259/1/Epithelial-to-mesenchymal%20transition%20%28EMT%29%20to%20sarcoma%20in%20recurrent%20lung%20adenosquamous%20-%20Copy.pdf
http://ir.unimas.my/id/eprint/26259/
https://onlinelibrary.wiley.com/doi/full/10.1111/1759-7714.13156
_version_ 1671343275073601536
score 13.211869

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