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Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus

An in vitro study was carried out to investigate the antiviral activity in SWA13 and SWB6 fractions of Cymbopogon nardus (L.) Rendle and the synergistic effects from combination of the fractions with ribavirin towards measles virus. The antiviral activity was conducted by treating Vero/SLAM cells wi...

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Main Author: Adibah, binti Ahamad Bahtiar.
Format: Final Year Project Report
Language:English
English
Published: unimas 2008
Subjects:
Q Science (General)
QR Microbiology
Online Access:http://ir.unimas.my/id/eprint/20800/1/Synergistic%20effect%20of%20vibavirin%2024pgs.pdf
http://ir.unimas.my/id/eprint/20800/8/Synergistic%20effect%20of%20ribavirin%20fulltext.pdf
http://ir.unimas.my/id/eprint/20800/
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spelling my.unimas.ir.208002023-01-20T02:49:23Z http://ir.unimas.my/id/eprint/20800/ Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus Adibah, binti Ahamad Bahtiar. Q Science (General) QR Microbiology An in vitro study was carried out to investigate the antiviral activity in SWA13 and SWB6 fractions of Cymbopogon nardus (L.) Rendle and the synergistic effects from combination of the fractions with ribavirin towards measles virus. The antiviral activity was conducted by treating Vero/SLAM cells with two concentrations for C. nardus (0.1 LC50 and 0.5 LC50) and ribavirin (0.01CC50 and 0.005CC50). Two protocols were used in this study. Protocol I [(S+V)+A] was done by inoculating the virus (V) to the cells (S) before being treated with antiviral compounds (A). Protocol II [(S+A)+V], involved inoculation of the cells with virus after treatment with antiviral compounds. The antiviral activity was based on comparison of percentage of cells viability in viral inoculated cells with the control. Data was analyzed using one-way ANOVA and significant data was analyzed with Tukey’s Test. Results of monotherapy showed moderate antiviral activity of SWA13 in Protocol I but low activity in Protocol II. SWB6 exerted low antiviral activity in both protocols. Synergistic effect was observed from combination treatment of 0.005 CC50 RBV + 0.1 LC50 SWB6 in Protocol II with 80.23% cells viability. Further evaluation should be done to identify the active compounds and mechanisms of action of C. nardus extracts unimas 2008 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/20800/1/Synergistic%20effect%20of%20vibavirin%2024pgs.pdf text en http://ir.unimas.my/id/eprint/20800/8/Synergistic%20effect%20of%20ribavirin%20fulltext.pdf Adibah, binti Ahamad Bahtiar. (2008) Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus. [Final Year Project Report] (Unpublished)
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
English
topic Q Science (General)
QR Microbiology
spellingShingle Q Science (General)
QR Microbiology
Adibah, binti Ahamad Bahtiar.
Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus
description An in vitro study was carried out to investigate the antiviral activity in SWA13 and SWB6 fractions of Cymbopogon nardus (L.) Rendle and the synergistic effects from combination of the fractions with ribavirin towards measles virus. The antiviral activity was conducted by treating Vero/SLAM cells with two concentrations for C. nardus (0.1 LC50 and 0.5 LC50) and ribavirin (0.01CC50 and 0.005CC50). Two protocols were used in this study. Protocol I [(S+V)+A] was done by inoculating the virus (V) to the cells (S) before being treated with antiviral compounds (A). Protocol II [(S+A)+V], involved inoculation of the cells with virus after treatment with antiviral compounds. The antiviral activity was based on comparison of percentage of cells viability in viral inoculated cells with the control. Data was analyzed using one-way ANOVA and significant data was analyzed with Tukey’s Test. Results of monotherapy showed moderate antiviral activity of SWA13 in Protocol I but low activity in Protocol II. SWB6 exerted low antiviral activity in both protocols. Synergistic effect was observed from combination treatment of 0.005 CC50 RBV + 0.1 LC50 SWB6 in Protocol II with 80.23% cells viability. Further evaluation should be done to identify the active compounds and mechanisms of action of C. nardus extracts
format Final Year Project Report
author Adibah, binti Ahamad Bahtiar.
author_facet Adibah, binti Ahamad Bahtiar.
author_sort Adibah, binti Ahamad Bahtiar.
title Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus
title_short Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus
title_full Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus
title_fullStr Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus
title_full_unstemmed Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus
title_sort synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (l.) rendle) fractions swa13 and swb6 towards measles virus
publisher unimas
publishDate 2008
url http://ir.unimas.my/id/eprint/20800/1/Synergistic%20effect%20of%20vibavirin%2024pgs.pdf
http://ir.unimas.my/id/eprint/20800/8/Synergistic%20effect%20of%20ribavirin%20fulltext.pdf
http://ir.unimas.my/id/eprint/20800/
_version_ 1755876565439217664
score 13.211869

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