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Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates

P. knowlesi was the first Plasmodium species in which antigenic variation was observed. Variation was due to schizont infected cell agglutination (SICAvar) antigens expressed by the parasite and transported to the exposed surface of the host erythrocyte [1]. PfEMP1 is P. falciparum’s orthologue...

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Main Authors: Farrah, A Fatih, Siner, Angela, Atique M, Ahmed, Lu, Chan Woon, Craig, Alister G, Staines, Henry M, Balbir, Singh, Sanjeev, Krishna, Cox-Singh, J.
Format: E-Article
Language:English
Published: BioMed Central Ltd. 2010
Subjects:
Q Science (General)
Online Access:http://ir.unimas.my/id/eprint/15805/1/Adaptation%20of%20in%20vitro%20cytoadherence%20assay%20%28abstract%29.pdf
http://ir.unimas.my/id/eprint/15805/
https://www.researchgate.net/publication/47546287_Adaptation_of_in_vitro_cytoadherence_assay_to_Plasmodium_knowlesi_field_isolates
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spelling my.unimas.ir.158052017-04-04T03:52:53Z http://ir.unimas.my/id/eprint/15805/ Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates Farrah, A Fatih Siner, Angela Atique M, Ahmed Lu, Chan Woon Craig, Alister G Staines, Henry M Balbir, Singh Sanjeev, Krishna Cox-Singh, J. Q Science (General) P. knowlesi was the first Plasmodium species in which antigenic variation was observed. Variation was due to schizont infected cell agglutination (SICAvar) antigens expressed by the parasite and transported to the exposed surface of the host erythrocyte [1]. PfEMP1 is P. falciparum’s orthologue of P. knowlesi’s SICA proteins [2]. In P. falciparum PfEMP1 is associated with infected erythrocytes binding to receptors such as ICAM-1 expressed on the endothelial cells of the host microvasculature. Here, we use a static protein assay [3] to determine if naturally occurring human P. knowlesi infections can cause erythrocytes to bind to ICAM-1, VCAM-1 and CD36. BioMed Central Ltd. 2010 E-Article PeerReviewed text en http://ir.unimas.my/id/eprint/15805/1/Adaptation%20of%20in%20vitro%20cytoadherence%20assay%20%28abstract%29.pdf Farrah, A Fatih and Siner, Angela and Atique M, Ahmed and Lu, Chan Woon and Craig, Alister G and Staines, Henry M and Balbir, Singh and Sanjeev, Krishna and Cox-Singh, J. (2010) Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates. Malaria Journal, 9 (2). ISSN 14752875 https://www.researchgate.net/publication/47546287_Adaptation_of_in_vitro_cytoadherence_assay_to_Plasmodium_knowlesi_field_isolates DOI: 10.1186/1475-2875-9-S2-O13
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Farrah, A Fatih
Siner, Angela
Atique M, Ahmed
Lu, Chan Woon
Craig, Alister G
Staines, Henry M
Balbir, Singh
Sanjeev, Krishna
Cox-Singh, J.
Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates
description P. knowlesi was the first Plasmodium species in which antigenic variation was observed. Variation was due to schizont infected cell agglutination (SICAvar) antigens expressed by the parasite and transported to the exposed surface of the host erythrocyte [1]. PfEMP1 is P. falciparum’s orthologue of P. knowlesi’s SICA proteins [2]. In P. falciparum PfEMP1 is associated with infected erythrocytes binding to receptors such as ICAM-1 expressed on the endothelial cells of the host microvasculature. Here, we use a static protein assay [3] to determine if naturally occurring human P. knowlesi infections can cause erythrocytes to bind to ICAM-1, VCAM-1 and CD36.
format E-Article
author Farrah, A Fatih
Siner, Angela
Atique M, Ahmed
Lu, Chan Woon
Craig, Alister G
Staines, Henry M
Balbir, Singh
Sanjeev, Krishna
Cox-Singh, J.
author_facet Farrah, A Fatih
Siner, Angela
Atique M, Ahmed
Lu, Chan Woon
Craig, Alister G
Staines, Henry M
Balbir, Singh
Sanjeev, Krishna
Cox-Singh, J.
author_sort Farrah, A Fatih
title Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates
title_short Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates
title_full Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates
title_fullStr Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates
title_full_unstemmed Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates
title_sort adaptation of in vitro cytoadherence assay to plasmodium knowlesi field isolates
publisher BioMed Central Ltd.
publishDate 2010
url http://ir.unimas.my/id/eprint/15805/1/Adaptation%20of%20in%20vitro%20cytoadherence%20assay%20%28abstract%29.pdf
http://ir.unimas.my/id/eprint/15805/
https://www.researchgate.net/publication/47546287_Adaptation_of_in_vitro_cytoadherence_assay_to_Plasmodium_knowlesi_field_isolates
_version_ 1644512234453336064
score 13.211869

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