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Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome

Background: Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD). Materials and methods:...

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Main Authors: W.N, Tiong, Edmund, Ui Hang Sim, Alan, Yean Yip Fong
Format: Article
Language:English
Published: Medknow Publications and Media Pvt. Ltd 2013
Subjects:
QD Chemistry
RB Pathology
Online Access:http://ir.unimas.my/id/eprint/16416/1/Early.pdf
http://ir.unimas.my/id/eprint/16416/
https://www.jcdronline.org/
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spelling my.unimas.ir.164162021-06-05T05:25:56Z http://ir.unimas.my/id/eprint/16416/ Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome W.N, Tiong Edmund, Ui Hang Sim Alan, Yean Yip Fong QD Chemistry RB Pathology Background: Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD). Materials and methods: The serum and peripheral blood gene expression levels of C-reactive protein (CRP) and von Willebrand factor (vWF) in multiethnic Malaysian patients (n = 7) admitted with early hospitalization of ACS was evaluated. Nine patients with stable coronary artery disease without previous history of ACS were enrolled as controls. Results: Serum and peripheral blood mRNA levels of CRP and vWF were significantly higher in ACS compared to control groups (P < 0.05). Conclusions: Elevated levels of these markers in ACS may reflect an acute phase response due to endothelial dysfunction. Both CRP and vWF may add to the list of useful markers for early detection of ACS in hospitals of developing countries. Medknow Publications and Media Pvt. Ltd 2013-03 Article PeerReviewed text en http://ir.unimas.my/id/eprint/16416/1/Early.pdf W.N, Tiong and Edmund, Ui Hang Sim and Alan, Yean Yip Fong (2013) Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome. Journal of Cardiovascular Disease Research, 4 (1). pp. 3-6. ISSN 0975-3583 https://www.jcdronline.org/ DOI: 10.1016/j.jcdr.2012.08.004
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic QD Chemistry
RB Pathology
spellingShingle QD Chemistry
RB Pathology
W.N, Tiong
Edmund, Ui Hang Sim
Alan, Yean Yip Fong
Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome
description Background: Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD). Materials and methods: The serum and peripheral blood gene expression levels of C-reactive protein (CRP) and von Willebrand factor (vWF) in multiethnic Malaysian patients (n = 7) admitted with early hospitalization of ACS was evaluated. Nine patients with stable coronary artery disease without previous history of ACS were enrolled as controls. Results: Serum and peripheral blood mRNA levels of CRP and vWF were significantly higher in ACS compared to control groups (P < 0.05). Conclusions: Elevated levels of these markers in ACS may reflect an acute phase response due to endothelial dysfunction. Both CRP and vWF may add to the list of useful markers for early detection of ACS in hospitals of developing countries.
format Article
author W.N, Tiong
Edmund, Ui Hang Sim
Alan, Yean Yip Fong
author_facet W.N, Tiong
Edmund, Ui Hang Sim
Alan, Yean Yip Fong
author_sort W.N, Tiong
title Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome
title_short Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome
title_full Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome
title_fullStr Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome
title_full_unstemmed Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome
title_sort early detection of c-reactive protein and von willebrand factor levels in malaysian patients with acute coronary syndrome
publisher Medknow Publications and Media Pvt. Ltd
publishDate 2013
url http://ir.unimas.my/id/eprint/16416/1/Early.pdf
http://ir.unimas.my/id/eprint/16416/
https://www.jcdronline.org/
_version_ 1702173245933879296
score 13.211869

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