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Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease Based On Clinical Phenotypes

Background and Aims: Spanish chronic obstructive pulmonary disease (COPD) guideline classifies COPD into 4 clinical phenotypes: nonexacerbator (A), asthma-COPD overlap (B), exacerbator with emphysema(C) and exacerbator with bronchitis (D). Methods: A cross-sectional study of quality of life (QOL)...

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Main Authors: Ng, Diana Leh-Ching, Liam, Chong Kin, Pang, Yong Kek, Chai, Chee Shee, Poh, Mau Ern, Wong, Chee Kuan, Tan, Jiunn Liang
Format: E-Article
Language:English
Published: Wiley Online Library 2018
Subjects:
R Medicine (General)
Online Access:http://ir.unimas.my/id/eprint/22835/1/Respirology%20QOL.pdf
http://ir.unimas.my/id/eprint/22835/
https://onlinelibrary.wiley.com/doi/10.1111/resp.13420_108
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spelling my.unimas.ir.228352019-07-09T06:58:06Z http://ir.unimas.my/id/eprint/22835/ Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease Based On Clinical Phenotypes Ng, Diana Leh-Ching Liam, Chong Kin Pang, Yong Kek Chai, Chee Shee Poh, Mau Ern Wong, Chee Kuan Tan, Jiunn Liang R Medicine (General) Background and Aims: Spanish chronic obstructive pulmonary disease (COPD) guideline classifies COPD into 4 clinical phenotypes: nonexacerbator (A), asthma-COPD overlap (B), exacerbator with emphysema(C) and exacerbator with bronchitis (D). Methods: A cross-sectional study of quality of life (QOL) based on COPD phenotypes utilizing St George’s Respiratory Questionnaire (SGRQ-c) conducted in University Malaya Medical Center from 1 June 2017 – 31 May 2018. Results: Of 220 patients, 189 patients with post bronchodilator force expiratory volume in 1 second (FEV1)/force vital capacity (FVC) of <0.70 were recruited. Their demographic, clinical characteristics and SGRQ-c score are as shown in Table 1. Patients with phenotype C and D had poorer modified medical research center (MMRC) performance status and global initiative for COPD (GOLD) class based on FEV1. Nevertheless, only patients with phenotype D had significant higher total SGRQ-c score than others. They also scored significant higher in sub-components of COPD symptoms, activities and impacts. Patients with phenotypes B had numerically higher SGRQ-c total and symptoms score than those with phenotype A and C. The total and sub-components SGRQ-c score of patients with phenotype A and C were almost similar. Conclusion: Patients with phenotype D had poorest QOL, followed by phenotype B. These groups of patients need additional medical attention, in terms of pharmacology treatment, physiotherapy and rehabilitation. Wiley Online Library 2018 E-Article PeerReviewed text en http://ir.unimas.my/id/eprint/22835/1/Respirology%20QOL.pdf Ng, Diana Leh-Ching and Liam, Chong Kin and Pang, Yong Kek and Chai, Chee Shee and Poh, Mau Ern and Wong, Chee Kuan and Tan, Jiunn Liang (2018) Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease Based On Clinical Phenotypes. Respirology, 23 (S2). p. 129. ISSN 1440-1843 https://onlinelibrary.wiley.com/doi/10.1111/resp.13420_108 DOI:org/10.1111/resp.13420_108
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Ng, Diana Leh-Ching
Liam, Chong Kin
Pang, Yong Kek
Chai, Chee Shee
Poh, Mau Ern
Wong, Chee Kuan
Tan, Jiunn Liang
Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease Based On Clinical Phenotypes
description Background and Aims: Spanish chronic obstructive pulmonary disease (COPD) guideline classifies COPD into 4 clinical phenotypes: nonexacerbator (A), asthma-COPD overlap (B), exacerbator with emphysema(C) and exacerbator with bronchitis (D). Methods: A cross-sectional study of quality of life (QOL) based on COPD phenotypes utilizing St George’s Respiratory Questionnaire (SGRQ-c) conducted in University Malaya Medical Center from 1 June 2017 – 31 May 2018. Results: Of 220 patients, 189 patients with post bronchodilator force expiratory volume in 1 second (FEV1)/force vital capacity (FVC) of <0.70 were recruited. Their demographic, clinical characteristics and SGRQ-c score are as shown in Table 1. Patients with phenotype C and D had poorer modified medical research center (MMRC) performance status and global initiative for COPD (GOLD) class based on FEV1. Nevertheless, only patients with phenotype D had significant higher total SGRQ-c score than others. They also scored significant higher in sub-components of COPD symptoms, activities and impacts. Patients with phenotypes B had numerically higher SGRQ-c total and symptoms score than those with phenotype A and C. The total and sub-components SGRQ-c score of patients with phenotype A and C were almost similar. Conclusion: Patients with phenotype D had poorest QOL, followed by phenotype B. These groups of patients need additional medical attention, in terms of pharmacology treatment, physiotherapy and rehabilitation.
format E-Article
author Ng, Diana Leh-Ching
Liam, Chong Kin
Pang, Yong Kek
Chai, Chee Shee
Poh, Mau Ern
Wong, Chee Kuan
Tan, Jiunn Liang
author_facet Ng, Diana Leh-Ching
Liam, Chong Kin
Pang, Yong Kek
Chai, Chee Shee
Poh, Mau Ern
Wong, Chee Kuan
Tan, Jiunn Liang
author_sort Ng, Diana Leh-Ching
title Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease Based On Clinical Phenotypes
title_short Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease Based On Clinical Phenotypes
title_full Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease Based On Clinical Phenotypes
title_fullStr Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease Based On Clinical Phenotypes
title_full_unstemmed Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease Based On Clinical Phenotypes
title_sort quality of life of patients with chronic obstructive pulmonary disease based on clinical phenotypes
publisher Wiley Online Library
publishDate 2018
url http://ir.unimas.my/id/eprint/22835/1/Respirology%20QOL.pdf
http://ir.unimas.my/id/eprint/22835/
https://onlinelibrary.wiley.com/doi/10.1111/resp.13420_108
_version_ 1644513882838925312
score 13.211869

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