Cover Image

Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance

Chloroquine (CQ) resistant P. falciparum was first reported in the 1960s at the Thai-Cambodia border. Gradually CQ resistance has spread and is found in all regions where P. falciparum transmission occurs. The emergence of CQ resistance due to excessive CQ selection pressure on the parasite populati...

Full description

Saved in:
Bibliographic Details
Main Author: Lau, Hui Chong
Format: Thesis
Language:English
Published: Universiti Malaysia Sarawak, (UNIMAS) 2008
Subjects:
R Medicine (General)
RB Pathology
Online Access:http://ir.unimas.my/id/eprint/23/8/Molecular%20characterisation%20of%20the%20plasmodium%20falciparum%20pfcrt%20gene%20involved%20in%20chloroquine%20resistance.pdf
http://ir.unimas.my/id/eprint/23/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.unimas.ir.23
record_format eprints
spelling my.unimas.ir.232023-03-07T07:30:30Z http://ir.unimas.my/id/eprint/23/ Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance Lau, Hui Chong R Medicine (General) RB Pathology Chloroquine (CQ) resistant P. falciparum was first reported in the 1960s at the Thai-Cambodia border. Gradually CQ resistance has spread and is found in all regions where P. falciparum transmission occurs. The emergence of CQ resistance due to excessive CQ selection pressure on the parasite populations has become an important issue because of the higher mortality and morbidity associated with drug resistance. Currently CQ is no longer recommended to treat falciparum malaria. CQ resistance in P. falciparum has been attributed to a single amino acid substitution on the P. falciparum chloroquine resistant transporter (pfcrt) at position 76 where Iysine is substituted with threonine (K76T). Molecular studies showed that CQ resistance emerged independently at five different geographical locations namely: Southeast Asia, two sites in South America, Papua New Guinea and the Philippines. Further analysis of resistant isolates revealed 22 additional non-silent amino acid substitutions on the pfcrt gene with a new amino acid substitution detected in the study reported here. Universiti Malaysia Sarawak, (UNIMAS) 2008 Thesis NonPeerReviewed text en http://ir.unimas.my/id/eprint/23/8/Molecular%20characterisation%20of%20the%20plasmodium%20falciparum%20pfcrt%20gene%20involved%20in%20chloroquine%20resistance.pdf Lau, Hui Chong (2008) Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance. Masters thesis, Universiti Malaysia Sarawak.
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic R Medicine (General)
RB Pathology
spellingShingle R Medicine (General)
RB Pathology
Lau, Hui Chong
Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
description Chloroquine (CQ) resistant P. falciparum was first reported in the 1960s at the Thai-Cambodia border. Gradually CQ resistance has spread and is found in all regions where P. falciparum transmission occurs. The emergence of CQ resistance due to excessive CQ selection pressure on the parasite populations has become an important issue because of the higher mortality and morbidity associated with drug resistance. Currently CQ is no longer recommended to treat falciparum malaria. CQ resistance in P. falciparum has been attributed to a single amino acid substitution on the P. falciparum chloroquine resistant transporter (pfcrt) at position 76 where Iysine is substituted with threonine (K76T). Molecular studies showed that CQ resistance emerged independently at five different geographical locations namely: Southeast Asia, two sites in South America, Papua New Guinea and the Philippines. Further analysis of resistant isolates revealed 22 additional non-silent amino acid substitutions on the pfcrt gene with a new amino acid substitution detected in the study reported here.
format Thesis
author Lau, Hui Chong
author_facet Lau, Hui Chong
author_sort Lau, Hui Chong
title Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_short Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_full Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_fullStr Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_full_unstemmed Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_sort molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
publisher Universiti Malaysia Sarawak, (UNIMAS)
publishDate 2008
url http://ir.unimas.my/id/eprint/23/8/Molecular%20characterisation%20of%20the%20plasmodium%20falciparum%20pfcrt%20gene%20involved%20in%20chloroquine%20resistance.pdf
http://ir.unimas.my/id/eprint/23/
_version_ 1759693338989035520
score 13.211869

Similar Items