Cover Image

Bisphenol A exposure disturbs the bone metabolism : An evolving interest towards an old culprit

Bisphenol A (BPA) (2,2,-bis (hydroxyphenyl) propane), a well-known endocrine disruptor (ED), is the exogenous chemical that mimic the natural endogenous hormone like oestrogen. Due to its extensive exposure to humans, BPA is considered to be a major toxicological agent for general population. Enviro...

Full description

Saved in:
Bibliographic Details
Main Authors: Thent, Zar Chi, Froemming, Gabriele R.A., Muid, Suhaila
Format: Article
Language:English
Published: Elsevier Inc. 2018
Subjects:
R Medicine (General)
Online Access:http://ir.unimas.my/id/eprint/19848/1/Bisphenol-A-exposure-disturbs-the-bone-metabolism-An-evolving-interest-towards-an-old-culprit_2018_Life-Sciences.html
http://ir.unimas.my/id/eprint/19848/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042041665&doi=10.1016%2fj.lfs.2018.02.013&partnerID=40&md5=90ae252e2db1aa8e811dee7f85c5cf24
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.unimas.ir.19848
record_format eprints
spelling my.unimas.ir.198482021-05-29T13:15:46Z http://ir.unimas.my/id/eprint/19848/ Bisphenol A exposure disturbs the bone metabolism : An evolving interest towards an old culprit Thent, Zar Chi Froemming, Gabriele R.A. Muid, Suhaila R Medicine (General) Bisphenol A (BPA) (2,2,-bis (hydroxyphenyl) propane), a well-known endocrine disruptor (ED), is the exogenous chemical that mimic the natural endogenous hormone like oestrogen. Due to its extensive exposure to humans, BPA is considered to be a major toxicological agent for general population. Environmental exposure of BPA results in adverse health outcomes including bone loss. BPA disturbs the bone health by decreasing the plasma calcium level and inhibiting the calcitonin secretion. BPA also stimulated differentiation and induced apoptosis in human osteoblasts and osteoclasts. However, little is known about the underlying mechanisms of the untoward effect of BPA against bone metabolism. The present review gives an overview on the possible mechanisms of BPA towards bone loss. The previous literature shows that BPA exerts its toxic effect on bone cells by binding to the oestrogen related receptor-gamma (ERγ), reducing the bone morphogenic protein-2 (BMP-2) and alkaline phosphatase (ALP) activities. BPA interrupts the bone metabolism via RANKL, apoptosis and Wnt/β-catenin signaling pathways. It is, however, still debated on the exact underlying mechanism of BPA against bone health. We summarised the molecular evidences with possible mechanisms of BPA, an old environmental culprit, in bone loss and enlightened the underlying understanding of adverse action of BPA in the society. © 2018 Elsevier Inc. Elsevier Inc. 2018-04-01 Article PeerReviewed text en http://ir.unimas.my/id/eprint/19848/1/Bisphenol-A-exposure-disturbs-the-bone-metabolism-An-evolving-interest-towards-an-old-culprit_2018_Life-Sciences.html Thent, Zar Chi and Froemming, Gabriele R.A. and Muid, Suhaila (2018) Bisphenol A exposure disturbs the bone metabolism : An evolving interest towards an old culprit. Life Sciences, 198. pp. 1-7. ISSN 00243205 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042041665&doi=10.1016%2fj.lfs.2018.02.013&partnerID=40&md5=90ae252e2db1aa8e811dee7f85c5cf24 DOI: 10.1016/j.lfs.2018.02.013
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Thent, Zar Chi
Froemming, Gabriele R.A.
Muid, Suhaila
Bisphenol A exposure disturbs the bone metabolism : An evolving interest towards an old culprit
description Bisphenol A (BPA) (2,2,-bis (hydroxyphenyl) propane), a well-known endocrine disruptor (ED), is the exogenous chemical that mimic the natural endogenous hormone like oestrogen. Due to its extensive exposure to humans, BPA is considered to be a major toxicological agent for general population. Environmental exposure of BPA results in adverse health outcomes including bone loss. BPA disturbs the bone health by decreasing the plasma calcium level and inhibiting the calcitonin secretion. BPA also stimulated differentiation and induced apoptosis in human osteoblasts and osteoclasts. However, little is known about the underlying mechanisms of the untoward effect of BPA against bone metabolism. The present review gives an overview on the possible mechanisms of BPA towards bone loss. The previous literature shows that BPA exerts its toxic effect on bone cells by binding to the oestrogen related receptor-gamma (ERγ), reducing the bone morphogenic protein-2 (BMP-2) and alkaline phosphatase (ALP) activities. BPA interrupts the bone metabolism via RANKL, apoptosis and Wnt/β-catenin signaling pathways. It is, however, still debated on the exact underlying mechanism of BPA against bone health. We summarised the molecular evidences with possible mechanisms of BPA, an old environmental culprit, in bone loss and enlightened the underlying understanding of adverse action of BPA in the society. © 2018 Elsevier Inc.
format Article
author Thent, Zar Chi
Froemming, Gabriele R.A.
Muid, Suhaila
author_facet Thent, Zar Chi
Froemming, Gabriele R.A.
Muid, Suhaila
author_sort Thent, Zar Chi
title Bisphenol A exposure disturbs the bone metabolism : An evolving interest towards an old culprit
title_short Bisphenol A exposure disturbs the bone metabolism : An evolving interest towards an old culprit
title_full Bisphenol A exposure disturbs the bone metabolism : An evolving interest towards an old culprit
title_fullStr Bisphenol A exposure disturbs the bone metabolism : An evolving interest towards an old culprit
title_full_unstemmed Bisphenol A exposure disturbs the bone metabolism : An evolving interest towards an old culprit
title_sort bisphenol a exposure disturbs the bone metabolism : an evolving interest towards an old culprit
publisher Elsevier Inc.
publishDate 2018
url http://ir.unimas.my/id/eprint/19848/1/Bisphenol-A-exposure-disturbs-the-bone-metabolism-An-evolving-interest-towards-an-old-culprit_2018_Life-Sciences.html
http://ir.unimas.my/id/eprint/19848/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042041665&doi=10.1016%2fj.lfs.2018.02.013&partnerID=40&md5=90ae252e2db1aa8e811dee7f85c5cf24
_version_ 1701166553607700480
score 13.211869

Similar Items