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Digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (TNF) receptor-associated factor (TRAF) genes

TRAFs are the cytoplasmic adapter proteins that interact with the Tumour Necrosis Factor Receptor (TNFR) family. In human and mammals, there are seven members (TRAF1 - 7) in the TRAFs family. These members share a common TRAF domain at the Carboxyl terminus (C-terminus) and zinc fingers at the amino...

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Main Author: Toh, Wooi Sheng.
Format: Final Year Project Report
Language:English
Published: unimas 2010
Subjects:
Q Science (General)
QH301 Biology
Online Access:http://ir.unimas.my/id/eprint/21178/4/Wooi%28fulltext%29.pdf
http://ir.unimas.my/id/eprint/21178/
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spelling my.unimas.ir.211782024-08-26T08:26:16Z http://ir.unimas.my/id/eprint/21178/ Digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (TNF) receptor-associated factor (TRAF) genes Toh, Wooi Sheng. Q Science (General) QH301 Biology TRAFs are the cytoplasmic adapter proteins that interact with the Tumour Necrosis Factor Receptor (TNFR) family. In human and mammals, there are seven members (TRAF1 - 7) in the TRAFs family. These members share a common TRAF domain at the Carboxyl terminus (C-terminus) and zinc fingers at the amino terminus (N- terminus) with the exception of TRAFI that does not share the ring and zinc fingers, and TRAF7 that does not share the TRAF domain. Previous studies showed that TRAFs regulate the signaling or pathways which were closely related to the apoptosis process. Thus, these processes promote the survival of cancer cell and are linked to cancer development. In order to understand the function of TRAFs in cancer development and between TRAFs family member, three dimensional proteins (3D) models were constructed and used to simulate the interaction of TRAFs protein with other adapter protein in the pathway. The construction of TRAFs models were based on homology modeling, threading modeling and ah initio modeling methods using ModWeb, SWISS-MODEL and I-TASSER severs. There were total 77 models constructed for 7 TRAFs member from the 3 server; 18 from ModWeb, 24 from SWISS- MODFL. and 35 from I-TASSER. These models were then evaluated with ProSa-web, PROVE and PROCI-IECK tools. The full length models were used to perform docking simulation with ASK-1 and TRADD proteins. unimas 2010 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/21178/4/Wooi%28fulltext%29.pdf Toh, Wooi Sheng. (2010) Digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (TNF) receptor-associated factor (TRAF) genes. [Final Year Project Report] (Unpublished)
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
QH301 Biology
spellingShingle Q Science (General)
QH301 Biology
Toh, Wooi Sheng.
Digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (TNF) receptor-associated factor (TRAF) genes
description TRAFs are the cytoplasmic adapter proteins that interact with the Tumour Necrosis Factor Receptor (TNFR) family. In human and mammals, there are seven members (TRAF1 - 7) in the TRAFs family. These members share a common TRAF domain at the Carboxyl terminus (C-terminus) and zinc fingers at the amino terminus (N- terminus) with the exception of TRAFI that does not share the ring and zinc fingers, and TRAF7 that does not share the TRAF domain. Previous studies showed that TRAFs regulate the signaling or pathways which were closely related to the apoptosis process. Thus, these processes promote the survival of cancer cell and are linked to cancer development. In order to understand the function of TRAFs in cancer development and between TRAFs family member, three dimensional proteins (3D) models were constructed and used to simulate the interaction of TRAFs protein with other adapter protein in the pathway. The construction of TRAFs models were based on homology modeling, threading modeling and ah initio modeling methods using ModWeb, SWISS-MODEL and I-TASSER severs. There were total 77 models constructed for 7 TRAFs member from the 3 server; 18 from ModWeb, 24 from SWISS- MODFL. and 35 from I-TASSER. These models were then evaluated with ProSa-web, PROVE and PROCI-IECK tools. The full length models were used to perform docking simulation with ASK-1 and TRADD proteins.
format Final Year Project Report
author Toh, Wooi Sheng.
author_facet Toh, Wooi Sheng.
author_sort Toh, Wooi Sheng.
title Digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (TNF) receptor-associated factor (TRAF) genes
title_short Digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (TNF) receptor-associated factor (TRAF) genes
title_full Digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (TNF) receptor-associated factor (TRAF) genes
title_fullStr Digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (TNF) receptor-associated factor (TRAF) genes
title_full_unstemmed Digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (TNF) receptor-associated factor (TRAF) genes
title_sort digital construction and comparison of hypotetical three dimensional protein models of human tumour necrosis factor (tnf) receptor-associated factor (traf) genes
publisher unimas
publishDate 2010
url http://ir.unimas.my/id/eprint/21178/4/Wooi%28fulltext%29.pdf
http://ir.unimas.my/id/eprint/21178/
_version_ 1808981465380159488
score 13.244414

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