XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians
AIM: To investigate the risk association of xeroderma pigmentosum group C (XPC) Lys939Gln polymorphism alone and in combination with cigarette smoking on colorectal cancer (CRC) predisposition. METHODS: Peripheral blood samples of 510 study subjects (255 CRC patients, 255 controls)were collecte...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Baishideng
2013
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/25572/1/Abdul%20Aziz.pdf http://ir.unimas.my/id/eprint/25572/ https://europepmc.org/abstract/med/23801864 |
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| Summary: | AIM: To investigate the risk association of xeroderma
pigmentosum group C (XPC) Lys939Gln polymorphism
alone and in combination with cigarette smoking on
colorectal cancer (CRC) predisposition.
METHODS: Peripheral blood samples of 510 study
subjects (255 CRC patients, 255 controls)were collected. DNA was extracted and genotyping was performed
using polymerase chain reaction-restriction fragment
length polymorphism. The association between polymorphic genotype and CRC predisposition was determined using the OR and 95%CI.
RESULTS: The frequency of the homozygous variant
(Gln/Gln) genotype was significantly higher in cases
compared with controls (16.0% vs 10.2%, P = 0.049).
The Gln/Gln genotype of XPC showed a significantly
higher association with the risk of CRC (OR = 1.884;
95%CI: 1.082-3.277; P = 0.025). In the case of allele
frequencies, variant allele C was associated with a significantly increased risk of CRC (OR = 1.375; 95%CI:
1.050-1.802; P = 0.020). Moreover, the risk was markedly higher for those who were carriers of the Gln/Gln
variant genotype and were also cigarette smokers (OR
= 3.409; 95%CI: 1.061-10.949; P = 0.032).
CONCLUSION: The XPC Gln/Gln genotype alone and
in combination with smoking increases the risk of CRC
among Malaysians. |
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